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Discovery of novel modulators targeting human TRPC5: Docking-based virtual screening, molecular dynamics simulation and binding af fi nity predication 期刊论文
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2021, 卷号: 102, 页码: 107795
作者:  Liu,Bin;  Zhang,Wei;  Guo,Sheng;  Zuo,Zhili
浏览  |  Adobe PDF(4277Kb)  |  收藏  |  浏览/下载：61/10  |  提交时间：2022/04/02
hTRPC5  Homology modeling  Molecular docking  Molecular dynamics simulation  Virtual screening  INHIBITOR  CHANNELS  GROMACS  POTENT  AMBER  IDENTIFICATION  CONSTRAINTS  INTEGRATION  AMYGDALA  
Identification of Novel TRPC5 Inhibitors by Pharmacophore-Based and Structure-Based Approaches 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2020
作者:  Li, Shuxiang;  Zhang, Shuqun;  Chen, Dingyuan;  Jiang, Xuan;  Liu, Bin;  Zhang, Hongbin;  Rachakunta, Munikishore;  Zuo, Zhili
浏览  |  Adobe PDF(4261Kb)  |  收藏  |  浏览/下载：105/31  |  提交时间：2021/01/05
Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 11, 页码: 4680-4692
作者:  Qu, Chunrong;  Ding, Mingmin;  Zhu, Yingmin;  Lu, Yungang;  Du, Juan;  Miller, Melissa;  Tian, Jinbin;  Zhu, Jinmei;  Xui, Jian;  Wen, Meng;  Er-Bu, Aga;  Wan, Jule;  Xiao, Yuling;  Wu, Meng;  McManus, Owen B.;  Li, Min;  Wu, Jilin;  Luo, Huai-Rong;  Cao, Zhengyu;  Shen, Bing;  Wang, Hongbo;  Zhu, Michael X.;  Hong, Xuechuan
浏览  |  Adobe PDF(1969Kb)  |  收藏  |  浏览/下载：192/76  |  提交时间：2017/08/29
M084抗衰老机制及WWP-1调控脂代谢与衰老机制的研究 学位论文
: 中国科学院大学, 2017
作者:  丁爱军
Adobe PDF(4584Kb)  |  收藏  |  浏览/下载：84/1  |  提交时间：2019/06/14
Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way 期刊论文
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2017, 卷号: 426, 期号: 1-2, 页码: 101-109
作者:  Ding, Ai-Jun;  Wu, Gui-Sheng;  Tang, Bin;  Hong, Xuechuan;  Zhu, Michael X.;  Luo, Huai-Rong
浏览  |  Adobe PDF(557Kb)  |  收藏  |  浏览/下载：232/78  |  提交时间：2017/05/19
Aging  Benzimidazole Derivative M084  Caenorhabditis Elegans  Lifespan  
Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2015, 卷号: 172, 期号: 14, 页码: 3495-3509
作者:  Zhu, Yingmin;  Lu, Yungang;  Qu, Chunrong;  Miller, Melissa;  Tian, Jinbin;  Thakur, Dhananjay P.;  Zhu, Jinmei;  Deng, Zixin;  Hu, Xianming;  Wu, Meng;  McManus, Owen B.;  Li, Min;  Hong, Xuechuan;  Zhu, Michael X.;  Luo, Huai-Rong
浏览  |  Adobe PDF(2298Kb)  |  收藏  |  浏览/下载：174/43  |  提交时间：2015/12/15
TRPC4/C5抑制剂M084抗抑郁作用及机制研究 学位论文
, 昆明: 中国科学院大学, 2015
作者:  杨丽萍
Adobe PDF(3547Kb)  |  收藏  |  浏览/下载：112/3  |  提交时间：2017/06/09
抗抑郁  Trpc4/c5  Bdnf  情绪相关疾病  M084  
Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 14, 页码: 4218-4224
作者:  Zhu, Jinmei;  Wu, Chun-Feng;  Li, Xiaobing;  Wu, Gui-Sheng;  Xie, Shan;  Hu, Qian-Nan;  Deng, Zixin;  Zhu, Michael X.;  Luo, Huai-Rong;  Hong, Xuechuan
浏览  |  Adobe PDF(1174Kb)  |  收藏  |  浏览/下载：522/89  |  提交时间：2013/10/16
Alzheimer's Disease  Acetylcholinesterase  Butyrylcholinesterase  Molecular Modeling  2-aminobenzimidazole