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题名: New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics
作者: Manavalan, Arulmani1, 2; Feng, Lin2; Sze, Siu Kwan2; Hu, Jiang-Miao3; Heese, Klaus1, 2
刊名: JOURNAL OF PROTEOMICS
关键词: Aging ; Tianma ; Neurodegeneration ; Metabolism ; Signaling
英文摘要: Gastrodia elata (tianma) is a traditional Chinese herbal medicine (TCM) often used for the treatment of cerebrovascular diseases. In this study, we investigated the effects of tianma on the brain protein metabolism by quantitative proteomics to gain evidence for a direct relationship between tianma treatment and brain functions. One-year-old rats were treated with tianma (similar to 2.5 g/kg/day) for 3 months and the brain tissue proteome was analyzed by using the iTRAQ (isobaric tag for relative and absolute quantification) technology. According to our results, the long-term treatment with tianma could modulate the brain protein metabolism at the proteome level by down-regulating the expressions of various proteins, such as Gnaol and Dctn2, which are related to neuronal growth cone control and synaptic activities. In addition, tianma treatment also induced the up-regulation of molecular chaperons and proteins related to the misfolded protein response, like Anxa5, and also other proteins involved in Huntington's disease (HD) (e.g. Pacsin1 and Arf3). Concluding, tianma could eventually contribute to activities related to synaptic plasticity and neurorestorative processes and thus might be a novel candidate agent for the treatment of neurodegenerative diseases by regulating the brain proteome. (C) 2012 Elsevier B.V. All rights reserved.
出版日期: 2012-04-18
卷号: 75, 期号:8, 页码:2468-2479
DOI标识: 10.1016/j.jprot.2012.02.029
语种: 英语
ISSN号: 1874-3919
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15099
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Nanyang Technol Univ, Inst Adv Studies, Singapore 639673, Singapore
2.Nanyang Technol Univ, Coll Sci, Sch Biol Sci, Singapore 637551, Singapore
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China

Recommended Citation:
Manavalan, Arulmani; Feng, Lin; Sze, Siu Kwan; Hu, Jiang-Miao; Heese, Klaus.New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics,JOURNAL OF PROTEOMICS,2012,75(8):2468-2479
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