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New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit beta-Amyloid42 Production and Phospho-Tau (Thr217) 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 2, 页码: 1487
作者:  Li,Sheng;  Han,Ling-Ling;  Huang,Ke-Pu;  Ma,Ye-Han;  Guo,Ling-Li;  Guo,Yarong;  Ran,Xiaoqian;  Yao,Yong-Gang;  Hao,Xiao-Jiang;  Luo,Rongcan;  Zhang,Yu
浏览  |  Adobe PDF(5266Kb)  |  收藏  |  浏览/下载：38/12  |  提交时间：2024/05/09
Tabernaemontana crassa  monoterpenoid indole alkaloids  A beta 42  phospho-tau (Thr217)  Alzheimer's disease  ALZHEIMERS-DISEASE  BISINDOLE ALKALOIDS  CDK5  GEMFIBROZIL  PREVENTION  ALGORITHM  AUTOPHAGY  MODELS  PLANTS  MOUSE  
Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy 期刊论文
BIOORGANIC CHEMISTRY, 2023, 卷号: 132, 页码: 106375
作者:  Peng,Xingrong;  Luo,Rongcan;  Ran,Xiaoqian;  Guo,Yarong;  Yao,Yong-Gang;  Qiu,Minghua
浏览  |  Adobe PDF(3003Kb)  |  收藏  |  浏览/下载：2/0  |  提交时间：2024/07/22
Ganoderma  Ganoderma applanatum  Triterpenoid  Autophagy  Tau pathology  Alzheimer?s disease  LANOSTANE-TYPE TRITERPENOIDS  ALZHEIMERS-DISEASE  FRUITING BODIES  NEURODEGENERATION  ACID  
Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom 期刊论文
PHYTOCHEMISTRY, 2019, 卷号: 165, 页码: 8
作者:  Qi, Changxing;  Zhou, Qun;  Gao, Weixi;  Liu, Mengting;  Chen, Chunmei;  Li, Xiao-Nian;  Lai, Yongji;  Zhou, Yuan;  Li, Dongyan;  Hu, Zhengxi;  Zhu, Hucheng;  Zhang, Yonghui
浏览  |  Adobe PDF(1128Kb)  |  收藏  |  浏览/下载：299/156  |  提交时间：2019/10/14
Aspergillus terreus Thom  endophytic fungus  3,5-Dimethylorsellinic acid-based meroterpenoid  Adducts  Alzheimer's disease  
Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 14, 页码: 4218-4224
作者:  Zhu, Jinmei;  Wu, Chun-Feng;  Li, Xiaobing;  Wu, Gui-Sheng;  Xie, Shan;  Hu, Qian-Nan;  Deng, Zixin;  Zhu, Michael X.;  Luo, Huai-Rong;  Hong, Xuechuan
浏览  |  Adobe PDF(1174Kb)  |  收藏  |  浏览/下载：548/94  |  提交时间：2013/10/16
Alzheimer's Disease  Acetylcholinesterase  Butyrylcholinesterase  Molecular Modeling  2-aminobenzimidazole  
Gastrodia elata modulates amyloid precursor protein cleavage and cognitive functions in mice 期刊论文
BIOSCIENCE TRENDS, 2011, 卷号: 5, 期号: 3, 页码: 129-138
作者:  Mishra, Manisha;  Huang, Junjie;  Lee, Yin Yeng;  Chua, Doreen See Kin;  Lin, Xiaoyan;  Hu, Jiang-Miao;  Heese, Klaus
浏览  |  Adobe PDF(389Kb)  |  收藏  |  浏览/下载：160/54  |  提交时间：2015/08/17
Alzheimer's Disease  Beta-amyloid Precursor Protein  Kampo  Neurodegeneration  Traditional Chinese Medicine  
Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 卷号: 17, 期号: 19, 页码: 6937-6941
作者:  Yan, Jian;  Sun, Lirong;  Wu, Guisheng;  Yi, Ping;  Yang, Fumei;  Zhou, Lin;  Zhang, Xianmin;  Li, Zhongrong;  Yang, Xiaosheng;  Luo, Huairong;  Qiu, Minghua
Adobe PDF(368Kb)  |  收藏  |  浏览/下载：452/159  |  提交时间：2012/03/21
Alzheimer's Disease  Hupzine a  Ache  Docking Study