| Synthesis and antitumor activity of novel N-substituted tetrahydro-beta-carboline-imidazolium salt derivatives | |
Zhou, Bei1; Liu, Zheng-Fen1; Deng, Guo-Gang1; Chen, Wen1; Li, Min-Yan2; Yang, Li-Juan3; Li, Yan4 ; Yang, Xiao-Dong1; Zhang, Hong-Bin1
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| 2016 | |
| 发表期刊 | ORGANIC & BIOMOLECULAR CHEMISTRY
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| 卷号 | 14期号:39页码:9423-9430 |
| 摘要 | The synthesis of a series of novel N-substituted tetrahydro-beta-carboline-imidazolium salt derivatives is presented. The biological properties of the compounds were evaluated in vitro against a panel of human tumor cell lines. The results suggest that the benzimidazole ring and 1-(naphthalen-2-yl) ethan-1-one or 2-naphthylmethyl substituent at the imidazolyl-3-position were vital for modulating cytotoxic activity. Compound 41 was observed as a potent derivative with IC50 values of 3.24-8.78 mu M and exhibited cytotoxic activity selectively against HL-60, A-549 and MCF-7 cell lines. Meanwhile, high inhibitory activities selectively against HL-60 and MCF-7 cell lines were observed for compound 51. Moreover, compound 51 was able to induce G1 phase cell cycle arrest and apoptosis in MCF-7 cells. The cytotoxicity of compound 51 against human normal lung epithelial cell line BEAS-2B was further evaluated. |
| DOI | 10.1039/c6ob01495j |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000385174800029 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/33534 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China 2.Univ Penn, Dept Chem, Philadelphia, PA 19104 USA 3.Yunnan Minzu Univ, Sch Chem Environm, Kunming 650500, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Bei,Liu, Zheng-Fen,Deng, Guo-Gang,et al. Synthesis and antitumor activity of novel N-substituted tetrahydro-beta-carboline-imidazolium salt derivatives[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2016,14(39):9423-9430. |
| APA | Zhou, Bei.,Liu, Zheng-Fen.,Deng, Guo-Gang.,Chen, Wen.,Li, Min-Yan.,...&Zhang, Hong-Bin.(2016).Synthesis and antitumor activity of novel N-substituted tetrahydro-beta-carboline-imidazolium salt derivatives.ORGANIC & BIOMOLECULAR CHEMISTRY,14(39),9423-9430. |
| MLA | Zhou, Bei,et al."Synthesis and antitumor activity of novel N-substituted tetrahydro-beta-carboline-imidazolium salt derivatives".ORGANIC & BIOMOLECULAR CHEMISTRY 14.39(2016):9423-9430. |
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| c6ob01495j1.pdf（5636KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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