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Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy 期刊论文
BIOORGANIC CHEMISTRY, 2023, 卷号: 132, 页码: 106375
作者:  Peng,Xingrong;  Luo,Rongcan;  Ran,Xiaoqian;  Guo,Yarong;  Yao,Yong-Gang;  Qiu,Minghua
浏览  |  Adobe PDF(3003Kb)  |  收藏  |  浏览/下载：57/11  |  提交时间：2024/07/22
Ganoderma  Ganoderma applanatum  Triterpenoid  Autophagy  Tau pathology  Alzheimer?s disease  LANOSTANE-TYPE TRITERPENOIDS  ALZHEIMERS-DISEASE  FRUITING BODIES  NEURODEGENERATION  ACID  
Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2023, 卷号: 21, 期号: 3, 页码: 514-519
作者:  Yan,Ying;  Ran,Xiaoqian;  Wang,Dan;  Zhang,Xiong;  Peng,Mingyou;  Yan,Xiaoyan;  Tang,Lei;  Liang,Hong;  Qin,Xujie;  Di,Ying-Tong;  Luo,Rongcan;  Hao,Xiao-Jiang;  Yao,Yong-Gang
浏览  |  Adobe PDF(1471Kb)  |  收藏  |  浏览/下载：63/14  |  提交时间：2024/07/25
UBIQUITIN-PROTEASOME SYSTEM  ALZHEIMERS-DISEASE  CONSTITUENTS  LIMONOIDS  TFEB  NEURODEGENERATION  
ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 22, 页码: e2220148120
作者:  Zhou,Gui-Feng;  Tang,Jing;  Ma,Yuan-Lin;  Fu,Xian;  Liu,Jun-Yan;  Yang,Ren-Zhi;  Zhang,Hong-Sheng;  Cai,Xiang-Hai;  Wang,Jing-Wen;  Xie,Xiao-Yong;  Song,Li;  Luo,Biao;  Chen,Jian;  Chen,Long;  Deng,Xiao-Juan;  Chen,Guo-Jun
浏览  |  Adobe PDF(6685Kb)  |  收藏  |  浏览/下载：112/18  |  提交时间：2024/05/09
conophylline  ARL6IP1  5'UTR  FXR1  BACE1 translation  AMYLOID PRECURSOR PROTEIN  A-BETA  TRANSGENIC MICE  MOUSE MODEL  NEURODEGENERATION  EXPRESSION  REDUCTION  MEMBRANE  MEMORY  ER  
Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway 期刊论文
HELIYON, 2023, 卷号: 9, 期号: 2, 页码: e13691
作者:  Ran,Xiaoqian;  Lu,Qing-Yun;  Li,Ying-Yao;  Pu,Xue-Xue;  Guo,Yarong;  Yuan,Ming-Rui;  Guan,Shi-Peng;  Sun,Mao;  Jiao,Lijin;  Yao,Yong-Gang;  Di,Ying-Tong;  Hao,Xiao-Jiang;  Luo,Rongcan
浏览  |  Adobe PDF(10283Kb)  |  收藏  |  浏览/下载：56/22  |  提交时间：2024/07/30
Euphorbia peplus L  Euphorbiaceae  Ent-abietane diterpenoid  Euphejolkinolide A  Autophagy-lysosomal pathway  ALZHEIMERS-DISEASE  TAU PATHOLOGY  NEURODEGENERATION  DITERPENOIDS  INHIBITION  MECHANISMS  APOPTOSIS  CELASTROL  PROTEIN  SYSTEM  
Tianma modulates proteins with various neuro-regenerative modalities in differentiated human neuronal SH-SY5Y cells 期刊论文
NEUROCHEMISTRY INTERNATIONAL, 2012, 卷号: 60, 期号: 8, 页码: 827-836
作者:  Ramachandran, Umamaheswari;  Manavalan, Arulmani;  Sundaramurthi, Husvinee;  Sze, Siu Kwan;  Feng, Zhi Wei;  Hu, Jiang-Miao;  Heese, Klaus
浏览  |  Adobe PDF(1419Kb)  |  收藏  |  浏览/下载：454/124  |  提交时间：2012/09/03
Tianma  Neuron  Herb  Tcm  Itraq  Neurodegeneration  
New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics 期刊论文
JOURNAL OF PROTEOMICS, 2012, 卷号: 75, 期号: 8, 页码: 2468-2479
作者:  Manavalan, Arulmani;  Feng, Lin;  Sze, Siu Kwan;  Hu, Jiang-Miao;  Heese, Klaus
浏览  |  Adobe PDF(1497Kb)  |  收藏  |  浏览/下载：623/201  |  提交时间：2012/09/03
Aging  Tianma  Neurodegeneration  Metabolism  Signaling  
Gastrodia elata modulates amyloid precursor protein cleavage and cognitive functions in mice 期刊论文
BIOSCIENCE TRENDS, 2011, 卷号: 5, 期号: 3, 页码: 129-138
作者:  Mishra, Manisha;  Huang, Junjie;  Lee, Yin Yeng;  Chua, Doreen See Kin;  Lin, Xiaoyan;  Hu, Jiang-Miao;  Heese, Klaus
浏览  |  Adobe PDF(389Kb)  |  收藏  |  浏览/下载：205/62  |  提交时间：2015/08/17
Alzheimer's Disease  Beta-amyloid Precursor Protein  Kampo  Neurodegeneration  Traditional Chinese Medicine