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Target acquisition of anti-aging manno-oligosaccharide that triggers ECM process via TGF-β/Smads-SIRT1 signalling pathway 期刊论文
CARBOHYDRATE POLYMERS, 2023, 卷号: 302, 页码: 120380
作者:  Yang, Liu;  Zi, Chengting;  Chen, Dingkang;  Li, Jinyu;  He, Rui;  Hu, Jiang-Miao
Adobe PDF(9175Kb)  |  收藏  |  浏览/下载：84/12  |  提交时间：2024/07/22
Global consortium for the classification of fungi and fungus-like taxa 期刊论文
MYCOSPHERE, 2023, 卷号: 14, 期号: 1, 页码: 1960-2012
作者:  Hyde,K. D.;  Abdel-Wahab,M. A.;  Abdollahzadeh,J.;  Abeywickrama,P. D.;  Absalan,S.;  Afshari,N.;  Ainsworth,A. M.;  Akulov,O. Y.;  Aleoshin,V. V.;  Al-Sadi,A. M.;  Alvarado,P.;  Alves,A.;  Alves-Silva,G.;  Amalfi,M.;  Amira,Y.;  Amuhenage,T. B.;  Anderson,J. L.;  Antonin,V;  Aouali,S.;  Aptroot,A.;  Apurillo,C. C. S.;  Araujo,J. P. M.;  Ariyawansa,H. A.;  Armand,A.;  Arumugam,E.;  Asghari,R.;  Assis,D. M. A.;  Atienza,V;  Avasthi,S.;  Azevedo,E.;  Bahkali,A. H.;  Bakhshi,M.;  Banihashemi,Z.;  Bao,D. F.;  Baral,H. O.;  Barata,M.;  Barbosa,F. R.;  Barbosa,R. N.;  Barreto,R. W.;  Baschien,C.;  Belamesiatseva,D. B.;  Bennett Reuel,M.;  Bera,I;  Bezerra,J. D. P.;  Bezerra,J. L.;  Bhat,D. J.;  Bhunjun,C. S.;  Bianchinotti,M.,V;  Blaszkowski,J.;  Blondelle,A.;  Boekhout,T.;  Bonito,G.;  Boonmee,S.;  Boonyuen,N.;  Bregant,C.;  Buchanan,P.;  Bundhun,D.;  Burgaud,G.;  Burgess,T.;  Buyck,B.;  Cabarroi-Hernandez,M.;  Caceres,M. E. S.;  Caeiro,M. F.;  Cai,L.;  Cai,M. F.;  Calabon,M. S.;  Calaca,F. J. S.;  Callalli,M.;  Camara,M. P. S.;  Cano-Lira,J. F.;  Cantillo,T.;  Cao,B.;  Carlavilla,J. R.;  Carvalho,A.;  Castaneda-Ruiz,R. F.;  Castlebury,L.;  Castro-Jauregui,O.;  Catania,M. D.,V;  Cavalcanti,L. H.;  Cazabonne,J.;  Cedeno-Sanchez,M. L.;  Chaharmiri-Dokhaharani,S.;  Chaiwan,N.;  Chakraborty,N.;  Chaverri,P.;  Cheewangkoon,R.;  Chen,C.;  Chen,C. Y.;  Chen,K. H.;  Chen,J.;  Chen,Q.;  Chen,W. H.;  Chen,Y. P.;  Chethana,K. W. T.;  Coleine,C.;  Conde,T. O.;  Corazon-Guivin,M. A.;  Cortes-Perez,A.;  Costa-Rezende,D. H.;  Courtecuisse,R.;  Crouch,J. A.;  Crous,P. W.;  Cui,B. K.;  Cui,Y. Y.;  da Silva,D. K. A.;  da Silva,G. A.;  da Silva,I. R.;  da Silva,R. M. F.;  da Silva Santos,A. C.;  Dai,D. Q.;  Dai,Y. C.;  Damm,U.;  Darmostuk,V;  Zoha,Daroodi;  Das,K.;  Das,K.;  Davoodian,N.;  Davydov,E. A.;  Dayarathne,M. C.;  Decock,C.;  de Groot,M. D.;  De Kesel,A.;  dela Cruz,T. E. E.;  De Lange,R.;  Delgado,G.;  Denchev,C. M.;  Denchev,T. T.;  de Oliveira,N. T.;  de Silva,N.,I;  de Souza,F. A.;  Dentinger,B.;  Devadatha,B.;  Dianese,J. C.;  Dima,B.;  Diniz,A. G.;  Dissanayake,A. J.;  Dissanayake,L. S.;  Dogan,H. H.;  Doilom,M.;  Dolatabadi,S.;  Dong,W.;  Dong,Z. Y.;  Dos Santos,L. A.;  Drechsler-Santos,E. R.;  Du,T. Y.;  Dubey,M. K.;  Dutta,A. K.;  Egidi,E.;  Elliott,T. F.;  Elshahed,M. S.;  Erdogdu,M.;  Ertz,D.;  Etayo,J.;  Evans,H. C.;  Fan,X. L.;  Fan,Y. G.;  Fedosova,A. G.;  Fell,J.;  Fernandes,I;  Firmino,A. L.;  Fiuza,P. O.;  Flakus,A.;  Fragoso de Souza,C. A.;  Frisvad,J. C.;  Fryar,S. C.;  Gabaldon,T.;  Gajanayake,A. J.;  Galindo,L. J.;  Gannibal,P. B.;  Garcia,D.;  Garcia-Sandoval,S. R.;  Garrido-Benavent,I;  Garzoli,L.;  Gautam,A. K.;  Ge,Z-W;  Gene,D. J.;  Gentekaki,E.;  Ghobad-Nejhad,M.;  Giachini,A. J.;  Gibertoni,T. B.;  Goes-Neto,A.;  Gomdola,D.;  Gomes de Farias,A. R.;  Gorjon,S. P.;  Goto,B. T.;  Granados-Montero,M. M.;  Griffith,G. W.;  Groenewald,J. Z.;  Groenewald,M.;  Grossart,H. P.;  Gueidan,C.;  Gunarathne,A.;  Gunaseelan,S.;  Gusmao,L. F. P.;  Gutierrez,A. C.;  Guzman-Davalos,L.;  Haelewaters,D.;  Halling,R.;  Han,Y. F.;  Hapuarachchi,K. K.;  Harder,C. B.;  Harrington,T. C.;  Hattori,T.;  He,M. Q.;  He,S.;  He,S. H.;  Healy,R.;  Herandez-Restrepo,M.;  Heredia,G.;  Hodge,K. T.;  Holgado-Rojas,M.;  Hongsanan,S.;  Horak,E.;  Hosoya,T.;  Houbraken,J.;  Huang,S. K.;  Huanraluek,N.;  Hur,J. S.;  Hurdeal,V. G.;  Hustad,V. P.;  Iotti,M.;  Iturriaga,T.;  Jafar,E.;  Janik,P.;  Jany,J. L.;  Jayalal,R. G. U.;  Jayasiri,S. C.;  Jayawardena,R. S.;  Jeewon,R.;  Jeronimo,G. H.;  Jesus,A. L.;  Jin,J.;  Johnston,P. R.;  Jones,E. B. G.;  Joshi,Y.;  Justo,A.;  Kaishian,P.;  Kakishima,M.;  Kaliyaperumal,M.;  Kang,G. P.;  Kang,J. C.;  Karakehian,J. M.;  Karimi,O.;  Karpov,S. A.;  Karunarathna,S. C.;  Kaufmann,M.;  Kemler,M.;  Kezo,K.;  Khyaju,S.;  Kirchmair,M.;  Kirk,P. M.;  Kitaura,M. J.;  Klawonn,I;  Kolarik,M.;  Kong,A.;  Kuhar,F.;  Kukwa,M.;  Kumar,S.;  Kusan,I;  Lado,C.;  Larsson,K. H.;  Latha,K. P. D.;  Lee,H. B.;  Leonardi,M.;  Leontyev,D. L.;  Lestari,A. S.;  Li,C. J. Y.;  Li,D. W.;  Li,H.;  Li,H. Y.;  Li,L.;  Li,Q. R.;  Li,Q.;  Li,W. L.;  Li,Y.;  Li,Y. C.;  Li,Y. X.;  Liao,C. F.;  Liimatainen,K.;  Lim,Y. W.;  Lin,C. G.;  Linaldeddu,B. T.;  Linde,C. C.;  Linn,M. M.;  Liu,F.;  Liu,J. K.;  Liu,N. G.;  Liu,S.;  Liu,S. L.;  Liu,X. F.;  Liu,X. Y.;  Liu,X. Z.;  Liu,Z. B.;  Lu,L.;  Lu,Y. Z.;  Luangharn,T.;  Luangsa-ard,J. J.;  Lumbsch,H. T.;  Lumyong,S.;  Luo,L.;  Luo,M.;  Luo,Z. L.;  Ma,J.;  Machado,A. R.;  Madagammana,A. D.;  Madrid,H.;  Magurno,F.;  Magyar,D.;  Mahadevan,N.;  Maharachchikumbura,S. S. N.;  Maimaiti,Y.;  Malosso,E.;  Manamgoda,D. S.;  Manawasinghe,I. S.;  Mapook,A.;  Marasinghe,D. S.;  Mardones,M.;  Marin-Felix,Y.;  Marquez,R.;  Masigol,H.;  Matocec,N.;  May,T. W.;  McKenzie,E. H. C.;  Meiras-Ottoni,A.;  Melo,R. F. R.;  Mendes-Alvarenga,R. L.;  Mendieta,S.;  Meng,Q. F.;  Menkis,A.;  Menolli,N.,Jr.;  Mesic,A.;  Meza Calvo,J. G.;  Mikhailov,K.,V;  Miller,S. L.;  Moncada,B.;  Moncalvo,J. M.;  Monteiro,J. S.;  Monteiro,M.;  Mora-Montes,H. M.;  Moreau,P. A.;  Mueller,G. M.;  Mukhopadyay,S.;  Murugadoss,R.;  Nagy,L. G.;  Najafiniya,M.;  Nanayakkara,C. M.;  Nascimento,C. C.;  Nei,Y.;  Neves,M. A.;  Neuhauser,S.;  Niego,A. G. T.;  Nilsson,R. H.;  Niskanen,T.;  Niveiro,N.;  Noorabadi,M. T.;  Noordeloos,M. E.;  Norphanphoun,C.;  Nunez Otano,N. B.;  O'Donnell,R. P.;  Oehl,F.;  Olariaga,I;  Orlando,O. P.;  Pang,K. L.;  Papp,V;  Pawlowska,J.;  Peintner,U.;  Pem,D.;  Pereira,O. L.;  Perera,R. H.;  Perez-Moreno,J.;  Perez-Ortega,S.;  Peter,G.;  Phillips,A. J. L.;  Phonemany,M.;  Phukhamsakda,C.;  Phutthacharoen,K.;  Piepenbring,M.;  Pires-Zottarelli,C. L. A.;  Poinar,G.;  Posta,A.;  Prieto,M.;  Promputtha,I;  Quandt,C. A.;  Radek,R.;  Rahnama,K.;  Raj,K. N. A.;  Rajeshkumar,K. C.;  Rama,T.;  Rambold,G.;  Ramirez-Cruz,V;  Rasconi,S.;  Rathnayaka,A. R.;  Raza,M.;  Ren,G. C.;  Robledo,G. L.;  Rodriguez-Flakus,P.;  Ronikier,A.;  Rossi,W.;  Ryberg,M.;  Ryvarden,L. R.;  Salvador-Montoya,C. A.;  Samant,B.;  Samarakoon,B. C.;  Samarakoon,M. C.;  Sanchez-Castro,I;  Sanchez-Garcia,M.;  Sandoval-Denis,M.;  Santamaria,B.;  Santiago,A. L. C. M. A.;  Sarma,V. V.;  Savchenko,A.;  Savchenko,K.;  Saxena,R. K.;  Scholler,M.;  Schoutteten,N.;  Seifollahi,E.;  Selbmann,L.;  Selcuk,F.;  Senanayake,I. C.;  Seto,K.;  Shabashova,T. G.;  Shen,H. W.;  Shen,Y. M.;  Silva-Filho,A. G. S.;  Simmons,D. R.;  Singh,R.;  Sir,E. B.;  Song,C. G.;  Souza-Motta,C. M.;  Sruthi,O. P.;  Stadler,M.;  Stchigel,A. M.;  Stemler,J.;  Stephenson,S. L.;  Strassert,J. F. H.;  Su,H. L.;  Su,L.;  Suetrong,S.;  Sulistyo,B.;  Sun,Y. F.;  Sun,Y. R.;  Svantesson,S.;  Sysouphanthong,P.;  Takamatsu,S.;  Tan,T. H.;  Tanaka,K.;  Tang,A. M. C.;  Tang,X.;  Tanney,J. B.;  Tavakol,N. M.;  Taylor,J. E.;  Taylor,P. W. J.;  Tedersoo,L.;  Tennakoon,D. S.;  Thamodini,G. K.;  Thines,M.;  Thiyagaraja,V;  Thongklang,N.;  Tiago,P.,V;  Tian,Q.;  Tian,W. H.;  Tibell,L.;  Tibell,S.;  Tibpromma,S.;  Tkalcec,Z.;  Tomsovsky,M.;  Toome-Heller,M.;  Torruella,G.;  Tsurykau,A.;  Udayanga,D.;  Ulukapi,M.;  Untereiner,W. A.;  Uzunov,B. A.;  Valle,L. G.;  Van Caenegem,W.;  Van den Wyngaert,S.;  Van Vooren,N.;  Velez,P.;  Verma,R. K.;  Vieira,L. C.;  Vieira,W. A. S.;  Vizzini,A.;  Walker,A.;  Walker,A. K.;  Wanasinghe,D. N.;  Wang,C. G.;  Wang,K.;  Wang,S. X.;  Wang,X. Y.;  Wang,Y.;  Wannasawang,N.;  Wartchow,F.;  Wei,D. P.;  Wei,X. L.;  White,J. F.;  Wijayawardene,N. N.;  Wijesinghe,S. N.;  Wijesundara,D. S. A.;  Wisitrassameewong,K.;  Worthy,F. R.;  Wu,F.;  Wu,G.;  Wu,H. X.;  Wu,N.;  Wu,W. P.;  Wurzbacher,C.;  Xiao,Y. P.;  Xiong,Y. R.;  Xu,B.;  Xu,L. J.;  Xu,R.;  Xu,R. F.;  Xu,R. J.;  Xu,T. M.;  Yakovchenko,L.;  Yan,J. Y.;  Yang,H. D.;  Yang,J.;  Yang,Z. L.;  Yang,Y. H.;  Yapa,N.;  Yasanthika,E.;  Youssef,N. H.;  Yu,F. M.;  Yu,Q.;  Yu,X. D.;  Yu,Y. X.;  Yu,Z. F.;  Yuan,H. S.;  Yuan,Y.;  Yurkov,A.;  Zafari,D.;  Zamora,J. C.;  Zare,R.;  Zeng,M.;  Zeng,N. K.;  Zeng,X. Y.;  Zhang,F.;  Zhang,H.;  Zhang,J. F.;  Zhang,J. Y.;  Zhang,Q. Y.;  Zhang,S. N.;  Zhang,W.;  Zhang,Y.;  Zhang,Y. X.;  Zhao,C. L.;  Zhao,H.;  Zhao,Q.;  Zhao,R. L.;  Zhou,L. W.;  Zhou,M.;  Zhurbenko,M. P.;  Zin,H. H.;  Zucconi,L.
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classification  nomenclature  scientific criticism  taxonomy  LEVEL PHYLOGENETIC CLASSIFICATION  INCORPORATING ANAMORPHIC FUNGI  FATTY-ACID-COMPOSITION  DNA-SEQUENCE DATA  NATURAL CLASSIFICATION  LEAF-LITTER  SPECIES RECOGNITION  IDENTIFICATION  NOMENCLATURE  TREE  
Discovery of ACE Inhibitory Peptides Derived from Green Coffee Using In Silico and In Vitro Methods 期刊论文
FOODS, 2023, 卷号: 12, 期号: 18, 页码: 3480
作者:  Dai,Haopeng;  He,Min;  Hu,Guilin;  Li,Zhongrong;  Al-Romaima,Abdulbaset;  Wu,Zhouwei;  Liu,Xiaocui;  Qiu,Minghua
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coffee protein  peptide  ACE inhibitor  LC-MS/MS  molecular docking  ANGIOTENSIN-CONVERTING ENZYME  IDENTIFICATION  
Fungalpedia, an illustrated compendium of the fungi and fungus-like taxa 期刊论文
MYCOSPHERE, 2023, 卷号: 14, 期号: 1, 页码: 1835-1959
作者:  Hyde,K. D.;  Amuhenage,T. B.;  Apurillo,C. C. S.;  Asghari,R.;  Aumentado,H. D.;  Bahkali,A. H.;  Bera,I;  Bhunjun,C. S.;  Calabon,M. S.;  Chandrasiri,S.;  Chethana,K. W. T.;  Doilom,M.;  Dong,W.;  Fallahi,M.;  Gajanayake,A. J.;  Gomdola,D.;  Gunarathne,A.;  Hongsanan,S.;  Huanraluek,N.;  Jayawardena,R. S.;  Kapov,S. A.;  Khyaju,S.;  Le,L.;  Li,C. J. Y.;  Li,Q. R.;  Li,Y. X.;  Lin,C. G.;  Linn,M. M.;  Liu,J. K.;  Liu,N. G.;  Luangharn,T.;  Madagammana,A. D.;  Manawasinghe,I. S.;  Marasinghe,D. S.;  McKenzie,E. H. C.;  Meakala,N.;  Meng,Q. F.;  Mukhopadhyay,S.;  Norphanphoun,C.;  Pem,D.;  Phukhamsakda,C.;  Sarma,V. V.;  Selcuk,F.;  Senanayake,I. C.;  Shah,S.;  Shu,Y. X.;  Silva,H. V. S.;  Su,H. L.;  Tavakol,M.;  Thakshila,S. A. D.;  Thiyagaraja,V;  Thongklang,N.;  Tian,Q.;  Tibpromma,S.;  Tun,Z. L.;  Ulukapi,M.;  Wang,Y.;  Wannasawang,N.;  Wijayawardene,N. N.;  Wimalasena,S. D. M. K.;  Xiao,Y.;  Xiong,Y. R.;  Yasanthika,W. A. E.;  Li,Q.;  Dai,D. Q.
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Achrochaeta  Agaricus  Alveariospora  Anastomitrabeculia  Aphelidiales  Ascagilis  Asterosporium  Applied mycology  Austropleospora  Basal fungi  Beltraniella  Blastocladiomyceta  Brunneofissura  Bryostigma  Borderline fungi  Castanedomyces  Chaetomella  Clitopaxillus  Coelomycetes  Colletotrichum  Coniella  Comoclathris  Conioscypha  Coprotaceae  Databases  Definitions  Dematiaceous hyphomycetes  Diaporthomycetidae  Dicephalospora  Discomycetes  Dothideomycetes  Epifoliar fungi  Eurotiomycetes  Eminent mycologists  Forest pathology  Freshwater fungi  degrees Fungicolous fungi  Fusarium  Fusasporis  Genera  Grass fungi  Halodiatrype  Higher taxa  Hypocreomycetidae  Hypomyces  Invertebrate fungi  Lichenicolous fungi  Juxtiphoma  Online database  Marine fungi  Megacoelomyces  Moheitospora  Mushrooms  Mycoprotein  Nematocenator  Naevia  Neoamphisphaeria  Obruspora  Oxydothis  Palm fungi  Palmiascoma  Pandanaceomyces  Parameliola  Pararoussoella  pileus  Pirozynskiomyces  Plant pathology  Pleopunctum  Polycephalomyces  Pseudoalternaria  Purpureocorticium  Quixadomyces  Salmacisia  Sanchytriomycota  Savitreea  Setoapiospora  Soil fungi  Sordariomycetidae  Synchaetomella  Towyspora  Wetland fungi  Willeya  Xylariomycetidae  Yeasts  FRESH-WATER FUNGI  POMEGRANATE PUNICA-GRANATUM  SP-NOV  PHYLOGENETIC-RELATIONSHIPS  MOLECULAR PHYLOGENY  1ST REPORT  SPECIES-DIVERSITY  REFINED FAMILIES  FAM.-NOV.  NATURAL CLASSIFICATION  
Species diversity of Hygrophorus in China and a phylogenetic study of the genus 期刊论文
MYCOSPHERE, 2023, 卷号: 14, 期号: 1, 页码: 1742-1834
作者:  Wang,C. Q.;  Zhang,M.;  He,X. L.;  Liu,J. W.;  Wei,T. Z.;  Liu,T. Z.;  Wang,K.;  Adamcik,S.;  Li,T. H.;  Deng,W. Q.
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Hygrophoraceae  Novel taxa  Phylogeny  Taxonomy  Waxcap  EDIBLE MUSHROOM  RUSSULA-COMPLEX  SEQUENCE DATA  SP. NOV.  AGARICALES  OLIVACEOUMBRINI  CLADES  
Oligosaccharide analysis of the backbone structure of the characteristic polysaccharide of Dendrobium officinale 期刊论文
FOOD HYDROCOLLOIDS, 2023, 卷号: 134, 页码: 108038
作者:  Wong, Tin-Long;  Li, Li-Feng;  Zhang, Ji-Xia;  Zhang, Quan-Wei;  Zhang, Xue-Ting;  Zhou, Li-Shuang;  Fung, Hau-Yee;  Feng, Lei;  Cheng, Hui -Yuan;  Huo, Chu-Ying;  Liu, Man;  Bao, Wan-Rong;  Wu, Wen-Jie;  Lai, Cheuk-Hei;  Bai, Su -Ping;  Nie, Shao-Ping;  Puno, Pema-Tenzin;  Lau, Clara Bik-San;  Leung, Ping -Chung;  Han, Quan-Bin;  Sun, Han-Dong
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Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities 期刊论文
MOLECULES, 2022, 卷号: 27, 期号: 5, 页码: 12
作者:  Luo, Han;  Qin, Wei;  Zhang, Hong;  Ren, Fu-Cai;  Fang, Wen-Tao;  Kong, Qing-Hua;  Yang, Liu;  Zhang, Jian-Mei;  Fang, Cheng-Wu;  Hu, Jiang-Miao;  Liu, Shou-Jin
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Rubia cordifolia  anthraquinones  NO inhibitory activity  antibacterial  
Engineering an oilseed crop for hyper-accumulation of carotenoids in the seeds without using a traditional marker gene 期刊论文
PLANT CELL REPORTS, 2022, 卷号: 41, 期号: 8, 页码: 1751-1761
作者:  He, Ming-Xia;  Wang, Jie-Lin;  Lin, Yuan-Yuan;  Huang, Jun-Chao;  Liu, Ai-Zhong;  Chen, Feng
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Camelina sativa  Carotenoid  beta-Carotene  Astaxanthin  Marker gene  9-CIS-EPOXYCAROTENOID DIOXYGENASE GENE  PHYTOENE SYNTHASE GENE  TRANSGENIC PLANTS  BETA-CAROTENE  KETOCAROTENOID BIOSYNTHESIS  CAMELINA-SATIVA  ASTAXANTHIN  CAULIFLOWER  OVEREXPRESSION  ARABIDOPSIS  
A new polysaccharide platform constructs self-adjuvant nanovaccines to enhance immune responses 期刊论文
JOURNAL OF NANOBIOTECHNOLOGY, 2022, 卷号: 20, 期号: 1, 页码: 320
作者:  Chen, Sisi;  Yang, Liu;  Ou, Xia;  Li, Jin-Yu;  Zi, Cheng-Ting;  Wang, Hao;  Hu, Jiang-Miao;  Liu, Ye
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Polysaccharide  Self-adjuvant  Nanovaccine  SARS-CoV-2  HIV  STRUCTURAL-CHARACTERIZATION  DENDRITIC CELLS  DRUG-DELIVERY  NANOPARTICLES  PARTICLES  CHITOSAN  GLYCOGEN  DESIGN  
Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities 期刊论文
MOLECULES, 2022, 卷号: 27, 期号: 5, 页码: 1730
作者:  Luo, Han;  Qin, Wei;  Zhang, Hong;  Ren, Fu-Cai;  Fang, Wen-Tao;  Kong, Qing-Hua;  Yang, Liu;  Zhang, Jian-Mei;  Fang, Cheng-Wu;  Hu, Jiang-Miao;  Liu, Shou-Jin
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Rubia cordifolia  anthraquinones  NO inhibitory activity  antibacterial  NITRIC-OXIDE  MEDICINAL-PLANT  CELL-CULTURES  L-ARGININE  CONSTITUENTS  BIOSYNTHESIS  DERIVATIVES  MECHANISMS  DISEASE