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题名: Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii
作者: Zhan, Rui1, 2; Li, Xiao-Nian1; Du, Xue1; Wang, Wei-Guang1; Dong, Ke1; Su, Jia1; null(李艳)1; Pu, Jian-Xin1; null(孙汉董)1
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: LASIOCARPUS HAYATA KUDO ; NF-KAPPA-B ; LEUKEMIC-CELLS ; TERPENOIDS ; RUBESCENS ; DIFFERENTIATION ; CYTOTOXICITY ; CONSTITUENTS ; PHARICIN
英文摘要: Isorosthin A (1), the first 20-nor-enmein-type diterpenoid, and 15 new ent-kauranoids, isorosthins B-P (2-16), along with 22 known analogues were isolated from the aerial parts of Isodon rosthornii. The structures of 1-16 were elucidated by means of spectroscopic analysis. The relative configuration of 2 and the absolute configuration of 3 were determined by single-crystal X-ray diffraction. Cytotoxicity evaluation against five human tumor lines showed inhibitory effects by several of the compounds tested. Furthermore, 12 of the isolates exhibited inhibitory activity against nitric oxide production in LPS-activated RAW264.7 macrophages.
出版日期: 2013-07-01
卷号: 76, 期号:7, 页码:1267-1277
语种: 英语
收录类别: SCI ; IC
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16745
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China

Recommended Citation:
Zhan, Rui; Li, Xiao-Nian; Du, Xue; Wang, Wei-Guang; Dong, Ke; Su, Jia; Li, Yan; Pu, Jian-Xin; Sun, Han-Dong.Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii,JOURNAL OF NATURAL PRODUCTS,2013,76(7):1267-1277
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