Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group
Liu, Weiping1; Su, Jia2,3; Jiang, Jing1; Li, Xingyao2,3; Ye, Qingsong1; Zhou, Hongyu2; Chen, Jialin1; Li, Yan2
Corresponding AuthorLi, Y (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China. ; liyanb@mail.kib.ac.cn
2013-08-19
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume3Pages:2464
AbstractTwo mixed-NH3/amine platinum (II) complexes of 3-dichoroacetoxylcyclobutane-1, 1-dicarboxylate have been prepared in the present study and characterized by elemental analysis and IR, HPLC-MS and(1)H, C-13-NMR. The complexes exist in equilibrium between two position isomeric forms and undergo hydrolysis reaction in aqueous solution, releasing the platinum pharmacophores and dichloroacetate which is a small-molecular cell apoptosis inducer. Both complexes were evaluated for in vitro cytotoxic profile in A549, SGC-7901 and SK-OV-3 caner cells as well as in BEAS-2B normal cells. They exhibit markedly cytoxicity toward cancer cells by selectively inducing the apoptosis of cancer cells, whereas leaving normal cells less affected. They have also the ability to overcome the resistance of SK-OV-3 cancer cells to cisplatin. Our findings offer an alternative novel way to develop platinum drugs which can both overcome the drug resistance and selectively target tumor cells.
KeywordCancer-cells Agents Apoptosis Toxicity Drugs
Subject AreaMultidisciplinary Sciences
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000323194900001
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/16701
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Kunming Inst Precious Met, State Key Lab Platinum Grp Met, Kunming 650106, Yunnan, Peoples R China
2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Liu, Weiping,Su, Jia,Jiang, Jing,et al. Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group[J]. SCIENTIFIC REPORTS,2013,3:2464.
APA Liu, Weiping.,Su, Jia.,Jiang, Jing.,Li, Xingyao.,Ye, Qingsong.,...&Li, Yan.(2013).Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group.SCIENTIFIC REPORTS,3,2464.
MLA Liu, Weiping,et al."Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group".SCIENTIFIC REPORTS 3(2013):2464.
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