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Discovery and synthesis of rocaglaol derivatives inducing apoptosis in HCT116 cells via suppression of MAPK signaling pathway 期刊论文
FITOTERAPIA, 2021, 卷号: 151, 页码: 104876
作者:  Yang,Hao-Jie;  Li,Ya-Nan;  Yan,Chen;  Yang,Jue;  Zeng,Yan-Rong;  Yi,Ping;  Li,Yan-Mei;  Hao,Xiao-Jiang;  Yuan,Chun-Mao
浏览  |  Adobe PDF(2804Kb)  |  收藏  |  浏览/下载:80/22  |  提交时间:2022/04/02
Dysoxylum gotadhora  Rocaglaol derivatives  HCT116  Cytotoxic activity  MAPK pathway  FLAVAGLINES  
Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells 期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2021, 卷号: 17, 期号: 11, 页码: 2703-2717
作者:  Wei,Ruiran;  Zhao,Yueqin;  Wang,Juan;  Yang,Xu;  Li,Shunlin;  Wang,Yinyuan;  Yang,Xingzhi;  Fei,Jimin;  Hao,Xiaojiang;  Zhao,Yuhan;  Gui,Liming;  Ding,Xiao
浏览  |  Adobe PDF(9123Kb)  |  收藏  |  浏览/下载:90/13  |  提交时间:2022/04/02
Ferroptosis  Tagitinin c  Ros  Er Stress  Nrf2-ho-1 Pathway  Endoplasmic-reticulum Stress  Er-stress  Oxidative Stress  Tumor-suppressor  Nrf2  Death  Iron  Differentiation  Mechanisms  Resistance  
Natural product sciences: an integrative approach to the innovations of plant natural products 期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2020
作者:  Shen, Yuemao;  Hao, Xiaojiang
浏览  |  Adobe PDF(4992Kb)  |  收藏  |  浏览/下载:100/14  |  提交时间:2021/01/05
Acylphloroglucinols with acetylcholinesterase inhibitory effects from the fruits of Eucalyptus robusta 期刊论文
BIOORGANIC CHEMISTRY, 2020
作者:  Liu, Hui;  He, Xiao-Zhi;  Feng, Mi-Yan;  Yuan-Zeng;  Rauwolf, Tyler J.;  Shao, Li-Dong;  Ni, Wei;  Yan, Hui;  Porco, John A., Jr.;  Hao, Xiao-Jiang;  Qin, Xu-Jie;  Liu, Hai-Yang
浏览  |  Adobe PDF(3924Kb)  |  收藏  |  浏览/下载:218/70  |  提交时间:2021/01/05
Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization 期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 7, 页码: 10
作者:  Zhang, Yu;  Goto, Masuo;  Oda, Akifumi;  Hsu, Pei-Ling;  Guo, Ling-Li;  Fu, Yan-Hui;  Morris-Natschke, Susan L.;  Hamel, Ernest;  Lee, Kuo-Hsiung;  Hao, Xiao-Jiang
浏览  |  Adobe PDF(3129Kb)  |  收藏  |  浏览/下载:214/23  |  提交时间:2019/07/29
aspidosperma-type  monoterpenoid indole alkaloids  antiproliferative activity  tubulin inhibitor  Bousigonia mekongensis  
Synthesis of novel guttiferone E and xanthochymol derivatives with cytotoxicities by inducing cell apoptosis and arresting the cell cycle phase 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 162, 页码: 765-780
作者:  Lin, Xin;  Tian, Dongsong;  Fu, Yanhui;  Li, Yanan;  Huang, Liejun;  Gu, Wei;  Song, Jialei;  Li, Yanmei;  Ben-David, Yaacov;  Wen, Min;  Yuan, Chunmao;  Hao, Xiaojiang
浏览  |  Adobe PDF(2607Kb)  |  收藏  |  浏览/下载:282/48  |  提交时间:2019/03/18
Polycyclic polyprenylated acylphloroglucinol  Chemical transformation  Cytotoxicity  Cell apoptosis  Cell cycle arrest  
Efficient synthesis of new phenanthridine Wnt/b-catenin signaling pathway agonists 期刊论文
European Journal of Medicinal Chemistry, 2018, 卷号: 157, 页码: 1491-1499
作者:  Duozhi Chen;  Heng Zhang;  Chenxu Jing;  Xiaoli He;  Bijuan Yang;  Jieyun Cai;  Yunfu Zhou;  Xiaoming Song;  Lin Li;  Xiaojiang Hao
浏览  |  Adobe PDF(1966Kb)  |  收藏  |  浏览/下载:213/81  |  提交时间:2019/03/27
Anti-HIV Activities and Mechanism of 12-O-Tricosanoylphorbol-20-acetate, a Novel Phorbol Ester from Ostodes katharinae 期刊论文
MOLECULES, 2017, 卷号: 22, 期号: 9, 页码: 1498
作者:  Chen, Huan;  Zhang, Rong;  Luo, Rong-Hua;  Yang, Liu-Meng;  Wang, Rui-Rui;  Hao, Xiao-Jiang;  Zheng, Yong-Tang
浏览  |  Adobe PDF(1939Kb)  |  收藏  |  浏览/下载:195/38  |  提交时间:2017/10/23
Antiviral Agent  12-o-tricosanoylphorbol-20-acetate  Hiv  Vif  Apobec3g  Phorbol Ester  
Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/beta-catenin transcriptional activity 期刊论文
CELL DISCOVERY, 2017, 卷号: 3, 页码: 17003
作者:  He, Xiaoli;  Zhang, Wenjuan;  Yan, Chen;  Nie, Fen;  Li, Chen;  Liu, Xiaofen;  Fei, Cong;  Li, Shengdi;  Song, Xiaomin;  Jia, Yingying;  Zeng, Rong;  Wu, Dianqing;  Pan, Weijun;  Hao, Xiaojiang;  Li, Lin
浏览  |  Adobe PDF(3775Kb)  |  收藏  |  浏览/下载:144/37  |  提交时间:2017/12/18
Carf  Chemical Biology  Nc043  Small Molecule  Wnt Signaling  
Cyclohexane-Fused Octahydroquinolizine Alkaloids from Myrioneuron faberi with Activity against Hepatitis C Virus 期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2014, 卷号: 79, 期号: 17, 页码: 7945-7950
作者:  Cao, Ming-Ming;  Zhang, Yu;  Li, Xiao-Hui;  Peng, Zong-Gen;  Jiang, Jian-Dong;  Gu, Yu-Cheng;  Di, Ying-Tong;  Li, Xiao-Nian;  Chen, Duo-Zhi;  Xia, Cheng-Feng;  He, Hong-Ping;  Li, Shun-Lin;  Hao, Xiao-Jiang;  haoxj@mail.kib.ac.cn
Adobe PDF(364Kb)  |  收藏  |  浏览/下载:294/77  |  提交时间:2014/11/25
Biomimetic Synthesis  Nutans  Nitraramine  Skeleton  Therapy