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High throughput-screening of native herbal compounds identifies taccaoside A as a cytotoxic compound that mediates RAS signaling in cancer stem cells 期刊论文
PHYTOMEDICINE, 2023, 卷号: 108, 页码: 154492
作者:  Yang,Dong;  Dai,Zhi;  Zhu,Peifeng;  Wang,Gan;  Sun,Bin;  Li,Shirong;  Hao,Junjun;  Wang,Yifen;  Liu,Yaping;  Yu,Shuaishuai;  Lai,Ren;  Luo,Xiao-Dong;  Zhao,Xudong
浏览  |  Adobe PDF(6987Kb)  |  收藏  |  浏览/下载：73/11  |  提交时间：2024/07/17
Natural product  Furostanol saponin  Taccaoside A  Cancer stem cell  RAS  STEROIDAL SAPONINS  NATURAL-PRODUCTS  PI3K/AKT  PROLIFERATION  MAINTENANCE  STATISTICS  MAPK/ERK  
Enantioselective Total Synthesis of the Cephalotaxus Alkaloid (-)-Cephalotine A 期刊论文
ORGANIC LETTERS, 2023
作者:  Sheng,Peng-Zhen;  Li,Lu-Lu;  Ni,Zhi-Bin;  Wei,Kun;  Yang,Yu-Rong
浏览  |  Adobe PDF(1433Kb)  |  收藏  |  浏览/下载：33/11  |  提交时间：2024/07/10
FORMAL TOTAL-SYNTHESIS  ALPHA-ALLYLATION  UNIFIED STRATEGY  NATURAL-PRODUCTS  GAMMA-LACTAMS  HECK REACTION  (+/-)-CEPHALOTAXINE  REARRANGEMENT  C  
Identification of New Diterpenoids from the Pulp of Coffea arabica and Their α-Glucosidase Inhibition Activity 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2023, 卷号: 72, 期号: 3, 页码: 1683-1694
作者:  Al-Romaima,Abdulbaset;  Hu,Guilin;  Wang,Yanbing;  Quan,Chenxi;  Dai,Haopeng;  Qiu,Minghua
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Coffeaarabica  coffee pulp  diterpenoids  structure elucidation  alpha-glucosidase  moleculardocking  ENT-KAURANE DITERPENES  ACID  PRODUCTS  EXTRACTS  CAFFEINE  CAFESTOL  ESTERS  BEANS  
Leucosceptrane Sesterterpenoids as a New Type of Natural Immunosuppressive Agents in Treating Sepsis 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 67, 期号: 1, 页码: 513-528
作者:  Guo,Kai;  Zhou,Ting-Ting;  Luo,Shi-Hong;  Liu,Yan-Chun;  Liu,Yan;  Li,Sheng-Hong
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GLANDULAR TRICHOMES  PRODUCTS  HARBOR  CANUM  
Discovery of Natural Potent HMG-CoA Reductase Degraders for Lowering Cholesterol 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023
作者:  Su,Xiao-Zheng;  Zhang,Lin-Fei;  Hu,Kun;  An,Yang;  Zhang,Qiao-Peng;  Tang,Jian-Wei;  Yan,Bing-Chao;  Li,Xing-Ren;  Cai,Jie;  Li,Xiao-Nian;  Sun,Han-Dong;  Jiang,Shi-You;  Puno,Pema-Tenzin
浏览  |  Adobe PDF(7289Kb)  |  收藏  |  浏览/下载：71/12  |  提交时间：2024/07/10
Enzymes  Meroterpenoids  Natural Products  Proteomics  Semisynthesis  STATIN  FUNGUS  RISK  ACID  
A Mushroom P450-Monooxygenase Enables Regioand Stereoselective Biocatalytic Synthesis of Epoxycyclohexenones 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 卷号: 62, 期号: 49
作者:  Yang,Yan-Long;  Zhou,Man;  Yang,Lin;  Gressler,Markus;  Rassbach,Johannes;  Wurlitzer,Jacob M.;  Zeng,Ying;  Gao,Kun;  Hoffmeister,Dirk
浏览  |  Adobe PDF(1998Kb)  |  收藏  |  浏览/下载：48/11  |  提交时间：2024/07/10
Biocatalysis  Biosynthesis  Cytochrome P450  Epoxycyclohexenone  Natural Products  OPPOSITE FACIAL SPECIFICITY  NATURAL-PRODUCTS  STREPTOMYCES LL-C10037  BIOSYNTHESIS  EPOXYQUINONE  CYTOCHROME-P450  FERMENTATION  PANEPOXYDONE  EPOXIDATION  INHIBITION  
Natural product Eriocalyxin B suppressed triple negative breast cancer metastasis both in vitro and in vivo 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2023, 卷号: 210, 页码: 115491
作者:  Gou,Leilei;  Yue,Grace Gar-Lee;  Lee,Julia Kin -Ming;  Puno,Pema Tenzin;  Lau,Clara Bik-San
浏览  |  Adobe PDF(16654Kb)  |  收藏  |  浏览/下载：61/7  |  提交时间：2024/07/22
Breast cancer  Metastasis  Natural products  Eriocalyxin B  Cancer recurrence  Cancer stem cells  Gut microbiome  NF-KAPPA-B  STEM-CELLS  MOLECULAR-MECHANISMS  EXTRACELLULAR-MATRIX  TUMOR-GROWTH  APOPTOSIS  ANGIOGENESIS  PROGRESSION  CARCINOMA  LEUKEMIA  
Structurally diverse spirocyclic polycyclic polyprenylated acylphloroglucinols from Hypericum ascyron Linn. and their anti-tumor activity 期刊论文
PHYTOCHEMISTRY, 2023, 卷号: 212, 页码: 113727
作者:  Hu,Ya-Li;  Yue,Grace Gar-Lee;  Li,Xing-Ren;  Xu,Gang;  Lau,Clara Bik-San
浏览  |  Adobe PDF(6872Kb)  |  收藏  |  浏览/下载：37/13  |  提交时间：2024/07/25
Hypericaceae  Polycyclic polyprenylated acylphloroglucinols  Spirocyclic polyprenylated acylphloroglucinols  HCT116 cells  Zebrafish model  Hypericum ascyron Linn  NATURAL-PRODUCTS  A-H  DERIVATIVES  FLOWERS  VEGF  
Antiviral Isocoumarins from a Cigar Tobacco-Derived Endophytic Fungus Aspergillus oryzae 期刊论文
CHEMISTRY OF NATURAL COMPOUNDS, 2023, 卷号: 59, 期号: 2, 页码: 242-245
作者:  Kong,Guang-Hui;  Gu,Xue-Jiao;  Wu,Jing;  Zheng,Jun-Na;  Huang,De-Quan;  Zhang,Guang-Hai;  Bao,Mei-Fen;  Hu,Qiu-Fen;  Wu,Yu-Ping;  Li,Yin-Ke
浏览  |  Adobe PDF(87Kb)  |  收藏  |  浏览/下载：68/20  |  提交时间：2024/05/09
isocoumarins  endophytic fungus A  oryzae  cigar tobacco  anti-TMV activity  FERMENTATION PRODUCTS  DERIVATIVES  BUTYROLACTONES  
Design, Synthesis, and Evaluation of the COX-2 Inhibitory Activities of New 1,3-Dihydro-2H-indolin-2-one Derivatives 期刊论文
MOLECULES, 2023, 卷号: 28, 期号: 12, 页码: 4668
作者:  Pan,Taohua;  He,Maofei;  Deng,Lulu;  Li,Jiang;  Fan,Yanhua;  Hao,Xiaojiang;  Mu,Shuzhen
浏览  |  Adobe PDF(3057Kb)  |  收藏  |  浏览/下载：68/13  |  提交时间：2024/05/09
oxindoles  alpha,beta-unsaturated ketone  anti-inflammatory  COX-2 inhibitory activity  ANTIINFLAMMATORY ACTIVITY  NATURAL-PRODUCTS  OXINDOLE-DERIVATIVES  NITRIC-OXIDE  POTENT  CYCLOOXYGENASE-2  DISCOVERY  PAIN  LIABILITY