| Tianma modulates proteins with various neuro-regenerative modalities in differentiated human neuronal SH-SY5Y cells | |
Ramachandran, Umamaheswari1,2; Manavalan, Arulmani1,2; Sundaramurthi, Husvinee1; Sze, Siu Kwan1; Feng, Zhi Wei1; Hu, Jiang-Miao3 ; Heese, Klaus1,2
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| 通讯作者 | Heese, K (reprint author), Nanyang Technol Univ, Sch Biol Sci, 60 Nanyang Dr, Singapore 637551, Singapore. ; Klaus.Heese@rub.de |
| 2012-06-01 | |
| 发表期刊 | NEUROCHEMISTRY INTERNATIONAL
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| ISSN | 0197-0186 |
| 卷号 | 60期号:8页码:827-836 |
| 摘要 | Tianma (Rhizome gastrodiae) is the dried rhizome of the plant Gastrodia elate Blume (Orchidaceae family). As a medicinal herb in traditional Chinese medicine (TCM) its functions are to control convulsions, pain, headache, dizziness, vertigo, seizure, epilepsy and others. In addition, tianma is frequently used for the treatment of neurodegenerative disorders though the mechanism of action is widely unknown. Accordingly, this study was designed to examine the effects of tianma on the proteome metabolism in differentiated human neuronal SH-SY5Y cells to explore its specific effects on neuronal signaling pathways. Using an iTRAQ (isobaric tags for relative and absolute quantitation)-based proteomics research approach, we identified 2390 modulated proteins, out of which 406 were found to be altered by tianma in differentiated human neuronal SH-SY5Y cells. Based on the observed data, we hypothesize that tianma promotes neuro-regenerative signaling cascades by controlling chaperone/proteasomal degradation pathways (e.g. CALR, FKBP3/4, HSP70/90) and mobilizing neuro-protective genes (such as AIP5) as well as modulating other proteins (RTN1/4, NCAM, PACSIN2, and PDLIM1/5) with various regenerative modalities and capacities related to neuro-synaptic plasticity. (C) 2012 Elsevier Ltd. All rights reserved. |
| 关键词 | Tianma Neuron Herb Tcm Itraq Neurodegeneration |
| 学科领域 | Biochemistry & Molecular Biology ; Neurosciences |
| DOI | 10.1016/j.neuint.2012.03.012 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000306036400012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/15083 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore 2.Nanyang Technol Univ, Inst Adv Studies, Singapore 639673, Singapore 3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ramachandran, Umamaheswari,Manavalan, Arulmani,Sundaramurthi, Husvinee,et al. Tianma modulates proteins with various neuro-regenerative modalities in differentiated human neuronal SH-SY5Y cells[J]. NEUROCHEMISTRY INTERNATIONAL,2012,60(8):827-836. |
| APA | Ramachandran, Umamaheswari.,Manavalan, Arulmani.,Sundaramurthi, Husvinee.,Sze, Siu Kwan.,Feng, Zhi Wei.,...&Heese, Klaus.(2012).Tianma modulates proteins with various neuro-regenerative modalities in differentiated human neuronal SH-SY5Y cells.NEUROCHEMISTRY INTERNATIONAL,60(8),827-836. |
| MLA | Ramachandran, Umamaheswari,et al."Tianma modulates proteins with various neuro-regenerative modalities in differentiated human neuronal SH-SY5Y cells".NEUROCHEMISTRY INTERNATIONAL 60.8(2012):827-836. |
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