New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics
Manavalan, Arulmani1,2; Feng, Lin2; Sze, Siu Kwan2; Hu, Jiang-Miao3; Heese, Klaus1,2
2012-04-18
发表期刊JOURNAL OF PROTEOMICS
ISSN1874-3919
卷号75期号:8页码:2468-2479
摘要Gastrodia elata (tianma) is a traditional Chinese herbal medicine (TCM) often used for the treatment of cerebrovascular diseases. In this study, we investigated the effects of tianma on the brain protein metabolism by quantitative proteomics to gain evidence for a direct relationship between tianma treatment and brain functions. One-year-old rats were treated with tianma (similar to 2.5 g/kg/day) for 3 months and the brain tissue proteome was analyzed by using the iTRAQ (isobaric tag for relative and absolute quantification) technology. According to our results, the long-term treatment with tianma could modulate the brain protein metabolism at the proteome level by down-regulating the expressions of various proteins, such as Gnaol and Dctn2, which are related to neuronal growth cone control and synaptic activities. In addition, tianma treatment also induced the up-regulation of molecular chaperons and proteins related to the misfolded protein response, like Anxa5, and also other proteins involved in Huntington's disease (HD) (e.g. Pacsin1 and Arf3). Concluding, tianma could eventually contribute to activities related to synaptic plasticity and neurorestorative processes and thus might be a novel candidate agent for the treatment of neurodegenerative diseases by regulating the brain proteome. (C) 2012 Elsevier B.V. All rights reserved.
关键词Aging Tianma Neurodegeneration Metabolism Signaling
资助信息Institute of Advanced Studies, Nanyang Technological University
学科领域Biochemical Research Methods
DOI10.1016/j.jprot.2012.02.029
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology
WOS类目Biochemical Research Methods
WOS记录号WOS:000303974800017
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15099
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Nanyang Technol Univ, Inst Adv Studies, Singapore 639673, Singapore
2.Nanyang Technol Univ, Coll Sci, Sch Biol Sci, Singapore 637551, Singapore
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
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Manavalan, Arulmani,Feng, Lin,Sze, Siu Kwan,et al. New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics[J]. JOURNAL OF PROTEOMICS,2012,75(8):2468-2479.
APA Manavalan, Arulmani,Feng, Lin,Sze, Siu Kwan,Hu, Jiang-Miao,&Heese, Klaus.(2012).New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics.JOURNAL OF PROTEOMICS,75(8),2468-2479.
MLA Manavalan, Arulmani,et al."New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics".JOURNAL OF PROTEOMICS 75.8(2012):2468-2479.
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