Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group
Liu, Weiping1; Su, Jia2,3; Jiang, Jing1; Li, Xingyao2,3; Ye, Qingsong1; Zhou, Hongyu2; Chen, Jialin1; Li, Yan2
2013-08-19
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号3页码:2464
摘要Two mixed-NH3/amine platinum (II) complexes of 3-dichoroacetoxylcyclobutane-1, 1-dicarboxylate have been prepared in the present study and characterized by elemental analysis and IR, HPLC-MS and(1)H, C-13-NMR. The complexes exist in equilibrium between two position isomeric forms and undergo hydrolysis reaction in aqueous solution, releasing the platinum pharmacophores and dichloroacetate which is a small-molecular cell apoptosis inducer. Both complexes were evaluated for in vitro cytotoxic profile in A549, SGC-7901 and SK-OV-3 caner cells as well as in BEAS-2B normal cells. They exhibit markedly cytoxicity toward cancer cells by selectively inducing the apoptosis of cancer cells, whereas leaving normal cells less affected. They have also the ability to overcome the resistance of SK-OV-3 cancer cells to cisplatin. Our findings offer an alternative novel way to develop platinum drugs which can both overcome the drug resistance and selectively target tumor cells.
关键词Cancer-cells Agents Apoptosis Toxicity Drugs
资助信息Major State Basic Research Development Program of China [2009CB522300]; National Key R&D Program of China [2012BAE06B08]; 100 Talents Program of the Chinese Academy of Sciences; Natural Science Foundation of China [21161010, 81173076]; Program of Recruited Top Talents of Sciences and Technology of Yunnan Province [2009C1120]
学科领域Multidisciplinary Sciences
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000323194900001
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16701
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Kunming Inst Precious Met, State Key Lab Platinum Grp Met, Kunming 650106, Yunnan, Peoples R China
2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Liu, Weiping,Su, Jia,Jiang, Jing,et al. Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group[J]. SCIENTIFIC REPORTS,2013,3:2464.
APA Liu, Weiping.,Su, Jia.,Jiang, Jing.,Li, Xingyao.,Ye, Qingsong.,...&Li, Yan.(2013).Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group.SCIENTIFIC REPORTS,3,2464.
MLA Liu, Weiping,et al."Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group".SCIENTIFIC REPORTS 3(2013):2464.
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