Phenanthridine Derivative Host Heat Shock Cognate 70 Down-Regulators as Porcine Epidemic Diarrhea Virus Inhibitors

doi:10.1021/acs.jnatprod.0c01252

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	Phenanthridine Derivative Host Heat Shock Cognate 70 Down-Regulators as Porcine Epidemic Diarrhea Virus Inhibitors
	Chen,Duo-Zhi ; Fan,Shi-Rui ; Yang,Bi-Juan ; Yao,Huo-Chun ; Wang,Yi-Ting ; Cai,Jie-Yun ; Jing,Chen-Xu ; Pan,Zi-Hao ; Luo,Miao ; Yuze,Yan-Qiu ; Liu,Guang-Jin ; Hao,Xiao-Jiang
	2021
Source Publication	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
Volume	84 Issue:4 Pages:1175-1184
Abstract	Porcine epidemic diarrhea virus (PEDV) has become increasingly problematic around the world, not only for its hazards to livestock but also due to the possibility that it is a zoonotic disease. Although vaccine therapy has made some progress toward PEDV control, additional effective therapeutic strategies against PEDV are needed, such as the development of chemotherapeutic agents. The aim of this work was to identify novel anti-PEDV agents by designing and synthesizing a series of phenanthridine derivatives. Among them, three compounds (compounds 1, 2, and 4) were identified as potent anti-PEDV agents exhibiting suppression of host cell heat shock cognate 70 (Hsc70) expression. Mechanism studies revealed that host Hsc70 is involved in the replication of PEDV, and its expression can be suppressed by destabilization of the mRNA, resulting in inhibition of PEDV replication. Activity against PEDV in vivo in PEDV-infected piglets suggested that phenanthridine derivatives are the first host-acting potential anti-PEDV agents.
Keyword	PROTEIN CORONAVIRUSES SARS PARTICLES INSIGHTS HSC70
DOI	10.1021/acs.jnatprod.0c01252
WOS ID	WOS:000644478400024
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73656
Collection	中国科学院昆明植物研究所
Affiliation	1.[Chen, Duo-Zhi 2.Fan, Shi-Rui 3.Yang, Bi-Juan 4.Wang, Yi-Ting 5.Cai, Jie-Yun 6.Jing, Chen-Xu 7.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 8.[Fan, Shi-Rui 9.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 10.[Yao, Huo-Chun 11.Pan, Zi-Hao 12.Luo, Miao 13.Yuze, Yan-Qiu 14.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China
Recommended Citation GB/T 7714	Chen,Duo-Zhi,Fan,Shi-Rui,Yang,Bi-Juan,et al. Phenanthridine Derivative Host Heat Shock Cognate 70 Down-Regulators as Porcine Epidemic Diarrhea Virus Inhibitors[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(4):1175-1184.
APA	Chen,Duo-Zhi.,Fan,Shi-Rui.,Yang,Bi-Juan.,Yao,Huo-Chun.,Wang,Yi-Ting.,...&Hao,Xiao-Jiang.(2021).Phenanthridine Derivative Host Heat Shock Cognate 70 Down-Regulators as Porcine Epidemic Diarrhea Virus Inhibitors.JOURNAL OF NATURAL PRODUCTS,84(4),1175-1184.
MLA	Chen,Duo-Zhi,et al."Phenanthridine Derivative Host Heat Shock Cognate 70 Down-Regulators as Porcine Epidemic Diarrhea Virus Inhibitors".JOURNAL OF NATURAL PRODUCTS 84.4(2021):1175-1184.

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