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USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2017, 卷号: 131, 期号: 1, 页码: 29-39
作者:  An, Tao;  Gong, Yaxiao;  Li, Xue;  Kong, Lingmei;  Ma, Pengcheng;  Gong, Liang;  Zhu, Huifang;  Yu, Chunlei;  Liu, Jianmei;  Zhou, Hongyu;  Mao, Bingyu;  Li, Yan
浏览  |  Adobe PDF(3138Kb)  |  收藏  |  浏览/下载：792/146  |  提交时间：2017/04/06
Usp7 Inhibitor  Wnt Signaling  Colorectal Cancer  
Discovery of new dual binding TNKS inhibitors of Wnt signaling inhibition by pharmacophore modeling, molecular docking and bioassay 期刊论文
MOLECULAR BIOSYSTEMS, 2017, 卷号: 13, 期号: 2, 页码: 363-370
作者:  Pu, Yinglan;  Zhang, Shuqun;  Chang, Zhe;  Zhang, Yunqin;  Wang, Dong;  Zhang, Li;  Li, Yan;  Zuo, Zhili
浏览  |  Adobe PDF(972Kb)  |  收藏  |  浏览/下载：692/119  |  提交时间：2017/05/19
Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2016, 卷号: 116, 页码: 39-50
作者:  Zhou, Hongyu;  Shang, Chaowei;  Wang, Min;  Shen, Tao;  Kong, Lingmei;  Yu, Chunlei;  Ye, Zhennan;  Luo, Yan;  Liu, Lei;  Li, Yan;  Huang, Shile
浏览  |  Adobe PDF(3794Kb)  |  收藏  |  浏览/下载：181/38  |  提交时间：2017/01/05
Ciclopirox  Mtor  Ampk  Tsc2  Raptor  
Synthesis and antitumor activity of novel N-substituted tetrahydro-beta-carboline-imidazolium salt derivatives 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2016, 卷号: 14, 期号: 39, 页码: 9423-9430
作者:  Zhou, Bei;  Liu, Zheng-Fen;  Deng, Guo-Gang;  Chen, Wen;  Li, Min-Yan;  Yang, Li-Juan;  Li, Yan;  Yang, Xiao-Dong;  Zhang, Hong-Bin
浏览  |  Adobe PDF(5636Kb)  |  收藏  |  浏览/下载：196/38  |  提交时间：2016/12/21
ent-Kauranoids isolated from Isodon eriocalyx var. laxiflora and their structure activity relationship analyses 期刊论文
TETRAHEDRON, 2015, 卷号: 71, 期号: 48, 页码: 9161-9171
作者:  Wang,Wei-Guang;  Yang,Jin;  Wu,Hai-Yan;  Kong,Ling-Mei;  Su,Jia;  Li,Xiao-Nian;  Du,Xue;  Zhan,Rui;  Zhou,Min;  Li,Yan;  Pu,Jian-Xin;  Sun,Han-Dong
浏览  |  Adobe PDF(1109Kb)  |  收藏  |  浏览/下载：231/55  |  提交时间：2016/01/19
Ent-kaurane  Diterpenoids  Isodon  
Synthesis and antitumor activity of novel per-butyrylated glycosides of podophyllotoxin and its derivatives 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 7, 页码: 1437-1446
作者:  Zi, Cheng-Ting;  Yang, Dan;  Dong, Fa-Wu;  Li, Gen-Tao;  Li, Yan;  Ding, Zhong-Tao;  Zhou, Jun;  Jiang, Zi-Hua;  Hu, Jiang-Miao;  Jiang,ZH (reprint author),Yunnan Univ,Key Lab Med Chem Nat Resource,Kunming 650091,Peoples R China.;  zjiang@lakeheadu.ca;  hujiangmiao@mail.kib.ac.cn
浏览  |  Adobe PDF(842Kb)  |  收藏  |  浏览/下载：321/88  |  提交时间：2015/06/29
Podophyllotoxin  Epipodophyllotoxin  4 '-demethylepipodophyllotoxin  Butyrylated Glycosides  Antitumor  Cytotoxic  Synthesis  
Design, Synthesis, and Cytotoxicity of Perbutyrylated Glycosides of 4 beta-Triazolopodophyllotoxin Derivatives 期刊论文
MOLECULES, 2015, 卷号: 20, 期号: 2, 页码: 3255-3280
作者:  Zi, Cheng-Ting;  Liu, Zhen-Hua;  Li, Gen-Tao;  Li, Yan;  Zhou, Jun;  Ding, Zhong-Tao;  Hu, Jiang-Miao;  Jiang, Zi-Hua;  Ding,ZT (reprint author),Yunnan Univ,Key Lab Med Chem Nat Resource,Minist Educ,Sch Chem Sci & Technol,Kunming 650091,Peoples R China.;  zict@sina.cn;  liuzhenhua@mail.kib.ac.cn;  ligentao@mail.kib.ac.cn;  liyanb@mail.kib.ac.cn;  jzhou@mail.kib.ac.cn;  ztding@ynu.edu.cn;  hujiangmiao@mail.kib.ac.cn;  zjiang@lakeheadu.ca
浏览  |  Adobe PDF(910Kb)  |  收藏  |  浏览/下载：265/57  |  提交时间：2015/06/29
Cinchona Alkaloids from Cinchona succirubra and Cinchona ledgeriana 期刊论文
PLANTA MEDICA, 2014, 卷号: 80, 期号: 2-3, 页码: 223-230
作者:  Cheng, Gui-Guang;  Cai, Xiang-Hai;  Zhang, Bao-Hong;  Li, Yan;  Gu, Ji;  Bao, Mei-Fen;  Liu, Ya-Ping;  Luo, Xiao-Dong
Adobe PDF(169Kb)  |  收藏  |  浏览/下载：402/115  |  提交时间：2014/04/09
Multidrug-resistance  Combined Nmr  Leaves  Quinidine  Quinine  Root  Derivatives  Cultures  Moens  Leaf  
Talaflavuterpenoid A, a new nardosinane-type sesquiterpene from Talaromyces flavus 期刊论文
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2014, 卷号: 16, 期号: 10, 页码: 1029-1034
作者:  He, Jun-Wei;  Liang, Hao-Xian;  Gao, Hao;  Kuang, Run-Qiao;  Chen, Guo-Dong;  Hu, Dan;  Wang, Chuan-Xi;  Liu, Xing-Zhong;  Li, Yan;  Yao, Xin-Sheng;  Gao,H (reprint author),Jinan Univ,Inst Tradit Chinese Med & Nat Prod,Coll Pharm,Guangzhou 510632,Guangdong,Peoples R China.;  tghao@jnu.edu.cn;  tyaoxs@jnu.edu.cn
Adobe PDF(208Kb)  |  收藏  |  浏览/下载：361/71  |  提交时间：2014/11/25
Wetland Soil-derived Fungus  Talaromyces Flavus  Nardosinane-type Sesquiterpene  Structure Elucidation  Biological Activities  
Synthesis and Anticancer Activity of Glucosylated Podophyllotoxin Derivatives Linked via 4 beta-Triazole Rings 期刊论文
MOLECULES, 2013, 卷号: 18, 期号: 11, 页码: 13992-14012
作者:  Zi, Cheng-Ting;  Xu, Feng-Qing;  Li, Gen-Tao;  Li, Yan;  Ding, Zhong-Tao;  Zhou, Jun;  Jiang, Zi-Hua;  Hu, Jiang-Miao
浏览  |  Adobe PDF(404Kb)  |  收藏  |  浏览/下载：190/51  |  提交时间：2015/05/13
Podophyllotoxin  4 Beta-triazole Ring  Click Chemistry  Anticancer Activity