A new actinomycin Z analogue with an additional oxygen bridge between chromophore and beta-depsipentapeptide from Streptomyces sp. KIB-H714

doi:10.1080/14786419.2018.1443097

	A new actinomycin Z analogue with an additional oxygen bridge between chromophore and beta-depsipentapeptide from Streptomyces sp. KIB-H714
	Dong, Miao 1,2,3; Cao, Pei 1,2; Ma, Ya-Tuan 1,2; Luo, Jianying1,2 ; Yan, Yijun 1,2; Li, Rong-Tao 3; Huang, Sheng-Xiong1,2
通讯作者	Cao, Pei(sxhuang@mail.kib.ac.cn) ; Huang, Sheng-Xiong(caopei@wibe.ac.cn)
	2019-01-17
发表期刊	NATURAL PRODUCT RESEARCH
ISSN	1478-6419
卷号	33 期号:2 页码:219-225
摘要	Actinomycin Z(6) (1), a new member of the actinomycin family, along with three congeners of the Z-type (Z(1), Z(3), Z(5)) actinomycins, are produced from Streptomyces sp. KIB-H714. Their structures were authenticated by comprehensive spectroscopic data interpretation. Different from all the reported Z-type actinomycins, the beta-ring of the new compound actinomycin Z(6) includes an additional ring linked between the actinoyl chromophore and beta-peptidolactone. In Z(3) and Z(5), the L-threonine in beta-depsipeptide is replaced by the unusual 4-chlorothreonine, an amino acid rarely found in actinomycin family. All isolates were evaluated for cytotoxicity against five human tumor cell lines and for inhibitory activity against Candida albicans and Staphylococcus aureus.
关键词	Actinomycin Streptomyces cytotoxicity antibacterial activity structure elucidation
DOI	10.1080/14786419.2018.1443097
收录类别	SCI
语种	英语
WOS记录号	WOS:000462546400010
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/67680
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Cao, Pei; Huang, Sheng-Xiong
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming, Yunnan, Peoples R China 3.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Dong, Miao,Cao, Pei,Ma, Ya-Tuan,et al. A new actinomycin Z analogue with an additional oxygen bridge between chromophore and beta-depsipentapeptide from Streptomyces sp. KIB-H714[J]. NATURAL PRODUCT RESEARCH,2019,33(2):219-225.
APA	Dong, Miao.,Cao, Pei.,Ma, Ya-Tuan.,Luo, Jianying.,Yan, Yijun.,...&Huang, Sheng-Xiong.(2019).A new actinomycin Z analogue with an additional oxygen bridge between chromophore and beta-depsipentapeptide from Streptomyces sp. KIB-H714.NATURAL PRODUCT RESEARCH,33(2),219-225.
MLA	Dong, Miao,et al."A new actinomycin Z analogue with an additional oxygen bridge between chromophore and beta-depsipentapeptide from Streptomyces sp. KIB-H714".NATURAL PRODUCT RESEARCH 33.2(2019):219-225.

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