Knowledge Management System of Kunming Institute of Botany,CAS
| C30 and C31 Triterpenoids and Triterpene Sugar Esters with Cytotoxic Activities from Edible Mushroom Fomitopsis pinicola (Sw. Ex Fr.) Krast | |
Peng, Xing-Rong1; Su, Hai-Guo1,2; Liu, Jun-Hong1,2; Huang, Yan-Jie1,2; Yang, Xin-Zhi1,2; Li, Zhong-Rong1; Zhou, Lin1; Qiu, Ming-Hua1
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| 通讯作者 | Qiu, Ming-Hua(mhchiu@mail.kib.ac.cn) |
| 2019-09-18 | |
| 发表期刊 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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| ISSN | 0021-8561 |
| 卷号 | 67期号:37页码:10330-10341 |
| 摘要 | Fomitopsis pinicola (Sw. Ex Fr.) Krast has been commonly used as a health food source and antitumor agent. To uncover bioactive key composition of F. pinicola, in our study, we investigated the chemical constituents of a methanol extract of F. pinicola and thirty-five lanostane-type tritetpenoids; 13 new compounds (1-13) and twenty-two known analogues (14-35) were isolated. Among them, compounds 1-9 were C30 lanostane triterpenoids and triterpene sugar esters, while compounds 10-13 were C31 triterpenoids and triterpene sugar esters. Their structures and absolute configurations were elucidated by extensive 1D, 2D NMR, MS, and IR spectra. Furthermore, cytotoxic activities of all isolates against five human tumor cell lines (HL-60, A549, SMMC-7721, MCF-7, and SW480) were evaluated. The results showed that compounds 12, 14, 17, 18, 22, and 23 displayed cytotoxic effects against five human tumor cell lines with IC50 values ranging from 3.92-28.51 mu M. Meanwhile, compounds 9 and 35 exhibited selected inhibitory activities against HL-60, SMMC-7721, and MCF-7 with IC50 values in the range of 13.57-36.01 mu M. Furthermore, the flow cytometry analysis revealed that compounds 17, 22, and 35 induced apoptosis in HL-60 cell lines. Their structure-activity relationships were preliminarily reported. These findings indicate the vital role of triterpenoids and their glycosides in explaining antitumor effects of F. pinicola and provide important evidence for further development and utilization of this fungus. |
| 关键词 | Polyporaceae Fomitopsis pinicola C30 triterpenoids C31 triterpenoids cytotoxic activity |
| DOI | 10.1021/acs.jafc.9b04530 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000486362000006 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/69484 |
| 专题 | 中国科学院昆明植物研究所 |
| 通讯作者 | Qiu, Ming-Hua |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Xing-Rong,Su, Hai-Guo,Liu, Jun-Hong,et al. C30 and C31 Triterpenoids and Triterpene Sugar Esters with Cytotoxic Activities from Edible Mushroom Fomitopsis pinicola (Sw. Ex Fr.) Krast[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019,67(37):10330-10341. |
| APA | Peng, Xing-Rong.,Su, Hai-Guo.,Liu, Jun-Hong.,Huang, Yan-Jie.,Yang, Xin-Zhi.,...&Qiu, Ming-Hua.(2019).C30 and C31 Triterpenoids and Triterpene Sugar Esters with Cytotoxic Activities from Edible Mushroom Fomitopsis pinicola (Sw. Ex Fr.) Krast.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,67(37),10330-10341. |
| MLA | Peng, Xing-Rong,et al."C30 and C31 Triterpenoids and Triterpene Sugar Esters with Cytotoxic Activities from Edible Mushroom Fomitopsis pinicola (Sw. Ex Fr.) Krast".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 67.37(2019):10330-10341. |
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