Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities

doi:10.3390/molecules27051730

	Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities
	Luo, Han 1; Qin, Wei 1; Zhang, Hong 1; Ren, Fu-Cai 2,3; Fang, Wen-Tao 1; Kong, Qing-Hua 2; Yang, Liu 2; Zhang, Jian-Mei 2; Fang, Cheng-Wu 1; Hu, Jiang-Miao2 ; Liu, Shou-Jin 1
通讯作者	Hu, Jiang-Miao(hujiangmiao@mail.kib.ac.cn) ; Liu, Shou-Jin(shjinliu@sina.com)
	2022-03-01
发表期刊	MOLECULES
卷号	27 期号:5 页码:12
摘要	The present study aimed to identify the composition of the aerial parts of Rubia cordifolia L. A chemical investigation on the EtOAc extracts from the aerial parts of Rubia cordifolia resulted in the isolation of four new anthraquinones, namely Cordifoquinone A-D (1-4), along with 16 known anthraquinones. Their structures were elucidated on the basis of NMR and HR-ESIMS data. All isolates were assessed for their inhibitory effects on NO production in LPS-stimulated RAW264.7 macrophage cells. Compounds 1, 3 and 10 exhibited significant inhibitory activities with IC50 values of 14.05, 23.48 and 29.23 mu mol.L-1, respectively. Their antibacterial activities of four bacteria, Escherichia coli (ATCC 25922), Staphylococcus aureus subsp. aureus (ATCC 29213), Salmonella enterica subsp. enterica (ATCC 14028) and Pseudomonas aeruginosa (ATCC 27853), were also evaluated. Our results indicated that the antibacterial activity of these compounds is inactive.
关键词	Rubia cordifolia anthraquinones NO inhibitory activity antibacterial
DOI	10.3390/molecules27051730
收录类别	SCI ; SCI
语种	英语
WOS记录号	WOS:000814406700001
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73840
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Hu, Jiang-Miao; Liu, Shou-Jin
作者单位	1.Anhui Univ Chinese Med, Coll Pharm, Hefei 230011, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Anhui Med Univ, Coll Pharm, Hefei 230011, Peoples R China
推荐引用方式 GB/T 7714	Luo, Han,Qin, Wei,Zhang, Hong,et al. Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities[J]. MOLECULES,2022,27(5):12.
APA	Luo, Han.,Qin, Wei.,Zhang, Hong.,Ren, Fu-Cai.,Fang, Wen-Tao.,...&Liu, Shou-Jin.(2022).Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities.MOLECULES,27(5),12.
MLA	Luo, Han,et al."Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities".MOLECULES 27.5(2022):12.