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Phenanthridine Derivative Host Heat Shock Cognate 70 Down-Regulators as Porcine Epidemic Diarrhea Virus Inhibitors 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2021, 卷号: 84, 期号: 4, 页码: 1175-1184
作者:  Chen,Duo-Zhi;  Fan,Shi-Rui;  Yang,Bi-Juan;  Yao,Huo-Chun;  Wang,Yi-Ting;  Cai,Jie-Yun;  Jing,Chen-Xu;  Pan,Zi-Hao;  Luo,Miao;  Yuze,Yan-Qiu;  Liu,Guang-Jin;  Hao,Xiao-Jiang
浏览  |  Adobe PDF(8772Kb)  |  收藏  |  浏览/下载：88/20  |  提交时间：2022/04/02
PROTEIN  CORONAVIRUSES  SARS  PARTICLES  INSIGHTS  HSC70  
C30 and C31 Triterpenoids and Triterpene Sugar Esters with Cytotoxic Activities from Edible Mushroom Fomitopsis pinicola (Sw. Ex Fr.) Krast 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 卷号: 67, 期号: 37, 页码: 10330-10341
作者:  Peng, Xing-Rong;  Su, Hai-Guo;  Liu, Jun-Hong;  Huang, Yan-Jie;  Yang, Xin-Zhi;  Li, Zhong-Rong;  Zhou, Lin;  Qiu, Ming-Hua
浏览  |  Adobe PDF(1422Kb)  |  收藏  |  浏览/下载：193/60  |  提交时间：2019/11/07
Polyporaceae  Fomitopsis pinicola  C30 triterpenoids  C31 triterpenoids  cytotoxic activity  
A new actinomycin Z analogue with an additional oxygen bridge between chromophore and beta-depsipentapeptide from Streptomyces sp. KIB-H714 期刊论文
NATURAL PRODUCT RESEARCH, 2019, 卷号: 33, 期号: 2, 页码: 219-225
作者:  Dong, Miao;  Cao, Pei;  Ma, Ya-Tuan;  Luo, Jianying;  Yan, Yijun;  Li, Rong-Tao;  Huang, Sheng-Xiong
浏览  |  Adobe PDF(1106Kb)  |  收藏  |  浏览/下载：199/46  |  提交时间：2019/07/29
Actinomycin  Streptomyces  cytotoxicity  antibacterial activity  structure elucidation  
用于结构生物学研究的 ROR1胞外段 Fz 结构域的表达与纯化 学位论文
硕士, 2018
作者:  张滢滢
Adobe PDF(3815Kb)  |  收藏  |  浏览/下载：33/1  |  提交时间：2021/01/05
微酸多年卧孔菌等七种高等真菌化学成分研究 学位论文
: 中国科学院大学, 2016
作者:  文春南
Adobe PDF(8936Kb)  |  收藏  |  浏览/下载：119/7  |  提交时间：2018/08/23
Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors 期刊论文
ONCOTARGET, 2015, 卷号: 6, 期号: 33, 页码: 34953-34967
作者:  Liu,Yong-Qiang;  Wang,Xiao-Lu;  Cheng,Xin;  Lu,Yong-Zhi;  Wang,Gui-Zhen;  Li,Xin-Chun;  Zhang,Jian;  Wen,Zhe-Sheng;  Huang,Zhi-Liang;  Gao,Qin-Lei;  Yang,Li-Na;  Cheng,Yong-Xian;  Tao,Sheng-Ce;  Liu,Jinsong;  Zhou,Guang-Biao
浏览  |  Adobe PDF(2162Kb)  |  收藏  |  浏览/下载：271/64  |  提交时间：2016/01/19
Skp1  Lung Cancer  Structure-based High-throughput Virtual Screening  Inhibitors  6-o-angeloylplenolin  
The role of targeting kinase activity by natural products in cancer chemoprevention and chemotherapy (Review) 期刊论文
ONCOLOGY REPORTS, 2015, 卷号: 34, 期号: 2, 页码: 547-554
作者:  Luo, Xiangjian;  Yu, Xinfang;  Liu, Sufang;  Deng, Qipan;  Liu, Xiaolan;  Peng, Songling;  Li, Hongde;  Liu, Jikai;  Cao, Ya
浏览  |  Adobe PDF(755Kb)  |  收藏  |  浏览/下载：339/168  |  提交时间：2015/12/17
Natural Products  Grifolin  Neoalbaconol  Epigallocatechin-3-gallate  Cancer Prevention  
A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30 期刊论文
CELL RESEARCH, 2014, 卷号: 24, 期号: 4, 页码: 482-496
作者:  Yue, Wen;  Chen, Ziheng;  Liu, Haiyang;  Yan, Chen;  Chen, Ming;  Feng, Du;  Yan, Chaojun;  Wu, Hao;  Du, Lei;  Wang, Yueying;  Liu, Jinhua;  Huang, Xiaohu;  Xia, Laixin;  Liu, Lei;  Wang, Xiaohui;  Jin, Haijing;  Wang, Jun;  Song, Zhiyin;  Hao, Xiaojiang;  Chen, Quan
浏览  |  Adobe PDF(1659Kb)  |  收藏  |  浏览/下载：613/57  |  提交时间：2014/05/16
Mitochondrial Fusion  Mitofusin1/2  Deubiquitinase Usp30  15-oxospiramilactone  
Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer 期刊论文
BREAST CANCER RESEARCH, 2014, 卷号: 16, 期号: 4, 页码: 8220-8224
作者:  O'Leary, Patrick C.;  Terrile, Marta;  Bajor, Malgorzata;  Gaj, Pawel;  Hennessy, Bryan T.;  Mills, Gordon B.;  Zagozdzon, Agnieszka;  O'Connor, Darran P.;  Brennan, Donal J.;  Connor, Kate;  Li, Jane;  Gonzalez-Angulo, Ana Maria;  Sun, Han-Dong;  Pu, Jian-Xin;  Ponten, Fredrik;  Uhlen, Mathias;  Jirstrom, Karin;  Nowis, Dominika A.;  Crown, John P.;  Zagozdzon, Radoslaw;  Gallagher, William M.;  Zagozdzon,R (reprint author),UCD Sch Biomol & Biomed Sci,UCD Conway Inst,Canc Biol & Therapeut Lab,Dublin 4,Ireland.;  radoslaw.zagozdzon@wum.edu.pl;  william.gallagher@ucd.ie
浏览  |  Adobe PDF(2561Kb)  |  收藏  |  浏览/下载：184/59  |  提交时间：2015/01/20
Natural-products  Roots  Secretion  Norsesquiterpenoids  Norbisabolane  Pyrimidine  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
浏览  |  Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：255/43  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.