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题名: Tianma modulates proteins with various neuro-regenerative modalities in differentiated human neuronal SH-SY5Y cells
作者: Ramachandran, Umamaheswari1, 2; Manavalan, Arulmani1, 2; Sundaramurthi, Husvinee1; Sze, Siu Kwan1; Feng, Zhi Wei1; Hu, Jiang-Miao3; Heese, Klaus1, 2
刊名: NEUROCHEMISTRY INTERNATIONAL
关键词: Tianma ; Neuron ; Herb ; TCM ; iTRAQ ; Neurodegeneration
英文摘要: Tianma (Rhizome gastrodiae) is the dried rhizome of the plant Gastrodia elate Blume (Orchidaceae family). As a medicinal herb in traditional Chinese medicine (TCM) its functions are to control convulsions, pain, headache, dizziness, vertigo, seizure, epilepsy and others. In addition, tianma is frequently used for the treatment of neurodegenerative disorders though the mechanism of action is widely unknown. Accordingly, this study was designed to examine the effects of tianma on the proteome metabolism in differentiated human neuronal SH-SY5Y cells to explore its specific effects on neuronal signaling pathways. Using an iTRAQ (isobaric tags for relative and absolute quantitation)-based proteomics research approach, we identified 2390 modulated proteins, out of which 406 were found to be altered by tianma in differentiated human neuronal SH-SY5Y cells. Based on the observed data, we hypothesize that tianma promotes neuro-regenerative signaling cascades by controlling chaperone/proteasomal degradation pathways (e.g. CALR, FKBP3/4, HSP70/90) and mobilizing neuro-protective genes (such as AIP5) as well as modulating other proteins (RTN1/4, NCAM, PACSIN2, and PDLIM1/5) with various regenerative modalities and capacities related to neuro-synaptic plasticity. (C) 2012 Elsevier Ltd. All rights reserved.
出版日期: 2012-06-01
卷号: 60, 期号:8, 页码:827-836
语种: 英语
收录类别: SCI
学科分类: Biochemistry & Molecular Biology; Neurosciences
ISSN号: 0197-0186
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15083
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore
2.Nanyang Technol Univ, Inst Adv Studies, Singapore 639673, Singapore
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China

Recommended Citation:
Ramachandran, Umamaheswari; Manavalan, Arulmani; Sundaramurthi, Husvinee; Sze, Siu Kwan; Feng, Zhi Wei; Hu, Jiang-Miao; Heese, Klaus.Tianma modulates proteins with various neuro-regenerative modalities in differentiated human neuronal SH-SY5Y cells,NEUROCHEMISTRY INTERNATIONAL,2012,60(8):827-836
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