Discovery and synthesis of rocaglaol derivatives inducing apoptosis in HCT116 cells via suppression of MAPK signaling pathway

doi:10.1016/j.fitote.2021.104876

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	Discovery and synthesis of rocaglaol derivatives inducing apoptosis in HCT116 cells via suppression of MAPK signaling pathway
	Yang,Hao-Jie ; Li,Ya-Nan ; Yan,Chen ; Yang,Jue ; Zeng,Yan-Rong ; Yi,Ping ; Li,Yan-Mei ; Hao,Xiao-Jiang; Yuan,Chun-Mao
	2021
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	151 页码:104876
摘要	Six rocaglaol derivatives were isolated from Dysoxylum gotadhora, and those compounds showed good cytotoxic activity with IC50 values ranging from 10 to 350 ng/mL against five different cancer cells. Obviously, further total synthesis of rocaglaol derivatives for medical chemistry study is of great significance. Then, twenty six rocaglaol derivatives including 25 new compounds were designed, synthesized, and evaluated for their cytotoxic activities against three human cancer cell lines: human colon cancer cells (HCT116), colorectal cancer stem cells (P6C), and human red leukocyte leukemia cells (HEL), using MTT assay. Most of derivatives showed good cytotoxic activities, with the lowest IC50 being 3.2 nM for HEL cells, which was 169 times stronger than that of the positive control (doxorubicin). Further mechanism study indicated that 11k could significantly suppress MAPK pathway in HCT116 cells, which may responsible for induction of apoptosis and cell cycle arrest.
关键词	Dysoxylum gotadhora Rocaglaol derivatives HCT116 Cytotoxic activity MAPK pathway FLAVAGLINES
DOI	10.1016/j.fitote.2021.104876
WOS记录号	WOS:000663435300023
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73493
专题	中国科学院昆明植物研究所
作者单位	1.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China 2.Chinese Acad Sci, Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Peoples R China 3.An Shun City Peoples Hosp, Anshun 561000, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Yang,Hao-Jie,Li,Ya-Nan,Yan,Chen,et al. Discovery and synthesis of rocaglaol derivatives inducing apoptosis in HCT116 cells via suppression of MAPK signaling pathway[J]. FITOTERAPIA,2021,151:104876.
APA	Yang,Hao-Jie.,Li,Ya-Nan.,Yan,Chen.,Yang,Jue.,Zeng,Yan-Rong.,...&Yuan,Chun-Mao.(2021).Discovery and synthesis of rocaglaol derivatives inducing apoptosis in HCT116 cells via suppression of MAPK signaling pathway.FITOTERAPIA,151,104876.
MLA	Yang,Hao-Jie,et al."Discovery and synthesis of rocaglaol derivatives inducing apoptosis in HCT116 cells via suppression of MAPK signaling pathway".FITOTERAPIA 151(2021):104876.

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