KIB OpenIR
Phenanthridine Derivative Host Heat Shock Cognate 70 Down-Regulators as Porcine Epidemic Diarrhea Virus Inhibitors
Chen,Duo-Zhi; Fan,Shi-Rui; Yang,Bi-Juan; Yao,Huo-Chun; Wang,Yi-Ting; Cai,Jie-Yun; Jing,Chen-Xu; Pan,Zi-Hao; Luo,Miao; Yuze,Yan-Qiu; Liu,Guang-Jin; Hao,Xiao-Jiang
2021
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume84Issue:4Pages:1175-1184
AbstractPorcine epidemic diarrhea virus (PEDV) has become increasingly problematic around the world, not only for its hazards to livestock but also due to the possibility that it is a zoonotic disease. Although vaccine therapy has made some progress toward PEDV control, additional effective therapeutic strategies against PEDV are needed, such as the development of chemotherapeutic agents. The aim of this work was to identify novel anti-PEDV agents by designing and synthesizing a series of phenanthridine derivatives. Among them, three compounds (compounds 1, 2, and 4) were identified as potent anti-PEDV agents exhibiting suppression of host cell heat shock cognate 70 (Hsc70) expression. Mechanism studies revealed that host Hsc70 is involved in the replication of PEDV, and its expression can be suppressed by destabilization of the mRNA, resulting in inhibition of PEDV replication. Activity against PEDV in vivo in PEDV-infected piglets suggested that phenanthridine derivatives are the first host-acting potential anti-PEDV agents.
KeywordPROTEIN CORONAVIRUSES SARS PARTICLES INSIGHTS HSC70
DOI10.1021/acs.jnatprod.0c01252
WOS IDWOS:000644478400024
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73656
Collection中国科学院昆明植物研究所
Affiliation1.[Chen, Duo-Zhi
2.Fan, Shi-Rui
3.Yang, Bi-Juan
4.Wang, Yi-Ting
5.Cai, Jie-Yun
6.Jing, Chen-Xu
7.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
8.[Fan, Shi-Rui
9.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
10.[Yao, Huo-Chun
11.Pan, Zi-Hao
12.Luo, Miao
13.Yuze, Yan-Qiu
14.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China
Recommended Citation
GB/T 7714
Chen,Duo-Zhi,Fan,Shi-Rui,Yang,Bi-Juan,et al. Phenanthridine Derivative Host Heat Shock Cognate 70 Down-Regulators as Porcine Epidemic Diarrhea Virus Inhibitors[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(4):1175-1184.
APA Chen,Duo-Zhi.,Fan,Shi-Rui.,Yang,Bi-Juan.,Yao,Huo-Chun.,Wang,Yi-Ting.,...&Hao,Xiao-Jiang.(2021).Phenanthridine Derivative Host Heat Shock Cognate 70 Down-Regulators as Porcine Epidemic Diarrhea Virus Inhibitors.JOURNAL OF NATURAL PRODUCTS,84(4),1175-1184.
MLA Chen,Duo-Zhi,et al."Phenanthridine Derivative Host Heat Shock Cognate 70 Down-Regulators as Porcine Epidemic Diarrhea Virus Inhibitors".JOURNAL OF NATURAL PRODUCTS 84.4(2021):1175-1184.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen,Duo-Zhi]'s Articles
[Fan,Shi-Rui]'s Articles
[Yang,Bi-Juan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen,Duo-Zhi]'s Articles
[Fan,Shi-Rui]'s Articles
[Yang,Bi-Juan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen,Duo-Zhi]'s Articles
[Fan,Shi-Rui]'s Articles
[Yang,Bi-Juan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.