A new actinomycin Z analogue with an additional oxygen bridge between chromophore and beta-depsipentapeptide from Streptomyces sp. KIB-H714
Dong, Miao1,2,3; Cao, Pei1,2; Ma, Ya-Tuan1,2; Luo, Jianying1,2; Yan, Yijun1,2; Li, Rong-Tao3; Huang, Sheng-Xiong1,2
Corresponding AuthorCao, Pei(sxhuang@mail.kib.ac.cn) ; Huang, Sheng-Xiong(caopei@wibe.ac.cn)
2019-01-17
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
Volume33Issue:2Pages:219-225
AbstractActinomycin Z(6) (1), a new member of the actinomycin family, along with three congeners of the Z-type (Z(1), Z(3), Z(5)) actinomycins, are produced from Streptomyces sp. KIB-H714. Their structures were authenticated by comprehensive spectroscopic data interpretation. Different from all the reported Z-type actinomycins, the beta-ring of the new compound actinomycin Z(6) includes an additional ring linked between the actinoyl chromophore and beta-peptidolactone. In Z(3) and Z(5), the L-threonine in beta-depsipeptide is replaced by the unusual 4-chlorothreonine, an amino acid rarely found in actinomycin family. All isolates were evaluated for cytotoxicity against five human tumor cell lines and for inhibitory activity against Candida albicans and Staphylococcus aureus.
KeywordActinomycin Streptomyces cytotoxicity antibacterial activity structure elucidation
DOI10.1080/14786419.2018.1443097
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Applied ; Chemistry, Medicinal
WOS IDWOS:000462546400010
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/67680
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorCao, Pei; Huang, Sheng-Xiong
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming, Yunnan, Peoples R China
3.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Dong, Miao,Cao, Pei,Ma, Ya-Tuan,et al. A new actinomycin Z analogue with an additional oxygen bridge between chromophore and beta-depsipentapeptide from Streptomyces sp. KIB-H714[J]. NATURAL PRODUCT RESEARCH,2019,33(2):219-225.
APA Dong, Miao.,Cao, Pei.,Ma, Ya-Tuan.,Luo, Jianying.,Yan, Yijun.,...&Huang, Sheng-Xiong.(2019).A new actinomycin Z analogue with an additional oxygen bridge between chromophore and beta-depsipentapeptide from Streptomyces sp. KIB-H714.NATURAL PRODUCT RESEARCH,33(2),219-225.
MLA Dong, Miao,et al."A new actinomycin Z analogue with an additional oxygen bridge between chromophore and beta-depsipentapeptide from Streptomyces sp. KIB-H714".NATURAL PRODUCT RESEARCH 33.2(2019):219-225.
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