ent-Kauranoids isolated from Isodon eriocalyx var. laxiflora and their structure activity relationship analyses

doi:10.1016/j.tet.2015.09.066

	ent-Kauranoids isolated from Isodon eriocalyx var. laxiflora and their structure activity relationship analyses
	Wang,Wei-Guang; Yang,Jin; Wu,Hai-Yan; Kong,Ling-Mei; Su,Jia; Li,Xiao-Nian; Du,Xue; Zhan,Rui; Zhou,Min; Li,Yan; Pu,Jian-Xin; Sun,Han-Dong
	2015-12-02
发表期刊	TETRAHEDRON
卷号	71 期号:48 页码:9161-9171
摘要	In this report, a new cytotoxic group, a 15-oxo-16 alpha-H-17-methoxy (or ethoxy)- unit, was suggested from the structure-activity relationship analyses of 39 ent-kaurane diterpenoids, including 17 new compounds (neolaxiflorins I-Y, 1-17) isolated from the leaves of Isodon eriocalyx var. laxiflora using an in vitro cytotoxicity assay against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 human cancer cell lines. This discovery is counter to the rule that the alpha,beta-unsaturated ketone (C-15-C-16-C-17) unit is indispensable for cytotoxicity of the ent-kauranoids. Furthermore, portions of the isolates exhibited inhibitory activity against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages. The NF-kappa B inhibitory activity assay suggests a potential novel cytotoxic mechanism for compounds 9 and 22. (C) 2015 Elsevier Ltd. All rights reserved.
关键词	Ent-kaurane Diterpenoids Isodon
DOI	10.1016/j.tet.2015.09.066
收录类别	SCI
语种	英语
WOS记录号	WOS:000364885800015
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25243
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Wang,Wei-Guang,Yang,Jin,Wu,Hai-Yan,et al. ent-Kauranoids isolated from Isodon eriocalyx var. laxiflora and their structure activity relationship analyses[J]. TETRAHEDRON,2015,71(48):9161-9171.
APA	Wang,Wei-Guang.,Yang,Jin.,Wu,Hai-Yan.,Kong,Ling-Mei.,Su,Jia.,...&Sun,Han-Dong.(2015).ent-Kauranoids isolated from Isodon eriocalyx var. laxiflora and their structure activity relationship analyses.TETRAHEDRON,71(48),9161-9171.
MLA	Wang,Wei-Guang,et al."ent-Kauranoids isolated from Isodon eriocalyx var. laxiflora and their structure activity relationship analyses".TETRAHEDRON 71.48(2015):9161-9171.

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