RACK1 is required for adipogenesis
Kong, Qinghua1; Gao, Lan1,2; Niu, Yanfen1,3; Gongpan, Pianchou1,2; Xu, Yuhui1,2; Li, Yan1,4; Xiong, Wenyong1,4
AbstractAdipose tissue plays a critical role in metabolic diseases and the maintenance of energy homeostasis. RACK1 has been identified as an adaptor protein involved in multiple intracellular signal transduction pathways and diseases. However, whether it regulates adipogenesis remains unknown. Here, we reported that RACK1 is expressed in 3T3-L1 cells and murine white adipose tissue and that RACK1 knockdown by shRNA profoundly suppressed adipogenesis by reducing the expression of PPAR-gamma and C/EBP-beta. Depletion of RACK1 increased beta-catenin protein levels and activated Wnt signaling. Furthermore, RACK1 knockdown also suppressed the PI3K-Akt-mTOR-S6K signaling pathway by reducing the PI3K p85 alpha, pAkt T473, and S6K p70. Taken together, these results demonstrate that RACK1 is a novel factor required for adipocyte differentiation by emerging Wnt/beta-catenin signaling and PI3K-Akt-mTOR-S6K signaling pathway(s).
KeywordRack1 3t3-l1 Adipogenesis Wnt Pi3k-akt-mtor-s6k
Indexed BySCI
WOS Research AreaCell Biology ; Physiology
WOS SubjectCell Biology ; Physiology
WOS IDWOS:000390107000013
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
3.Kunming Med Univ, Biomed Engn Res Ctr, Kunming, Peoples R China
4.Yunnan Key Lab Nat Med Chem, Kunming, Peoples R China
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GB/T 7714
Kong, Qinghua,Gao, Lan,Niu, Yanfen,et al. RACK1 is required for adipogenesis[J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY,2016,311(5):C831-C836.
APA Kong, Qinghua.,Gao, Lan.,Niu, Yanfen.,Gongpan, Pianchou.,Xu, Yuhui.,...&Xiong, Wenyong.(2016).RACK1 is required for adipogenesis.AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY,311(5),C831-C836.
MLA Kong, Qinghua,et al."RACK1 is required for adipogenesis".AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 311.5(2016):C831-C836.
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