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Total Synthesis of (-)-Geissoschizol through Ir-Catalyzed Allylic Amidation as the Key Step 期刊论文
ORGANIC LETTERS, 2017, 卷号: 19, 期号: 23, 页码: 6460-6462
作者:  Zheng, Yu;  Wei, Kun;  Yang, Yu-Rong
浏览  |  Adobe PDF(870Kb)  |  收藏  |  浏览/下载：168/55  |  提交时间：2018/05/08
Design, Synthesis, and Biological Activities of Vibsanin B Derivatives: A New Class of HSP90 C-Terminal Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 21, 页码: 9053-9066
作者:  Shao, Li-Dong;  Su, Jia;  Ye, Baixin;  Liu, Jiang-Xin;  Zuo, Zhi-Li;  Li, Yan;  Wang, Yue-Ying;  Xia, Chengfeng;  Zhao, Qin-Shi
浏览  |  Adobe PDF(5724Kb)  |  收藏  |  浏览/下载：391/43  |  提交时间：2017/12/18
Manginoids A-G: Seven Monoterpene-Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae 期刊论文
ORGANIC LETTERS, 2017, 卷号: 19, 期号: 21, 页码: 5956-5959
作者:  Chen, Keliang;  Zhang, Xuwen;  Sun, Weiguang;  Liu, Junjun;  Yang, Jing;  Chen, Chunmei;  Liu, Xiulan;  Gao, Limin;  Wang, Jianping;  Li, Hua;  Luo, Zengwei;  Xue, Yongbo;  Zhu, Hucheng;  Zhang, Yonghui
浏览  |  Adobe PDF(1771Kb)  |  收藏  |  浏览/下载：330/34  |  提交时间：2017/12/18
Old drug, new indication: Olsalazine sodium reduced serum uric acid levels in mice via inhibiting xanthine oxidoreductase activity 期刊论文
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2017, 卷号: 135, 期号: 3, 页码: 114-120
作者:  Niu, Yanfen;  Li, Hongjian;  Gao, Lihui;  Lin, Hua;  Kung, Hsiangfu;  Lin, Marie Chia-mi;  Leung, Kwong-Sak;  Wong, Man-Hon;  Xiong, Wenyong;  Li, Ling
收藏  |  浏览/下载：101/0  |  提交时间：2018/05/08
Olsalazine Sodium  Hyperuricemia  Xanthine Oxidase  Uric Acid  
Virtual screening of B-Raf kinase inhibitors: A combination of pharmacophore modelling, molecular docking, 3D-QSAR model and binding free energy calculation studies 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2017, 卷号: 70, 页码: 186-190
作者:  Zhang, Wen;  Qiu, Kai-Xiong;  Yu, Fang;  Xie, Xiao-Guang;  Zhang, Shu-Qun;  Chen, Ya-Juan;  Xie, Hui-Ding
浏览  |  Adobe PDF(371Kb)  |  收藏  |  浏览/下载：150/26  |  提交时间：2017/12/11
B-raf Kinase Inhibitors  Virtual Screening  Pharmacophore  Molecular Docking  3d Qsar  Binding Free Energy Calculation  
Potential role of CYP1B1 in the development and treatment of metabolic diseases 期刊论文
PHARMACOLOGY & THERAPEUTICS, 2017, 卷号: 178, 页码: 18-30
作者:  Li, Fei;  Zhu, Weifeng;  Gonzalez, Frank J.
浏览  |  Adobe PDF(2083Kb)  |  收藏  |  浏览/下载：187/61  |  提交时间：2017/11/20
Cyp1b1  Metabolic Diseases  Metabolic Pathways  Metabolomics  
Synthesis of selective 11 beta-HSD1 inhibitors based on dammarane scaffold 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 135, 页码: 324-338
作者:  Shao, Li-Dong;  Bao, Ying;  Shen, Yu;  Su, Jia;  Leng, Ying;  Zhao, Qin-Shi
浏览  |  Adobe PDF(1336Kb)  |  收藏  |  浏览/下载：318/74  |  提交时间：2017/07/31
11 Beta-hsd1 Inhibitor  Hupehenols  Dammarane  Sar  
The opioid receptor triple agonist DPI-125 produces analgesia with less respiratory depression and reduced abuse liability 期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 7, 页码: 977-989
作者:  Yi, Shou-pu;  Kong, Qing-hong;  Li, Yu-lei;  Pan, Chen-ling;  Yu, Jie;  Cui, Ben-qiang;  Wang, Ying-fei;  Wang, Guan-lin;  Zhou, Pei-lan;  Wang, Li-li;  Gong, Ze-hui;  Su, Rui-bin;  Shen, Yue-hai;  Yu, Gang;  Chang, Kwen-jen
浏览  |  Adobe PDF(854Kb)  |  收藏  |  浏览/下载：359/72  |  提交时间：2017/08/29
Opioid Receptor  Mixed Agonist  Dpi-125  Analgesia  Respiratory Depression  Addiction  
Asymmetric total synthesis of (-)-perforanoid A 期刊论文
TETRAHEDRON, 2017, 卷号: 73, 期号: 26, 页码: 3612-3621
作者:  Lv, Chao;  Tu, Qian;  Gong, Jianxian;  Hao, Xiaojiang;  Yang, Zhen
浏览  |  Adobe PDF(1315Kb)  |  收藏  |  浏览/下载：210/71  |  提交时间：2017/07/31
(-)-perforanoid a  Lemonoids  Asymmetric Total Synthesig  Rhodium Catalyzed  Intramolecular Pauson-khand  
Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production 期刊论文
MOLECULAR CARCINOGENESIS, 2017, 卷号: 56, 期号: 5, 页码: 1414-1426
作者:  Yu, Xinfang;  Li, Wei;  Deng, Qipan;  You, Shuo;  Liu, Haidan;  Peng, Songling;  Liu, Xiaolan;  Lu, Jingchen;  Luo, Xiangjian;  Yang, Lifang;  Tang, Min;  Weng, Xinxian;  Yi, Wei;  Liu, Wenbin;  Wu, Shengqi;  Ding, Zhihui;  Feng, Tao;  Zhou, Jian;  Fan, Jia;  Bode, Ann M.;  Dong, Zigang;  Liu, Jikai;  Cao, Ya
浏览  |  Adobe PDF(6365Kb)  |  收藏  |  浏览/下载：348/104  |  提交时间：2017/06/30
Angiogenesis  Breast Cancer  Egfr  Neoalbaconol  Vegf