Pepluenone, a new pepluane-type diterpenoid with inhibitory activity on the release of NO from the whole plant of Euphorbia peplus L.

doi:10.1016/j.tetlet.2023.154550

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	Pepluenone, a new pepluane-type diterpenoid with inhibitory activity on the release of NO from the whole plant of Euphorbia peplus L.
	Huang,Jian-Yi; Yang,Ying; Liang,Hong; Pu,Xue-Xue; Li,Ying-Yao; Cai,Min; Guo,Feng; Liu,Lin; Cao,Ming-Ming; Yan,Ying; Cheng,Yuanyuan; Di,Ying-Tong; Hao,Xiao-Jiang
	2023
发表期刊	TETRAHEDRON LETTERS
ISSN	1873-3581
卷号	123 页码:154550
摘要	One new pepluane-type diterpenoid, pepluenone (1), and four known compounds were isolated from the whole plant of Euphorbia peplus L. Compound 1 possesses a 5/6/5/6 tetracyclic skeleton with a unique aromatic ring D. Its structure was determined based on spectroscopic data and X-ray crystallography. The biogenetic pathway of 1 was proposed, in which chemical transformation verified the aromatization step. In vitro anti-inflammatory activity tests indicated that Compounds 1 and 3 had a strong inhibitory effect on releasing NO from mouse macrophage RAW264.7 induced by LPS. & COPY; 2023 Elsevier Ltd. All rights reserved.
关键词	Anti-inflammatory Pepluane Diterpenoid Euphorbia peplus L Chemical transformation DISCOVERY PARALIANE INSIGHTS PROFILE LATEX
学科领域	Chemistry
DOI	10.1016/j.tetlet.2023.154550
收录类别	SCI
WOS记录号	WOS:001015176600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75412
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Huang,Jian-Yi,Yang,Ying,Liang,Hong,et al. Pepluenone, a new pepluane-type diterpenoid with inhibitory activity on the release of NO from the whole plant of Euphorbia peplus L.[J]. TETRAHEDRON LETTERS,2023,123:154550.
APA	Huang,Jian-Yi.,Yang,Ying.,Liang,Hong.,Pu,Xue-Xue.,Li,Ying-Yao.,...&Hao,Xiao-Jiang.(2023).Pepluenone, a new pepluane-type diterpenoid with inhibitory activity on the release of NO from the whole plant of Euphorbia peplus L..TETRAHEDRON LETTERS,123,154550.
MLA	Huang,Jian-Yi,et al."Pepluenone, a new pepluane-type diterpenoid with inhibitory activity on the release of NO from the whole plant of Euphorbia peplus L.".TETRAHEDRON LETTERS 123(2023):154550.

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