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C30 and C31 Triterpenoids and Triterpene Sugar Esters with Cytotoxic Activities from Edible Mushroom Fomitopsis pinicola (Sw. Ex Fr.) Krast 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 卷号: 67, 期号: 37, 页码: 10330-10341
Authors:  Peng, Xing-Rong;  Su, Hai-Guo;  Liu, Jun-Hong;  Huang, Yan-Jie;  Yang, Xin-Zhi;  Li, Zhong-Rong;  Zhou, Lin;  Qiu, Ming-Hua
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Polyporaceae  Fomitopsis pinicola  C30 triterpenoids  C31 triterpenoids  cytotoxic activity  
A new actinomycin Z analogue with an additional oxygen bridge between chromophore and beta-depsipentapeptide from Streptomyces sp. KIB-H714 期刊论文
NATURAL PRODUCT RESEARCH, 2019, 卷号: 33, 期号: 2, 页码: 219-225
Authors:  Dong, Miao;  Cao, Pei;  Ma, Ya-Tuan;  Luo, Jianying;  Yan, Yijun;  Li, Rong-Tao;  Huang, Sheng-Xiong
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Actinomycin  Streptomyces  cytotoxicity  antibacterial activity  structure elucidation  
Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors 期刊论文
ONCOTARGET, 2015, 卷号: 6, 期号: 33, 页码: 34953-34967
Authors:  Liu,Yong-Qiang;  Wang,Xiao-Lu;  Cheng,Xin;  Lu,Yong-Zhi;  Wang,Gui-Zhen;  Li,Xin-Chun;  Zhang,Jian;  Wen,Zhe-Sheng;  Huang,Zhi-Liang;  Gao,Qin-Lei;  Yang,Li-Na;  Cheng,Yong-Xian;  Tao,Sheng-Ce;  Liu,Jinsong;  Zhou,Guang-Biao
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Skp1  Lung Cancer  Structure-based High-throughput Virtual Screening  Inhibitors  6-o-angeloylplenolin  
The role of targeting kinase activity by natural products in cancer chemoprevention and chemotherapy (Review) 期刊论文
ONCOLOGY REPORTS, 2015, 卷号: 34, 期号: 2, 页码: 547-554
Authors:  Luo, Xiangjian;  Yu, Xinfang;  Liu, Sufang;  Deng, Qipan;  Liu, Xiaolan;  Peng, Songling;  Li, Hongde;  Liu, Jikai;  Cao, Ya
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Natural Products  Grifolin  Neoalbaconol  Epigallocatechin-3-gallate  Cancer Prevention  
A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30 期刊论文
CELL RESEARCH, 2014, 卷号: 24, 期号: 4, 页码: 482-496
Authors:  Yue, Wen;  Chen, Ziheng;  Liu, Haiyang;  Yan, Chen;  Chen, Ming;  Feng, Du;  Yan, Chaojun;  Wu, Hao;  Du, Lei;  Wang, Yueying;  Liu, Jinhua;  Huang, Xiaohu;  Xia, Laixin;  Liu, Lei;  Wang, Xiaohui;  Jin, Haijing;  Wang, Jun;  Song, Zhiyin;  Hao, Xiaojiang;  Chen, Quan
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Mitochondrial Fusion  Mitofusin1/2  Deubiquitinase Usp30  15-oxospiramilactone  
Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer 期刊论文
BREAST CANCER RESEARCH, 2014, 卷号: 16, 期号: 4, 页码: 8220-8224
Authors:  O'Leary, Patrick C.;  Terrile, Marta;  Bajor, Malgorzata;  Gaj, Pawel;  Hennessy, Bryan T.;  Mills, Gordon B.;  Zagozdzon, Agnieszka;  O'Connor, Darran P.;  Brennan, Donal J.;  Connor, Kate;  Li, Jane;  Gonzalez-Angulo, Ana Maria;  Sun, Han-Dong;  Pu, Jian-Xin;  Ponten, Fredrik;  Uhlen, Mathias;  Jirstrom, Karin;  Nowis, Dominika A.;  Crown, John P.;  Zagozdzon, Radoslaw;  Gallagher, William M.;  Zagozdzon,R (reprint author),UCD Sch Biomol & Biomed Sci,UCD Conway Inst,Canc Biol & Therapeut Lab,Dublin 4,Ireland.;  radoslaw.zagozdzon@wum.edu.pl;  william.gallagher@ucd.ie
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Natural-products  Roots  Secretion  Norsesquiterpenoids  Norbisabolane  Pyrimidine  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
Authors:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
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One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
Sugar is an endogenous cue for juvenile-to-adult phase transition in plants 期刊论文
ELIFE, 2013, 卷号: 2, 期号: 1, 页码: 00269
Authors:  Yu, Sha;  Cao, Li;  Zhou, Chuan-Miao;  Zhang, Tian-Qi;  Lian, Heng;  Sun, Yue;  Wu, Jianqiang;  Huang, Jirong;  Wang, Guodong;  Wang, Jia-Wei
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Arabidopsis-thaliana  Signal-transduction  Transcription  Micrornas  Serrate  Expression  Sucrose  Complex  Mir156  Gene  
Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus 期刊论文
NATURE IMMUNOLOGY, 2012, 卷号: 13, 期号: 5, 页码: 474-U73
Authors:  Federica Facciotti;  Gundimeda S Ramanjaneyulu;  Marco Lepore;  Sebastiano Sansano;  Marco Cavallari;  Magdalena Kistowska;  Sonja Forss-Petter;  Guanghui Ni;  Alessia Colone;  Amit Singhal;  Johannes Berger;  Chengfeng Xia;  Lucia Mori;  Gennaro De Libero
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Anticancer Drug  Garcinia Oligantha  Xanthone  Apoptosis  Caspase-3  Derivatives  Activation  
Plant-derived small molecule albaconol suppresses LPS-triggered proinflammatory cytokine production and antigen presentation of dendritic cells by impairing NF-kappa B activation 期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2008, 卷号: 8, 期号: 8, 页码: 1103-1111
Authors:  Liu, Qiuyan;  Shu, Xiaoli;  Sun, Anna;  Sun, Qiaoling;  Zhang, Chaoxiong;  An, Huazhang;  Liu, Jikai;  Cao, Xuetao
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Dendritic Cell  Immunosuppression  Inflammation  Cytokines  Nf-kappa b