| Gastrodia elata modulates amyloid precursor protein cleavage and cognitive functions in mice | |
Mishra, Manisha1,2; Huang, Junjie2; Lee, Yin Yeng2; Chua, Doreen See Kin2; Lin, Xiaoyan2; Hu, Jiang-Miao3 ; Heese, Klaus1,2
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| 2011 | |
| 发表期刊 | BIOSCIENCE TRENDS
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| 卷号 | 5期号:3页码:129-138 |
| 摘要 | Gastrodia elata (Tianma) is a traditional Chinese medicine often used for the treatment of headache, convulsions, hypertension, and cardiovascular diseases. The vasodilatory actions of Tianma led us to investigate its specific effects on memory and learning as well as on Alzheimer's disease (AD)-related signaling. We conducted a radial arm water maze analysis and the novel object recognition test to assess the cognitive functions of Tianma-treated mice. Our data show that Tianma enhances cognitive functions in mice. Further investigations revealed that Tianma enhances the alpha-secretase-mediated proteolytic processing of the amyloid precursor protein (App) that precludes the amyloid-beta peptide production and supports the non-amyloidogenic processing of App which is favorable in AD treatment. We hypothesize that Tianma promotes cognitive functions and neuronal survival by inhibiting beta-site App-cleaving enzyme 1 activity and promoting the neuroprotective alpha-secretase activity. |
| 关键词 | Alzheimer's Disease Beta-amyloid Precursor Protein Kampo Neurodegeneration Traditional Chinese Medicine |
| DOI | 10.5582/bst.2011.v5.3.129 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000301180300007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/23945 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Nanyang Technol Univ, Sch Biol Sci, Coll Sci, Dept Mol & Cell Biol, Singapore 637551, Singapore 2.Nanyang Technol Univ, Inst Adv Studies, Singapore 637551, Singapore 3.Chinese Acad Sci, Kunming Inst Bot, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mishra, Manisha,Huang, Junjie,Lee, Yin Yeng,et al. Gastrodia elata modulates amyloid precursor protein cleavage and cognitive functions in mice[J]. BIOSCIENCE TRENDS,2011,5(3):129-138. |
| APA | Mishra, Manisha.,Huang, Junjie.,Lee, Yin Yeng.,Chua, Doreen See Kin.,Lin, Xiaoyan.,...&Heese, Klaus.(2011).Gastrodia elata modulates amyloid precursor protein cleavage and cognitive functions in mice.BIOSCIENCE TRENDS,5(3),129-138. |
| MLA | Mishra, Manisha,et al."Gastrodia elata modulates amyloid precursor protein cleavage and cognitive functions in mice".BIOSCIENCE TRENDS 5.3(2011):129-138. |
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| mishra2011.pdf（389KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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