Identification of New Diterpenoids from the Pulp of Coffea arabica and Their α-Glucosidase Inhibition Activity

doi:10.1021/acs.jafc.3c05619

KIB OpenIR

	Identification of New Diterpenoids from the Pulp of Coffea arabica and Their α-Glucosidase Inhibition Activity
	Al-Romaima,Abdulbaset; Hu,Guilin; Wang,Yanbing; Quan,Chenxi; Dai,Haopeng; Qiu,Minghua
	2023
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN	1520-5118
卷号	72 期号:3 页码:1683-1694
摘要	Six new (1, 2, 3, 5, 6, and 8) and seven known (4, 7, 9, 10, 11, 12, and 13) diterpenoids have been identified in the pulp of Coffea arabica. The structures of new diterpenoids were elucidated by extensive spectroscopic analysis, including 1D, 2D NMR (HSQC, HMBC, H-1-H-1 COSY, and ROESY), HRESIMS, IR, DP4+, electronic circular dichroism, and X-ray crystallography analysis. Compound 1 is ent-labdane-type diterpenoid, whereas compounds (2-13) are ent-kaurane diterpenoids. The result of alpha-glucosidase inhibitory assay demonstrated that compounds (1, 3, 5, 7, and 10) have moderate inhibitory activity with IC50 values of 55.23 +/- 0.84, 74.02 +/- 0.89, 66.46 +/- 1.05, 49.70 +/- 1.02, and 76.34 +/- 0.46 mu M, respectively, compared to the positive control (acarbose, 51.62 +/- 0.21 mu M). Furthermore, molecular docking analysis has been conducted to investigate the interaction between the compounds and the receptors of alpha-glucosidase to interpret their mechanism of activity. This study is the first investigation that successfully discovered the presence of diterpenoids within the coffee pulp.
关键词	Coffeaarabica coffee pulp diterpenoids structure elucidation alpha-glucosidase moleculardocking ENT-KAURANE DITERPENES ACID PRODUCTS EXTRACTS CAFFEINE CAFESTOL ESTERS BEANS
学科领域	342
DOI	10.1021/acs.jafc.3c05619
收录类别	SCI
WOS记录号	WOS:001150570700001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75298
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Al-Romaima,Abdulbaset,Hu,Guilin,Wang,Yanbing,et al. Identification of New Diterpenoids from the Pulp of Coffea arabica and Their α-Glucosidase Inhibition Activity[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2023,72(3):1683-1694.
APA	Al-Romaima,Abdulbaset,Hu,Guilin,Wang,Yanbing,Quan,Chenxi,Dai,Haopeng,&Qiu,Minghua.(2023).Identification of New Diterpenoids from the Pulp of Coffea arabica and Their α-Glucosidase Inhibition Activity.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,72(3),1683-1694.
MLA	Al-Romaima,Abdulbaset,et al."Identification of New Diterpenoids from the Pulp of Coffea arabica and Their α-Glucosidase Inhibition Activity".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 72.3(2023):1683-1694.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
10.1021_acs.jafc.3c0（8107KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载