| New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics | |
Manavalan, Arulmani1,2; Feng, Lin2; Sze, Siu Kwan2; Hu, Jiang-Miao3 ; Heese, Klaus1,2
| |
| 通讯作者 | Heese, K (reprint author), Nanyang Technol Univ, Inst Adv Studies, 60 Nanyang View, Singapore 639673, Singapore. ; klaus.heese@rub.de |
| 2012-04-18 | |
| 发表期刊 | JOURNAL OF PROTEOMICS
 |
| ISSN | 1874-3919 |
| 卷号 | 75期号:8页码:2468-2479 |
| 摘要 | Gastrodia elata (tianma) is a traditional Chinese herbal medicine (TCM) often used for the treatment of cerebrovascular diseases. In this study, we investigated the effects of tianma on the brain protein metabolism by quantitative proteomics to gain evidence for a direct relationship between tianma treatment and brain functions. One-year-old rats were treated with tianma (similar to 2.5 g/kg/day) for 3 months and the brain tissue proteome was analyzed by using the iTRAQ (isobaric tag for relative and absolute quantification) technology. According to our results, the long-term treatment with tianma could modulate the brain protein metabolism at the proteome level by down-regulating the expressions of various proteins, such as Gnaol and Dctn2, which are related to neuronal growth cone control and synaptic activities. In addition, tianma treatment also induced the up-regulation of molecular chaperons and proteins related to the misfolded protein response, like Anxa5, and also other proteins involved in Huntington's disease (HD) (e.g. Pacsin1 and Arf3). Concluding, tianma could eventually contribute to activities related to synaptic plasticity and neurorestorative processes and thus might be a novel candidate agent for the treatment of neurodegenerative diseases by regulating the brain proteome. (C) 2012 Elsevier B.V. All rights reserved. |
| 关键词 | Aging Tianma Neurodegeneration Metabolism Signaling |
| 学科领域 | Biochemical Research Methods |
| DOI | 10.1016/j.jprot.2012.02.029 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000303974800017 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/15099 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Nanyang Technol Univ, Inst Adv Studies, Singapore 639673, Singapore 2.Nanyang Technol Univ, Coll Sci, Sch Biol Sci, Singapore 637551, Singapore 3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Manavalan, Arulmani,Feng, Lin,Sze, Siu Kwan,et al. New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics[J]. JOURNAL OF PROTEOMICS,2012,75(8):2468-2479. |
| APA | Manavalan, Arulmani,Feng, Lin,Sze, Siu Kwan,Hu, Jiang-Miao,&Heese, Klaus.(2012).New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics.JOURNAL OF PROTEOMICS,75(8),2468-2479. |
| MLA | Manavalan, Arulmani,et al."New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics".JOURNAL OF PROTEOMICS 75.8(2012):2468-2479. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Manavalan-2012-New i（1497KB） | 开放获取 | -- | 浏览 下载 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论