Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom

doi:10.1016/j.phytochem.2019.05.014

	Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom
	Qi, Changxing 1; Zhou, Qun 1; Gao, Weixi 1; Liu, Mengting 1; Chen, Chunmei 1; Li, Xiao-Nian 3; Lai, Yongji 4; Zhou, Yuan1 ; Li, Dongyan 2; Hu, Zhengxi 1; Zhu, Hucheng 1; Zhang, Yonghui 1
通讯作者	Li, Dongyan(lidongyan2016@sina.com) ; Hu, Zhengxi(hzx616@126.com) ; Zhu, Hucheng(zhuhucheng0@163.com) ; Zhang, Yonghui(zhangyh@mails.tjmu.edu.cn)
	2019-09-01
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	165 页码:8
摘要	Spiroterreusnoids A-F, six undescribed spiro-dioxolane-containing adducts bearing 3,5-dimethylorsellinic acid-based meroterpenoid and 2,3-butanediol moieties were isolated from the endophytic fungus Aspergillus terreus Thom from Tripterygium wilfordii Hook. f. (Celastraceae). The structures of these adducts were established by spectroscopy, single-crystal X-ray diffraction, and experimental electronic circular dichroism (ECD) measurements. Spiroterreusnoids A-F represent the first examples of adducts composed of 3,5-dimethylorsellinic acidbased meroterpenoids. It is noteworthy that spiroterreusnoids A-F possessing a spiro-dioxolane moiety exhibited potential abilities in inhibiting BACE1 (IC50 values ranging from 5.86 to 27.16 mu M) and AchE (IC50 values ranging from 22.18 to 32.51 mu M), while the other analogues without this fragment displayed no such activities. Taken together, spiroterreusnoids A-F represent the first multitargeted natural adducts that could inhibit BACE1 and AchE, and might provide a new template for the development of new anti-Alzheimer's disease drugs.
关键词	Aspergillus terreus Thom endophytic fungus 3,5-Dimethylorsellinic acid-based meroterpenoid Adducts Alzheimer's disease
DOI	10.1016/j.phytochem.2019.05.014
收录类别	SCI
语种	英语
WOS记录号	WOS:000482248900005
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/68377
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Li, Dongyan; Hu, Zhengxi; Zhu, Hucheng; Zhang, Yonghui
作者单位	1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 4.Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Dept Pharm, Wuhan, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Qi, Changxing,Zhou, Qun,Gao, Weixi,et al. Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom[J]. PHYTOCHEMISTRY,2019,165:8.
APA	Qi, Changxing.,Zhou, Qun.,Gao, Weixi.,Liu, Mengting.,Chen, Chunmei.,...&Zhang, Yonghui.(2019).Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom.PHYTOCHEMISTRY,165,8.
MLA	Qi, Changxing,et al."Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom".PHYTOCHEMISTRY 165(2019):8.

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