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中国科学院昆明植物研究所知识管理系统
Knowledge Management System of Kunming Institute of Botany,CAS
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Oligosaccharide Blocks PAR1 (Proteinase-Activated Receptor 1)-PAR4-Mediated Platelet Activation by Binding to Thrombin Exosite II and Impairs Thrombosis
期刊论文
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2023, 卷号: 43, 期号: 2, 页码: 253-266
作者:
Li,Sujuan
;
Wang,Weili
;
Lin,Lisha
;
Yang,Lian
;
Cai,Ying
;
Yang,Xingzhi
;
Zhang,Taocui
;
Xiao,Chuang
;
Yan,Hui
;
Gao,Na
;
Zhao,Jinhua
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浏览/下载:85/16
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提交时间:2024/05/09
oligosaccharide
platelet activation
receptor
protease-activated
thrombin thrombosis
ANTIPLATELET THERAPIES
ALLOSTERIC LINKAGE
TISSUE FACTOR
PROTEASE
VORAPAXAR
MECHANISM
REVEALS
SITE
Structural Characterization and Anticoagulant Activities of a Keratan Sulfate-like Polysaccharide from the Sea Cucumber Holothuria fuscopunctata
期刊论文
MARINE DRUGS, 2023, 卷号: 21, 期号: 12, 页码: 632
作者:
Chen,Ru
;
Wang,Weili
;
Yin,Ronghua
;
Pan,Ying
;
Xu,Chen
;
Gao,Na
;
Luo,Xiaodong
;
Zhao,Jinhua
;
Reyes,Fernando
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Adobe PDF(6775Kb)
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浏览/下载:81/24
  |  
提交时间:2024/05/09
aminoglycan
structural features
keratan sulfate
depolymerization
oligosaccharides
anticoagulant activity
INTRINSIC-FACTOR XASE
GLYCOSAMINOGLYCAN
OLIGOSACCHARIDES
DEPOLYMERIZATION
ELUCIDATION
DERIVATIVES
HEPARIN
Structure characterization of a highly branched galactan from the slug Vaginulus alte and its utilization by human gut microbiota
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 卷号: 236, 页码: 123935
作者:
Zuo,Zhichuang
;
He,Zhicheng
;
Ma,Yan
;
Xu,Chen
;
Tao,Xuelin
;
Ning,Zimo
;
Gao,Li
;
Rehemiding,Ailainuer
;
Gao,Na
;
Zhao,Jinhua
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Adobe PDF(4459Kb)
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浏览/下载:48/6
  |  
提交时间:2024/07/30
Slug
Galactan
Chemical structure
Oligosaccharide
Human gut microbiota
SULFATED GALACTANS
HELIX-POMATIA
POLYSACCHARIDES
BIOACTIVITY
HYDROLYSIS
Structural Characterization and Heparanase Inhibitory Activity of Fucosylated Glycosaminoglycan from Holothuria floridana
期刊论文
MARINE DRUGS, 2021, 卷号: 19, 期号: 3, 页码: 162
作者:
Shi,Xiang
;
Guan,Ruowei
;
Zhou,Lutan
;
Zuo,Zhichuang
;
Tao,Xuelin
;
Wang,Pin
;
Zhou,Yanrong
;
Yin,Ronghua
;
Zhao,Longyan
;
Gao,Na
;
Zhao,Jinhua
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浏览/下载:178/0
  |  
提交时间:2022/04/02
Holothuria floridana
fucosylated glycosaminoglycans
oligosaccharide
chemical structure
heparanase
Five distinct fucan sulfates from sea cucumber Pattalus mollis: Purification, structural characterization and anticoagulant activities
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 卷号: 186, 页码: 535-543
作者:
Ma,Yan
;
Gao,Na
;
Zuo,Zhichuang
;
Li,Shanni
;
Zheng,Wenqi
;
Shi,Xiang
;
Liu,Qipei
;
Ma,Ting
;
Yin,Ronghua
;
Li,Xian
;
Zhao,Jinhua
收藏
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浏览/下载:133/0
  |  
提交时间:2022/04/02
Sea cucumber
Fucan sulfate
Chemical structure
Anticoagulant
Pattalus mollis
FUCOSYLATED GLYCOSAMINOGLYCAN
REPEATING UNIT
FUCOIDAN
POLYSACCHARIDES
ELUCIDATION
OLIGOSACCHARIDES
SPECTROSCOPY
Structural characterization of oligosaccharides from free radical depolymerized fucosylated glycosaminoglycan and suggested mechanism of depolymerization
期刊论文
CARBOHYDRATE POLYMERS, 2021, 卷号: 270, 页码: 118368
作者:
Chen,Ru
;
Yin,Ronghua
;
Li,Shanni
;
Pan,Ying
;
Mao,Hui
;
Cai,Ying
;
Lin,Lisha
;
Wang,Weili
;
Zhang,Taocui
;
Zhou,Lutan
;
Gao,Na
;
Luo,Xiaodong
;
Zhao,Jinhua
Adobe PDF(3356Kb)
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浏览/下载:141/36
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提交时间:2022/04/02
Fucosylated glycosaminoglycan
Free radical depolymerization
Chemical structure
Oligosaccharide
NMR
INTRINSIC TENASE COMPLEX
ANTICOAGULANT ACTIVITIES
SEA-CUCUMBER
CHONDROITIN SULFATE
PHYSICOCHEMICAL CHARACTERISTICS
FACTOR XASE
POLYSACCHARIDES
DERIVATIVES
HEPARIN
The Toxicology of Native Fucosylated Glycosaminoglycans and the Safety of Their Depolymerized Products as Anticoagulants
期刊论文
MARINE DRUGS, 2021, 卷号: 19, 期号: 9, 页码: 487
作者:
Lin,Lisha
;
Li,Sujuan
;
Gao,Na
;
Wang,Weili
;
Zhang,Taocui
;
Yang,Lian
;
Yang,Xingzhi
;
Luo,Dan
;
Ji,Xu
;
Zhao,Jinhua
Adobe PDF(2854Kb)
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  |  
浏览/下载:178/31
  |  
提交时间:2022/04/02
fucosylated glycosaminoglycan
anticoagulant
platelet aggregation
contact activation
hypotension
pulmonary embolism
CHONDROITIN SULFATE
CONTACT SYSTEM
COMPLEMENT
COAGULATION
ACTIVATION
ACCUMULATION
INVOLVEMENT
DERIVATIVES
KALLIKREIN
THROMBOSIS
Pharmacokinetics and Pharmacodynamics of a Depolymerized Glycosaminoglycan from Holothuria fuscopunctata, a Novel Anticoagulant Candidate, in Rats by Bioanalytical Methods
期刊论文
MARINE DRUGS, 2021, 卷号: 19, 期号: 4, 页码: 212
作者:
Liu,Shuang
;
Zhang,Taocui
;
Sun,Huifang
;
Lin,Lisha
;
Gao,Na
;
Wang,Weili
;
Li,Sujuan
;
Zhao,Jinhua
Adobe PDF(1230Kb)
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  |  
浏览/下载:258/61
  |  
提交时间:2022/04/02
pharmacokinetics
pharmacodynamics
anticoagulant
fucosylated glycosaminoglycan
dHG-5
method validation
High-molecular-weight fucosylated glycosaminoglycan induces human platelet aggregation depending on alpha(IIb)beta(3) and platelet secretion
期刊论文
PLATELETS, 2021, 卷号: 32, 期号: 7, 页码: 975-983
作者:
Lin,Lisha
;
Yang,Lian
;
Chen,Jun
;
Zhou,Lutan
;
Li,Sujuan
;
Gao,Na
;
Zhao,Jinhua
浏览
  |  
Adobe PDF(3733Kb)
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  |  
浏览/下载:118/31
  |  
提交时间:2022/04/02
Aggregation
fucosylated glycosaminoglycan
human platelets
secretion
alpha(IIb beta 3)
DEPOLYMERIZED HOLOTHURIAN GLYCOSAMINOGLYCAN
INTRINSIC TENASE COMPLEX
INTEGRIN ALPHA(IIB)BETA(3)
ACTIVATION
AGGLUTINATION
RECEPTOR
ADP
INHIBITION
GENERATION
MECHANISM
Oligosaccharides from fucosylated glycosaminoglycan prevent breast cancer metastasis in mice by inhibiting heparanase activity and angiogenesis
期刊论文
PHARMACOLOGICAL RESEARCH, 2021, 卷号: 166, 页码: 105527
作者:
Zhou,Lutan
;
Yin,Ronghua
;
Gao,Na
;
Sun,Huifang
;
Chen,Dingyuan
;
Cai,Ying
;
Ren,Lin
;
Yang,Lian
;
Zuo,Zhili
;
Zhang,Hongbin
;
Zhao,Jinhua
浏览
  |  
Adobe PDF(8336Kb)
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收藏
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浏览/下载:211/23
  |  
提交时间:2022/04/02
Oligosaccharides
Heparanase
Angiogenesis
Metastasis
FIBROBLAST-GROWTH-FACTOR
TUMOR-GROWTH
SULFATE PROTEOGLYCANS
MAMMALIAN HEPARANASE
COMBINATION
MECHANISMS
DISCOVERY
BINDING
TARGET
PI-88