Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities

doi:10.3390/molecules27051730

	Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities
	Luo, Han 1; Qin, Wei 1; Zhang, Hong 1; Ren, Fu-Cai 2,3; Fang, Wen-Tao 1; Kong, Qing-Hua 2; Yang, Liu 2; Zhang, Jian-Mei 2; Fang, Cheng-Wu 1; Hu, Jiang-Miao2 ; Liu, Shou-Jin 1
Corresponding Author	Hu, Jiang-Miao(hujiangmiao@mail.kib.ac.cn) ; Liu, Shou-Jin(shjinliu@sina.com)
	2022-03-01
Source Publication	MOLECULES
Volume	27 Issue:5 Pages:12
Abstract	The present study aimed to identify the composition of the aerial parts of Rubia cordifolia L. A chemical investigation on the EtOAc extracts from the aerial parts of Rubia cordifolia resulted in the isolation of four new anthraquinones, namely Cordifoquinone A-D (1-4), along with 16 known anthraquinones. Their structures were elucidated on the basis of NMR and HR-ESIMS data. All isolates were assessed for their inhibitory effects on NO production in LPS-stimulated RAW264.7 macrophage cells. Compounds 1, 3 and 10 exhibited significant inhibitory activities with IC50 values of 14.05, 23.48 and 29.23 mu mol.L-1, respectively. Their antibacterial activities of four bacteria, Escherichia coli (ATCC 25922), Staphylococcus aureus subsp. aureus (ATCC 29213), Salmonella enterica subsp. enterica (ATCC 14028) and Pseudomonas aeruginosa (ATCC 27853), were also evaluated. Our results indicated that the antibacterial activity of these compounds is inactive.
Keyword	Rubia cordifolia anthraquinones NO inhibitory activity antibacterial
DOI	10.3390/molecules27051730
Indexed By	SCI ; SCI
Language	英语
WOS ID	WOS:000814406700001
Citation statistics	Cited Times:8[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73840
Collection	植物化学与西部植物资源持续利用国家重点实验室
Corresponding Author	Hu, Jiang-Miao; Liu, Shou-Jin
Affiliation	1.Anhui Univ Chinese Med, Coll Pharm, Hefei 230011, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Anhui Med Univ, Coll Pharm, Hefei 230011, Peoples R China
Recommended Citation GB/T 7714	Luo, Han,Qin, Wei,Zhang, Hong,et al. Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities[J]. MOLECULES,2022,27(5):12.
APA	Luo, Han.,Qin, Wei.,Zhang, Hong.,Ren, Fu-Cai.,Fang, Wen-Tao.,...&Liu, Shou-Jin.(2022).Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities.MOLECULES,27(5),12.
MLA	Luo, Han,et al."Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities".MOLECULES 27.5(2022):12.

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