Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom
Qi, Changxing1; Zhou, Qun1; Gao, Weixi1; Liu, Mengting1; Chen, Chunmei1; Li, Xiao-Nian3; Lai, Yongji4; Zhou, Yuan1; Li, Dongyan2; Hu, Zhengxi1; Zhu, Hucheng1; Zhang, Yonghui1
Corresponding AuthorLi, Dongyan(lidongyan2016@sina.com) ; Hu, Zhengxi(hzx616@126.com) ; Zhu, Hucheng(zhuhucheng0@163.com) ; Zhang, Yonghui(zhangyh@mails.tjmu.edu.cn)
2019-09-01
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume165Pages:8
AbstractSpiroterreusnoids A-F, six undescribed spiro-dioxolane-containing adducts bearing 3,5-dimethylorsellinic acid-based meroterpenoid and 2,3-butanediol moieties were isolated from the endophytic fungus Aspergillus terreus Thom from Tripterygium wilfordii Hook. f. (Celastraceae). The structures of these adducts were established by spectroscopy, single-crystal X-ray diffraction, and experimental electronic circular dichroism (ECD) measurements. Spiroterreusnoids A-F represent the first examples of adducts composed of 3,5-dimethylorsellinic acidbased meroterpenoids. It is noteworthy that spiroterreusnoids A-F possessing a spiro-dioxolane moiety exhibited potential abilities in inhibiting BACE1 (IC50 values ranging from 5.86 to 27.16 mu M) and AchE (IC50 values ranging from 22.18 to 32.51 mu M), while the other analogues without this fragment displayed no such activities. Taken together, spiroterreusnoids A-F represent the first multitargeted natural adducts that could inhibit BACE1 and AchE, and might provide a new template for the development of new anti-Alzheimer's disease drugs.
KeywordAspergillus terreus Thom endophytic fungus 3,5-Dimethylorsellinic acid-based meroterpenoid Adducts Alzheimer's disease
DOI10.1016/j.phytochem.2019.05.014
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000482248900005
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/68377
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLi, Dongyan; Hu, Zhengxi; Zhu, Hucheng; Zhang, Yonghui
Affiliation1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
4.Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Dept Pharm, Wuhan, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Qi, Changxing,Zhou, Qun,Gao, Weixi,et al. Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom[J]. PHYTOCHEMISTRY,2019,165:8.
APA Qi, Changxing.,Zhou, Qun.,Gao, Weixi.,Liu, Mengting.,Chen, Chunmei.,...&Zhang, Yonghui.(2019).Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom.PHYTOCHEMISTRY,165,8.
MLA Qi, Changxing,et al."Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom".PHYTOCHEMISTRY 165(2019):8.
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