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C30 and C31 Triterpenoids and Triterpene Sugar Esters with Cytotoxic Activities from Edible Mushroom Fomitopsis pinicola (Sw. Ex Fr.) Krast
Peng, Xing-Rong1; Su, Hai-Guo1,2; Liu, Jun-Hong1,2; Huang, Yan-Jie1,2; Yang, Xin-Zhi1,2; Li, Zhong-Rong1; Zhou, Lin1; Qiu, Ming-Hua1
Corresponding AuthorQiu, Ming-Hua(mhchiu@mail.kib.ac.cn)
2019-09-18
Source PublicationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
Volume67Issue:37Pages:10330-10341
AbstractFomitopsis pinicola (Sw. Ex Fr.) Krast has been commonly used as a health food source and antitumor agent. To uncover bioactive key composition of F. pinicola, in our study, we investigated the chemical constituents of a methanol extract of F. pinicola and thirty-five lanostane-type tritetpenoids; 13 new compounds (1-13) and twenty-two known analogues (14-35) were isolated. Among them, compounds 1-9 were C30 lanostane triterpenoids and triterpene sugar esters, while compounds 10-13 were C31 triterpenoids and triterpene sugar esters. Their structures and absolute configurations were elucidated by extensive 1D, 2D NMR, MS, and IR spectra. Furthermore, cytotoxic activities of all isolates against five human tumor cell lines (HL-60, A549, SMMC-7721, MCF-7, and SW480) were evaluated. The results showed that compounds 12, 14, 17, 18, 22, and 23 displayed cytotoxic effects against five human tumor cell lines with IC50 values ranging from 3.92-28.51 mu M. Meanwhile, compounds 9 and 35 exhibited selected inhibitory activities against HL-60, SMMC-7721, and MCF-7 with IC50 values in the range of 13.57-36.01 mu M. Furthermore, the flow cytometry analysis revealed that compounds 17, 22, and 35 induced apoptosis in HL-60 cell lines. Their structure-activity relationships were preliminarily reported. These findings indicate the vital role of triterpenoids and their glycosides in explaining antitumor effects of F. pinicola and provide important evidence for further development and utilization of this fungus.
KeywordPolyporaceae Fomitopsis pinicola C30 triterpenoids C31 triterpenoids cytotoxic activity
DOI10.1021/acs.jafc.9b04530
Indexed BySCI
Language英语
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
WOS SubjectAgriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS IDWOS:000486362000006
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/69484
Collection中国科学院昆明植物研究所
Corresponding AuthorQiu, Ming-Hua
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Peng, Xing-Rong,Su, Hai-Guo,Liu, Jun-Hong,et al. C30 and C31 Triterpenoids and Triterpene Sugar Esters with Cytotoxic Activities from Edible Mushroom Fomitopsis pinicola (Sw. Ex Fr.) Krast[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019,67(37):10330-10341.
APA Peng, Xing-Rong.,Su, Hai-Guo.,Liu, Jun-Hong.,Huang, Yan-Jie.,Yang, Xin-Zhi.,...&Qiu, Ming-Hua.(2019).C30 and C31 Triterpenoids and Triterpene Sugar Esters with Cytotoxic Activities from Edible Mushroom Fomitopsis pinicola (Sw. Ex Fr.) Krast.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,67(37),10330-10341.
MLA Peng, Xing-Rong,et al."C30 and C31 Triterpenoids and Triterpene Sugar Esters with Cytotoxic Activities from Edible Mushroom Fomitopsis pinicola (Sw. Ex Fr.) Krast".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 67.37(2019):10330-10341.
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