Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom
Qi, Changxing1; Zhou, Qun1; Gao, Weixi1; Liu, Mengting1; Chen, Chunmei1; Li, Xiao-Nian3; Lai, Yongji4; Zhou, Yuan1; Li, Dongyan2; Hu, Zhengxi1; Zhu, Hucheng1; Zhang, Yonghui1
通讯作者Li, Dongyan(lidongyan2016@sina.com) ; Hu, Zhengxi(hzx616@126.com) ; Zhu, Hucheng(zhuhucheng0@163.com) ; Zhang, Yonghui(zhangyh@mails.tjmu.edu.cn)
2019-09-01
发表期刊PHYTOCHEMISTRY
ISSN0031-9422
卷号165页码:8
摘要Spiroterreusnoids A-F, six undescribed spiro-dioxolane-containing adducts bearing 3,5-dimethylorsellinic acid-based meroterpenoid and 2,3-butanediol moieties were isolated from the endophytic fungus Aspergillus terreus Thom from Tripterygium wilfordii Hook. f. (Celastraceae). The structures of these adducts were established by spectroscopy, single-crystal X-ray diffraction, and experimental electronic circular dichroism (ECD) measurements. Spiroterreusnoids A-F represent the first examples of adducts composed of 3,5-dimethylorsellinic acidbased meroterpenoids. It is noteworthy that spiroterreusnoids A-F possessing a spiro-dioxolane moiety exhibited potential abilities in inhibiting BACE1 (IC50 values ranging from 5.86 to 27.16 mu M) and AchE (IC50 values ranging from 22.18 to 32.51 mu M), while the other analogues without this fragment displayed no such activities. Taken together, spiroterreusnoids A-F represent the first multitargeted natural adducts that could inhibit BACE1 and AchE, and might provide a new template for the development of new anti-Alzheimer's disease drugs.
关键词Aspergillus terreus Thom endophytic fungus 3,5-Dimethylorsellinic acid-based meroterpenoid Adducts Alzheimer's disease
DOI10.1016/j.phytochem.2019.05.014
收录类别SCI
语种英语
WOS记录号WOS:000482248900005
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/68377
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Li, Dongyan; Hu, Zhengxi; Zhu, Hucheng; Zhang, Yonghui
作者单位1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
4.Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Dept Pharm, Wuhan, Hubei, Peoples R China
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Qi, Changxing,Zhou, Qun,Gao, Weixi,et al. Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom[J]. PHYTOCHEMISTRY,2019,165:8.
APA Qi, Changxing.,Zhou, Qun.,Gao, Weixi.,Liu, Mengting.,Chen, Chunmei.,...&Zhang, Yonghui.(2019).Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom.PHYTOCHEMISTRY,165,8.
MLA Qi, Changxing,et al."Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom".PHYTOCHEMISTRY 165(2019):8.
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