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High throughput-screening of native herbal compounds identifies taccaoside A as a cytotoxic compound that mediates RAS signaling in cancer stem cells 期刊论文
PHYTOMEDICINE, 2023, 卷号: 108, 页码: 154492
作者:  Yang,Dong;  Dai,Zhi;  Zhu,Peifeng;  Wang,Gan;  Sun,Bin;  Li,Shirong;  Hao,Junjun;  Wang,Yifen;  Liu,Yaping;  Yu,Shuaishuai;  Lai,Ren;  Luo,Xiao-Dong;  Zhao,Xudong
浏览  |  Adobe PDF(6987Kb)  |  收藏  |  浏览/下载：72/11  |  提交时间：2024/07/17
Natural product  Furostanol saponin  Taccaoside A  Cancer stem cell  RAS  STEROIDAL SAPONINS  NATURAL-PRODUCTS  PI3K/AKT  PROLIFERATION  MAINTENANCE  STATISTICS  MAPK/ERK  
Guaiane-type Sesquiterpenoid Dimers from Artemisia zhongdianensis and Antihepatoma Carcinoma Activity via the p38MAPK Pathway 期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2023, 卷号: 41, 期号: 19, 页码: 2453-2468
作者:  Dong,Wei;  Ma,Wen-Jing;  Ma,Yun-Bao;  Li,Feng-Jiao;  Li,Tian-Ze;  Wang,Yong-Cui;  He,Xiao-Feng;  Geng,Chang-An;  Zhang,Xue-Mei;  Chen,Ji-Jun
浏览  |  Adobe PDF(3816Kb)  |  收藏  |  浏览/下载：44/15  |  提交时间：2024/07/10
Artemzhongdianolides B1-B17  Artemisia zhongdianensis  Guaiane-type sesquiterpenoid dimers  Antihepatoma activity  p38MAPK pathway  Cancer  NMR spectroscopy  X-ray diffraction  ARREST  CELLS  JNK  
Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 9, 页码: 8113
作者:  Xu,Xinglian;  Deng,Lulu;  Tang,Yaling;  Li,Jiang;  Zhong,Ting;  Hao,Xiaojiang;  Fan,Yanhua;  Mu,Shuzhen
浏览  |  Adobe PDF(5829Kb)  |  收藏  |  浏览/下载：70/17  |  提交时间：2024/05/09
leukemia  sanguinarine  c-MET  MAPK  PI3K/mTOR  STAT3  MET  
Anti-Inflammatory Effects of Camellia fascicularis Polyphenols via Attenuation of NF-kappa B and MAPK Pathways in LPS-Induced THP-1 Macrophages 期刊论文
JOURNAL OF INFLAMMATION RESEARCH, 2022, 卷号: 15, 页码: 851-864
作者:  Gao, Miaozi;  Peng, Xiaowei;  Tang, Junrong;  Deng, Jia;  Wang, Fang;  Zhang, Yingjun;  Zhao, Ping;  Kan, Huan;  Liu, Yun
浏览  |  Adobe PDF(9145Kb)  |  收藏  |  浏览/下载：100/27  |  提交时间：2024/04/30
Camellia fascicularis  polyphenols  anti-inflammatory activity  NF-kappa B  MAPK  LIPOPOLYSACCHARIDE-INDUCED INFLAMMATION  OXIDATIVE STRESS  CELLS  SUPPRESSION  ANTIOXIDANT  ACTIVATION  NRF2/HO-1  RESPONSES  PROTEIN  CANCER  
Discovery and synthesis of rocaglaol derivatives inducing apoptosis in HCT116 cells via suppression of MAPK signaling pathway 期刊论文
FITOTERAPIA, 2021, 卷号: 151, 页码: 104876
作者:  Yang,Hao-Jie;  Li,Ya-Nan;  Yan,Chen;  Yang,Jue;  Zeng,Yan-Rong;  Yi,Ping;  Li,Yan-Mei;  Hao,Xiao-Jiang;  Yuan,Chun-Mao
浏览  |  Adobe PDF(2804Kb)  |  收藏  |  浏览/下载：117/31  |  提交时间：2022/04/02
Dysoxylum gotadhora  Rocaglaol derivatives  HCT116  Cytotoxic activity  MAPK pathway  FLAVAGLINES  
Acetyl-macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti-cancer effects with the Chk1/2 inhibitor AZD7762 期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 卷号: 365, 页码: 71-83
作者:  Wang, Jing-Nan;  Che, Yun;  Yuan, Zu-Yang;  Lu, Zhi-Liang;  Li, Yuan;  Zhang, Zhi-Rong;  Li, Ning;  Li, Ren-Da;  Wan, Jun;  Sun, Han-Dong;  Sun, Nan;  Puno, Pema-Tenzin;  He, Jie
浏览  |  Adobe PDF(3457Kb)  |  收藏  |  浏览/下载：387/86  |  提交时间：2019/03/18
Acetyl-macrocalin B  Reactive oxygen species  p38 MAPK  Chk1/Chk2  Esophageal squamous cell carcinoma  
Inhibitory effect of different Dendrobium species on LPS-induced inflammation in macrophages via suppression of MAPK pathways 期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2018, 卷号: 16, 期号: 7, 页码: 481-489
作者:  Zeng Qiang;  Ko, Chun-Hay;  Siu, Wing-Sum;  Li Kai-Kai;  Wong, Chun-Wai;  Han Xiao-Qiang;  Yang Liu;  Lau, Clara Bik-San;  Hu Jiang-Miao;  Leung, Ping-Chung
收藏  |  浏览/下载：142/0  |  提交时间：2018/09/17
Dendrobium Species  Anti-inflammation  Macrophage  Mapk Pathways  
Acetyl-macrocalin B, an ent-kaurane diterpenoid, initiates apoptosis through the ROS-p38-caspase 9-dependent pathway and induces G2/M phase arrest via the Chk1/2-Cdc25C-Cdc2/cyclin B axis in non-small cell lung cancer 期刊论文
CANCER BIOLOGY & THERAPY, 2018, 卷号: 19, 期号: 7, 页码: 609-621
作者:  Wang, Jing-Nan;  Zhang, Zhi-Rong;  Che, Yun;  Yuan, Zu-Yang;  Lu, Zhi-Liang;  Li, Yuan;  Li, Ning;  Wan, Jun;  Sun, Han-Dong;  Sun, Nan;  Puno, Pema-Tenzin;  He, Jie
收藏  |  浏览/下载：248/0  |  提交时间：2018/07/16
Acetyl-macrocalin B  reactive oxygen species  p38 MAPK  apoptosis  Chk1  Chk2  G2  M phase arrest  NSCLC  
Up-regulation of MPK4 increases the feeding efficiency of the green peach aphid under elevated CO2 in Nicotiana attenuata 期刊论文
JOURNAL OF EXPERIMENTAL BOTANY, 2017, 卷号: 68, 期号: 21-22, 页码: 5923-5935
作者:  Guo, Huijuan;  Peng, Xinhong;  Gu, Liyuan;  Wu, Jianqiang;  Ge, Feng;  Sun, Yucheng
浏览  |  Adobe PDF(3738Kb)  |  收藏  |  浏览/下载：501/60  |  提交时间：2018/05/08
Elevated Co2  Feeding Behaviour  Jasmonic Acid  Mapk  Myzus Persicae  Nicotiana Attenuata  Stomatal Closure  
MAPK signaling: A key element in plant defense response to insects 期刊论文
INSECT SCIENCE, 2015, 卷号: 22, 期号: 2, 页码: 157-164
作者:  Hettenhausen, Christian;  Schuman, Meredith C.;  Wu, Jianqiang;  Wu,JQ (reprint author),Chinese Acad Sci,Kunming Inst Bot,Lanhei Rd 132,Kunming 650201,Yunnan,Peoples R China.;  wujianqiang@mail.kib.ac.cn
浏览  |  Adobe PDF(150Kb)  |  收藏  |  浏览/下载：380/90  |  提交时间：2015/06/09
Defense  Fac  Insect  Jasmonate  Mitogen-activated Protein Kinase (Mapk)  Plant-insect Interaction