| A new actinomycin Z analogue with an additional oxygen bridge between chromophore and beta-depsipentapeptide from Streptomyces sp. KIB-H714 | |
Dong, Miao1,2,3; Cao, Pei1,2; Ma, Ya-Tuan1,2; Luo, Jianying1,2 ; Yan, Yijun1,2; Li, Rong-Tao3; Huang, Sheng-Xiong1,2
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| 通讯作者 | Cao, Pei(sxhuang@mail.kib.ac.cn) ; Huang, Sheng-Xiong(caopei@wibe.ac.cn) |
| 2019-01-17 | |
| 发表期刊 | NATURAL PRODUCT RESEARCH
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| ISSN | 1478-6419 |
| 卷号 | 33期号:2页码:219-225 |
| 摘要 | Actinomycin Z(6) (1), a new member of the actinomycin family, along with three congeners of the Z-type (Z(1), Z(3), Z(5)) actinomycins, are produced from Streptomyces sp. KIB-H714. Their structures were authenticated by comprehensive spectroscopic data interpretation. Different from all the reported Z-type actinomycins, the beta-ring of the new compound actinomycin Z(6) includes an additional ring linked between the actinoyl chromophore and beta-peptidolactone. In Z(3) and Z(5), the L-threonine in beta-depsipeptide is replaced by the unusual 4-chlorothreonine, an amino acid rarely found in actinomycin family. All isolates were evaluated for cytotoxicity against five human tumor cell lines and for inhibitory activity against Candida albicans and Staphylococcus aureus. |
| 关键词 | Actinomycin Streptomyces cytotoxicity antibacterial activity structure elucidation |
| DOI | 10.1080/14786419.2018.1443097 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000462546400010 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/67680 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Cao, Pei; Huang, Sheng-Xiong |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming, Yunnan, Peoples R China 3.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Miao,Cao, Pei,Ma, Ya-Tuan,et al. A new actinomycin Z analogue with an additional oxygen bridge between chromophore and beta-depsipentapeptide from Streptomyces sp. KIB-H714[J]. NATURAL PRODUCT RESEARCH,2019,33(2):219-225. |
| APA | Dong, Miao.,Cao, Pei.,Ma, Ya-Tuan.,Luo, Jianying.,Yan, Yijun.,...&Huang, Sheng-Xiong.(2019).A new actinomycin Z analogue with an additional oxygen bridge between chromophore and beta-depsipentapeptide from Streptomyces sp. KIB-H714.NATURAL PRODUCT RESEARCH,33(2),219-225. |
| MLA | Dong, Miao,et al."A new actinomycin Z analogue with an additional oxygen bridge between chromophore and beta-depsipentapeptide from Streptomyces sp. KIB-H714".NATURAL PRODUCT RESEARCH 33.2(2019):219-225. |
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| dong2018.pdf（1106KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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