Synthesis and antitumor activity of novel N-substituted tetrahydro-beta-carboline-imidazolium salt derivatives
Zhou, Bei1; Liu, Zheng-Fen1; Deng, Guo-Gang1; Chen, Wen1; Li, Min-Yan2; Yang, Li-Juan3; Li, Yan4; Yang, Xiao-Dong1; Zhang, Hong-Bin1
2016
Source PublicationORGANIC & BIOMOLECULAR CHEMISTRY
Volume14Issue:39Pages:9423-9430
AbstractThe synthesis of a series of novel N-substituted tetrahydro-beta-carboline-imidazolium salt derivatives is presented. The biological properties of the compounds were evaluated in vitro against a panel of human tumor cell lines. The results suggest that the benzimidazole ring and 1-(naphthalen-2-yl) ethan-1-one or 2-naphthylmethyl substituent at the imidazolyl-3-position were vital for modulating cytotoxic activity. Compound 41 was observed as a potent derivative with IC50 values of 3.24-8.78 mu M and exhibited cytotoxic activity selectively against HL-60, A-549 and MCF-7 cell lines. Meanwhile, high inhibitory activities selectively against HL-60 and MCF-7 cell lines were observed for compound 51. Moreover, compound 51 was able to induce G1 phase cell cycle arrest and apoptosis in MCF-7 cells. The cytotoxicity of compound 51 against human normal lung epithelial cell line BEAS-2B was further evaluated.
DOI10.1039/c6ob01495j
Indexed BySCI
Language英语
WOS IDWOS:000385174800029
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/33534
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China
2.Univ Penn, Dept Chem, Philadelphia, PA 19104 USA
3.Yunnan Minzu Univ, Sch Chem Environm, Kunming 650500, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Bei,Liu, Zheng-Fen,Deng, Guo-Gang,et al. Synthesis and antitumor activity of novel N-substituted tetrahydro-beta-carboline-imidazolium salt derivatives[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2016,14(39):9423-9430.
APA Zhou, Bei.,Liu, Zheng-Fen.,Deng, Guo-Gang.,Chen, Wen.,Li, Min-Yan.,...&Zhang, Hong-Bin.(2016).Synthesis and antitumor activity of novel N-substituted tetrahydro-beta-carboline-imidazolium salt derivatives.ORGANIC & BIOMOLECULAR CHEMISTRY,14(39),9423-9430.
MLA Zhou, Bei,et al."Synthesis and antitumor activity of novel N-substituted tetrahydro-beta-carboline-imidazolium salt derivatives".ORGANIC & BIOMOLECULAR CHEMISTRY 14.39(2016):9423-9430.
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