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Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii 期刊论文
PHYTOMEDICINE, 2023, 卷号: 121, 页码: 155054
作者:  Dai,Manyun;  Peng,Wan;  Lin,Lisha;  Wu,Zhanxuan;  Zhang,Ting;  Zhao,Qi;  Cheng,Yan;  Lin,Qiuxia;  Zhang,Binbin;  Liu,Aiming;  Rao,Qianru;  Huang,Jianfeng;  Zhao,Jinhua;  Gonzalez,Frank J.;  Li,Fei
浏览  |  Adobe PDF(17974Kb)  |  收藏  |  浏览/下载：69/19  |  提交时间：2024/07/17
Intestinal bleeding  Triptolide  Celastrol  Intestinal FXR  Tripterygium wilfordii  FARNESOID-X-RECEPTOR  BACTERIAL TRANSLOCATION  ACTIVATION  INFLAMMATION  DYSFUNCTION  TRIPTOLIDE  MICROBIOTA  PREVENTS  OBESITY  MICE  
ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 22, 页码: e2220148120
作者:  Zhou,Gui-Feng;  Tang,Jing;  Ma,Yuan-Lin;  Fu,Xian;  Liu,Jun-Yan;  Yang,Ren-Zhi;  Zhang,Hong-Sheng;  Cai,Xiang-Hai;  Wang,Jing-Wen;  Xie,Xiao-Yong;  Song,Li;  Luo,Biao;  Chen,Jian;  Chen,Long;  Deng,Xiao-Juan;  Chen,Guo-Jun
浏览  |  Adobe PDF(6685Kb)  |  收藏  |  浏览/下载：112/18  |  提交时间：2024/05/09
conophylline  ARL6IP1  5'UTR  FXR1  BACE1 translation  AMYLOID PRECURSOR PROTEIN  A-BETA  TRANSGENIC MICE  MOUSE MODEL  NEURODEGENERATION  EXPRESSION  REDUCTION  MEMBRANE  MEMORY  ER  
雷公藤制剂对消化系统的毒性机理研究 学位论文
: 中国科学院大学, 2022
作者:  代曼云
Adobe PDF(10574Kb)  |  收藏  |  浏览/下载：18/0  |  提交时间：2024/05/14
代谢组学，雷公藤，药源性肝损伤，消化性溃疡，FXR，ET-1， 肠道血管屏障  Metabolomics, Tripterygium wilfordii, Drug-induced liver injury, peptic ulcer disease, FXR, ET-1, intestinal vascular barrier.  
Basal PPAR alpha inhibits bile acid metabolism adaptation in chronic cholestatic model induced by alpha-naphthylisothiocyanate 期刊论文
TOXICOLOGY LETTERS, 2019, 卷号: 300, 页码: 31-39
作者:  Hua, Huiying;  Dai, Manyun;  Luo, Yishuang;  Lin, Hante;  Xu, Gangming;  Hu, Xiaowei;  Xu, Liping;  Zhang, Haoyue;  Tang, Zhiyuan;  Chang, Liming;  Liu, Aiming;  Yang, Julin
浏览  |  Adobe PDF(3156Kb)  |  收藏  |  浏览/下载：353/46  |  提交时间：2018/12/18
PPAR alpha  FXR pathway  Alpha-naphthylisothiocyanate  Chronic cholestasis  
Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity 期刊论文
FITOTERAPIA, 2012, 卷号: 83, 期号: 5, 页码: 926-931
作者:  Zou, Juan;  Jiang, Jing;  Diao, Yan-Yan;  Yang, Li-Bin;  Huang, Jin;  Li, Hong-Lin;  Du, Xue;  Xiao, Wei-Lie;  Pu, Jian-Xin;  Sun, Han-Dong
浏览  |  Adobe PDF(813Kb)  |  收藏  |  浏览/下载：322/85  |  提交时间：2014/04/02
Schisandra Glaucescens  Schisandraceae  Cycloartane Triterpenoid  Fxr Agonistic And antAgonistic Effects  
Lanostane Triterpenoids from the Stems of Schisandra glaucescens 期刊论文
PLANTA MEDICA, 2012, 卷号: 78, 期号: 5, 页码: 472-479
作者:  Zou, Juan;  Yang, Li-Bin;  Jiang, Jing;  Diao, Yan-Yan;  Li, Xiao-Nian;  Huang, Jin;  Yang, Jian-Hong;  Li, Hong-Lin;  Xiao, Wei-Lie;  Du, Xue;  Shang, Shan-Zhai;  Pu, Jian-Xin;  Sun, Han-Dong
浏览  |  Adobe PDF(9469Kb)  |  收藏  |  浏览/下载：327/59  |  提交时间：2012/07/26
Lanostane Triterpenoids  Schisandraceae  Schisandra Glaucescens  Fxr