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Design, Synthesis, and Anticancer Activity of Novel Trimethoxyphenyl-Derived Chalcone-Benzimidazolium Salts 期刊论文
ACS OMEGA, 2019, 卷号: 4, 期号: 23, 页码: 20381-20393
作者:  Yang, Jun-Li;  Ma, Yong-Hui;  Li, Yan-Hua;  Zhang, Yi-Peng;  Tian, Hong-Chang;  Huang, Yuan-Cheng;  Li, Yan;  Chen, Wen;  Yang, Li-Juan
浏览  |  Adobe PDF(2215Kb)  |  收藏  |  浏览/下载：213/50  |  提交时间：2020/03/18
B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells 期刊论文
ONCOGENE, 2019, 卷号: 38, 期号: 18, 页码: 3371-3386
作者:  Zhou, Hongyu;  Yu, Chunlei;  Kong, Lingmei;  Xu, Xiaoliang;  Yan, Juming;  Li, Yingchao;  An, Tao;  Gong, Liang;  Gong, Yaxiao;  Zhu, Huifang;  Zhang, Hongbin;  Yang, Xiaodong;  Li, Yan
浏览  |  Adobe PDF(5225Kb)  |  收藏  |  浏览/下载：237/27  |  提交时间：2019/06/24
Synthesis and cytotoxic activity of novel tetrahydrobenzodifuran-imidazolium salt derivatives 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 8, 页码: 1808-1814
作者:  Zhang, Chao-Bo;  Liu, Yang;  Liu, Zheng-Fen;  Duan, Sheng-Zu;  Li, Min-Yan;  Chen, Wen;  Li, Yan;  Zhang, Hong-Bin;  Yang, Xiao-Dong
浏览  |  Adobe PDF(1192Kb)  |  收藏  |  浏览/下载：625/105  |  提交时间：2017/06/30
Tetrahydrobenzodifurans  Imidazolium Salts  Cytotoxic Activity  Cell Cycle  Apoptosis  
RACK1 is required for adipogenesis 期刊论文
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2016, 卷号: 311, 期号: 5, 页码: C831-C836
作者:  Kong, Qinghua;  Gao, Lan;  Niu, Yanfen;  Gongpan, Pianchou;  Xu, Yuhui;  Li, Yan;  Xiong, Wenyong
浏览  |  Adobe PDF(1017Kb)  |  收藏  |  浏览/下载：302/43  |  提交时间：2017/02/14
Rack1  3t3-l1  Adipogenesis  Wnt  Pi3k-akt-mtor-s6k  
Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2016, 卷号: 116, 页码: 39-50
作者:  Zhou, Hongyu;  Shang, Chaowei;  Wang, Min;  Shen, Tao;  Kong, Lingmei;  Yu, Chunlei;  Ye, Zhennan;  Luo, Yan;  Liu, Lei;  Li, Yan;  Huang, Shile
浏览  |  Adobe PDF(3794Kb)  |  收藏  |  浏览/下载：175/36  |  提交时间：2017/01/05
Ciclopirox  Mtor  Ampk  Tsc2  Raptor  
N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells 期刊论文
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2016, 卷号: 35
作者:  Wang, Min;  Zhou, Ankun;  An, Tao;  Kong, Lingmei;  Yu, Chunlei;  Liu, Jianmei;  Xia, Chengfeng;  Zhou, Hongyu;  Li, Yan
浏览  |  Adobe PDF(1734Kb)  |  收藏  |  浏览/下载：195/30  |  提交时间：2016/06/27
N-hydroxyphthalimide  Mtor  Inhibitor  Cancer  Mitochondrial Apoptosis  
Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway 期刊论文
ONCOTARGET, 2014, 卷号: 5, 期号: 20, 页码: 10140-10150
作者:  Zhou, Hongyu;  Shen, Tao;  Shang, Chaowei;  Luo, Yan;  Liu, Lei;  Yan, Juming;  Li, Yan;  Huang, Shile
浏览  |  Adobe PDF(2703Kb)  |  收藏  |  浏览/下载：214/46  |  提交时间：2015/06/17
Ciclopirox  Autophagy  Rhabdomyosarcoma  Reactive Oxygen Species  Jnk  
Design, synthesis and antitumor activity of novel 8-substituted 2,3,5,6-tetrahydrobenzo[1,2-b:4, 5-b'] difuran imidazolium salt derivatives 期刊论文
RSC ADVANCES, 2014, 卷号: 4, 期号: 31, 页码: 16312-16319
作者:  Sun, Cheng-Jun;  Chen, Wen;  Li, Yan;  Liu, Lan-Xiang;  Wang, Xue-Quan;  Li, Li-Juan;  Zhang, Hong-Bin;  Yang, Xiao-Dong
浏览  |  Adobe PDF(997Kb)  |  收藏  |  浏览/下载：215/23  |  提交时间：2014/06/23
Hybrid Compounds  Cytotoxic Activities  Natural-products  Drug Discovery  Analogs  Dihydrobenzofuran  Cycloaddition  Benzofurans  Iodides  Trans  
Identification of two novel inhibitors of mTOR signaling pathway based on high content screening 期刊论文
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2013, 卷号: 72, 期号: 4, 页码: 799-808
作者:  Yan, Juming;  Zhou, Hongyu;  Kong, Lingmei;  Zhang, Jing;  Zhao, Qinshi;  Li, Yan
Adobe PDF(1971Kb)  |  收藏  |  浏览/下载：676/103  |  提交时间：2013/11/12
Mtor Signaling  Inhibitor  High Content Screening  Cancer  Apoptosis  
Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3-alkylbenzofuran and imidazole/triazole compounds 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 15, 页码: 4297-4302
作者:  Chen, Wen;  Deng, Xiao-Yan;  Li, Yan;  Yang, Li-Juan;  Wan, Wei-Chao;  Wang, Xue-Quan;  Zhang, Hong-Bin;  Yang, Xiao-Dong
浏览  |  Adobe PDF(820Kb)  |  收藏  |  浏览/下载：245/45  |  提交时间：2013/10/16
Hybrid Compound  Benzofuran  Imidazole  Triazole  Structure-activity Relationships