| RACK1 is required for adipogenesis | |
Kong, Qinghua1; Gao, Lan1,2; Niu, Yanfen1,3; Gongpan, Pianchou1,2; Xu, Yuhui1,2; Li, Yan1,4 ; Xiong, Wenyong1,4
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| 2016-11-01 | |
| 发表期刊 | AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
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| 卷号 | 311期号:5页码:C831-C836 |
| 摘要 | Adipose tissue plays a critical role in metabolic diseases and the maintenance of energy homeostasis. RACK1 has been identified as an adaptor protein involved in multiple intracellular signal transduction pathways and diseases. However, whether it regulates adipogenesis remains unknown. Here, we reported that RACK1 is expressed in 3T3-L1 cells and murine white adipose tissue and that RACK1 knockdown by shRNA profoundly suppressed adipogenesis by reducing the expression of PPAR-gamma and C/EBP-beta. Depletion of RACK1 increased beta-catenin protein levels and activated Wnt signaling. Furthermore, RACK1 knockdown also suppressed the PI3K-Akt-mTOR-S6K signaling pathway by reducing the PI3K p85 alpha, pAkt T473, and S6K p70. Taken together, these results demonstrate that RACK1 is a novel factor required for adipocyte differentiation by emerging Wnt/beta-catenin signaling and PI3K-Akt-mTOR-S6K signaling pathway(s). |
| 关键词 | Rack1 3t3-l1 Adipogenesis Wnt Pi3k-akt-mtor-s6k |
| DOI | 10.1152/ajpcell.00224.2016 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000390107000013 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/33789 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 3.Kunming Med Univ, Biomed Engn Res Ctr, Kunming, Peoples R China 4.Yunnan Key Lab Nat Med Chem, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kong, Qinghua,Gao, Lan,Niu, Yanfen,et al. RACK1 is required for adipogenesis[J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY,2016,311(5):C831-C836. |
| APA | Kong, Qinghua.,Gao, Lan.,Niu, Yanfen.,Gongpan, Pianchou.,Xu, Yuhui.,...&Xiong, Wenyong.(2016).RACK1 is required for adipogenesis.AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY,311(5),C831-C836. |
| MLA | Kong, Qinghua,et al."RACK1 is required for adipogenesis".AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 311.5(2016):C831-C836. |
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| 49-RACK1 is required（1017KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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