| Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii | |
Zhan, Rui1,2; Li, Xiao-Nian1; Du, Xue1; Wang, Wei-Guang1; Dong, Ke1; Su, Jia1; Li, Yan1 ; Pu, Jian-Xin1; Sun, Han-Dong1
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| 通讯作者 | Pu, JX (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China. ; pujianxin@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn |
| 2013-07-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 76期号:7页码:1267-1277 |
| 摘要 | Isorosthin A (1), the first 20-nor-enmein-type diterpenoid, and 15 new ent-kauranoids, isorosthins B-P (2-16), along with 22 known analogues were isolated from the aerial parts of Isodon rosthornii. The structures of 1-16 were elucidated by means of spectroscopic analysis. The relative configuration of 2 and the absolute configuration of 3 were determined by single-crystal X-ray diffraction. Cytotoxicity evaluation against five human tumor lines showed inhibitory effects by several of the compounds tested. Furthermore, 12 of the isolates exhibited inhibitory activity against nitric oxide production in LPS-activated RAW264.7 macrophages. |
| 关键词 | Lasiocarpus Hayata Kudo Nf-kappa-b Leukemic-cells Terpenoids Rubescens Differentiation Cytotoxicity Constituents Pharicin |
| 学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000322562900007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16745 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhan, Rui,Li, Xiao-Nian,Du, Xue,et al. Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(7):1267-1277. |
| APA | Zhan, Rui.,Li, Xiao-Nian.,Du, Xue.,Wang, Wei-Guang.,Dong, Ke.,...&Sun, Han-Dong.(2013).Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii.JOURNAL OF NATURAL PRODUCTS,76(7),1267-1277. |
| MLA | Zhan, Rui,et al."Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii".JOURNAL OF NATURAL PRODUCTS 76.7(2013):1267-1277. |
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