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Quassinoids from Twigs of Harrisonia perforata (Blanco) Merr and Their Anti-Parkinson's Disease Effect 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 22, 页码: 16196
Authors:  Cai,Min;  Bai,Xiao-Lin;  Zang,Hao-Jing;  Tang,Xiao-Han;  Yan,Ying;  Wan,Jia-Jia;  Peng,Min-You;  Liang,Hong;  Liu,Lin;  Guo,Feng;  Zhao,Pei-Ji;  Liao,Xun;  Di,Ying-Tong;  Hao,Xiao-Jiang
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Harrisonia perforata  quassinoid  simarubaceae  neuroprotection  PC12 cells  PINK1(B9) flies  PROMISING BIOLOGICAL-ACTIVITY  UNPRECEDENTED QUASSINOIDS  
Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 2, 页码: 1088
Authors:  Yan,Ying;  Zhou,Qi;  Ran,Xiaoqian;  Lu,Qingyun;  Zhang,Cuishan;  Peng,Mingyou;  Tang,Lei;  Luo,Rongcan;  Di,Yingtong;  Hao,Xiaojiang
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euphjatrophane  Euphorbia peplus  jatrophane diterpenoid  autophagy  Tau pathology  UBIQUITIN-PROTEASOME SYSTEM  MULTIDRUG-RESISTANCE  BIOLOGICAL-ACTIVITY  ALZHEIMERS-DISEASE  MODULATORS  CELLS  
Phaeosphspirone (1/1 '), a pair of unique polyketide enantiomers with an unusual 6/5/5/6 tetracyclic ring from the desert plant endophytic fungus Phaeosphaeriaceae sp. 期刊论文
PHYTOCHEMISTRY, 2022, 卷号: 194, 页码: 112969
Authors:  Xu,Zhen-Lu;  Yan,Dao-Jiang;  Tan,Xiang-Mei;  Niu,Shu-Bin;  Yu,Meng;  Sun,Bing-Da;  Ding,Cai-Feng;  Zhang,Yong-Gang;  Ding,Gang
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Phaeosphspirone  Phaeosphaeriaceae  Absolute configurations  Biosynthetic pathway  Cytotoxicity  ASSISTED STRUCTURE ELUCIDATION  BIOSYNTHESIS  REVISION  
Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity 期刊论文
PHYTOCHEMISTRY, 2022, 卷号: 193, 页码: 112970
Authors:  Li,Ya-Nan;  Zeng,Yan-Rong;  Yang,Jue;  He,Wenwen;  Chen,Junlei;  Deng,Lulu;  Yi,Ping;  Huang,Lie-Jun;  Gu,Wei;  Hu,Zhan-Xing;  Yuan,Chun-Mao;  Hao,Xiao-Jiang
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Hypericum monogynum L.  Hypericaceae  Chemical constituents  Polycyclic polyprenylated acylphloroglucinols  Flavonoids  COX-2 inhibitors  
PXR mediates mifepristone-induced hepatomegaly in mice 期刊论文
ACTA PHARMACOLOGICA SINICA, 2022, 卷号: 43, 期号: 1, 页码: 146-156
Authors:  Yao,Xin-peng;  Jiao,Ting-ying;  Jiang,Yi-ming;  Fan,Shi-cheng;  Zhao,Ying-yuan;  Yang,Xiao;  Gao,Yue;  Li,Fei;  Zhou,Yan-ying;  Chen,Pan-pan;  Huang,Min;  Bi,Hui-chang
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mifepristone  hepatomegaly  pregnane X receptor (PXR)  yes-associated protein (YAP)  
Novel nucleocapsid protein-targeting phenanthridine inhibitors of SARS-CoV-2 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 227, 页码: 113966
Authors:  Wang,Yi-Ting;  Long,Xin-Yan;  Ding,Xiao;  Fan,Shi-Rui;  Cai,Jie-Yun;  Yang,Bi-Juan;  Zhang,Xin-Fang;  Luo,Rong-hua;  Yang,Lian;  Ruan,Ting;  Ren,Juan;  Jing,Chen-Xu;  Zheng,Yong-Tang;  Hao,Xiao-Jiang;  Chen,Duo-Zhi
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Phenanthridine  Nucleocapsid protein  SARS-CoV-2  N-terminal domain  N-TERMINAL DOMAIN  CORONAVIRUS  
A 2-oxoglutarate-dependent dioxygenase converts dihydrofuran to furan in Salvia diterpenoids 期刊论文
PLANT PHYSIOLOGY, 2022, 卷号: 188, 期号: 3, 页码: 1496-1506
Authors:  Song,Jiao-Jiao;  Fang,Xin;  Li,Chen-Yi;  Jiang,Yan;  Li,Jian-Xu;  Wu,Sheng;  Guo,Juan;  Liu,Yan;  Fan,Hang;  Huang,Yan-Bo;  Wei,Yu-Kun;  Kong,Yu;  Zhao,Qing;  Xu,Jing-Jing;  Hu,Yong-Hong;  Chen,Xiao-Ya;  Yang,Lei
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MOLECULAR-CLONING  BIOSYNTHESIS  TANSHINONES  EVOLUTION  CYTOTOXICITY  SUPERFAMILY  OXYGENASES  APOPTOSIS  SYNTHASE  
Three new jatrophane diterpenoids from Euphorbia peplus Linn. with activity towards autophagic flux 期刊论文
PHYTOCHEMISTRY LETTERS, 2022, 卷号: 50, 页码: 141-146
Authors:  Pu, Xue-Xue;  Ran, Xiao-Qian;  Yan, Ying;  Lu, Qing-Yun;  Li, Jin-Cun;  Li, Ying-Yao;  Guan, Shi-Peng;  Cao, Ming-Ming;  Liu, Jie;  Hao, Xiao-Jiang;  Luo, Rong-Can;  Di, Ying-Tong
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The Extracts of Dendrobium Alleviate Dry Eye Disease in Rat Model by Regulating Aquaporin Expression and MAPKs/NF-kappa B Signalling 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 卷号: 23, 期号: 19, 页码: 11195
Authors:  Ling, Jiawei;  Chan, Chung-Lap;  Ho, Chi-Yan;  Gao, Xun;  Tsang, Sin-Man;  Leung, Ping-Chung;  Hu, Jiang-Miao;  Wong, Chun-Kwok
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dry eye disease  Dendrobium  aquaporin  scopolamine  human cornea keratocytes  TNF-ALPHA  ACTIVATION  CLASSIFICATION  INFLAMMATION  DEFINITION  IL-1-BETA  APOPTOSIS  PATHWAYS  STRESS  MMP-9  
Catalytic innovation underlies independent recruitment of polyketide synthases in cocaine and hyoscyamine biosynthesis 期刊论文
NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 4994
Authors:  Tian, Tian;  Wang, Yong-Jiang;  Huang, Jian-Ping;  Li, Jie;  Xu, Bingyan;  Chen, Yin;  Wang, Li;  Yang, Jing;  Yan, Yijun;  Huang, Sheng-Xiong
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TROPANE ALKALOID BIOSYNTHESIS  CHAIN-LENGTH CONTROL