Tianma modulates proteins with various neuro-regenerative modalities in differentiated human neuronal SH-SY5Y cells
Ramachandran, Umamaheswari1,2; Manavalan, Arulmani1,2; Sundaramurthi, Husvinee1; Sze, Siu Kwan1; Feng, Zhi Wei1; Hu, Jiang-Miao3; Heese, Klaus1,2
2012-06-01
发表期刊NEUROCHEMISTRY INTERNATIONAL
ISSN0197-0186
卷号60期号:8页码:827-836
摘要Tianma (Rhizome gastrodiae) is the dried rhizome of the plant Gastrodia elate Blume (Orchidaceae family). As a medicinal herb in traditional Chinese medicine (TCM) its functions are to control convulsions, pain, headache, dizziness, vertigo, seizure, epilepsy and others. In addition, tianma is frequently used for the treatment of neurodegenerative disorders though the mechanism of action is widely unknown. Accordingly, this study was designed to examine the effects of tianma on the proteome metabolism in differentiated human neuronal SH-SY5Y cells to explore its specific effects on neuronal signaling pathways. Using an iTRAQ (isobaric tags for relative and absolute quantitation)-based proteomics research approach, we identified 2390 modulated proteins, out of which 406 were found to be altered by tianma in differentiated human neuronal SH-SY5Y cells. Based on the observed data, we hypothesize that tianma promotes neuro-regenerative signaling cascades by controlling chaperone/proteasomal degradation pathways (e.g. CALR, FKBP3/4, HSP70/90) and mobilizing neuro-protective genes (such as AIP5) as well as modulating other proteins (RTN1/4, NCAM, PACSIN2, and PDLIM1/5) with various regenerative modalities and capacities related to neuro-synaptic plasticity. (C) 2012 Elsevier Ltd. All rights reserved.
关键词Tianma Neuron Herb Tcm Itraq Neurodegeneration
资助信息Institute of Advanced Studies, Nanyang Technological University
学科领域Biochemistry & Molecular Biology ; Neurosciences
DOI10.1016/j.neuint.2012.03.012
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Neurosciences & Neurology
WOS类目Biochemistry & Molecular Biology ; Neurosciences
WOS记录号WOS:000306036400012
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被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15083
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore
2.Nanyang Technol Univ, Inst Adv Studies, Singapore 639673, Singapore
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
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Ramachandran, Umamaheswari,Manavalan, Arulmani,Sundaramurthi, Husvinee,et al. Tianma modulates proteins with various neuro-regenerative modalities in differentiated human neuronal SH-SY5Y cells[J]. NEUROCHEMISTRY INTERNATIONAL,2012,60(8):827-836.
APA Ramachandran, Umamaheswari.,Manavalan, Arulmani.,Sundaramurthi, Husvinee.,Sze, Siu Kwan.,Feng, Zhi Wei.,...&Heese, Klaus.(2012).Tianma modulates proteins with various neuro-regenerative modalities in differentiated human neuronal SH-SY5Y cells.NEUROCHEMISTRY INTERNATIONAL,60(8),827-836.
MLA Ramachandran, Umamaheswari,et al."Tianma modulates proteins with various neuro-regenerative modalities in differentiated human neuronal SH-SY5Y cells".NEUROCHEMISTRY INTERNATIONAL 60.8(2012):827-836.
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