Quassinoids from Twigs of Harrisonia perforata (Blanco) Merr and Their Anti-Parkinson's Disease Effect

doi:10.3390/ijms242216196

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	Quassinoids from Twigs of Harrisonia perforata (Blanco) Merr and Their Anti-Parkinson's Disease Effect
	Cai,Min; Bai,Xiao-Lin; Zang,Hao-Jing; Tang,Xiao-Han; Yan,Ying; Wan,Jia-Jia; Peng,Min-You; Liang,Hong; Liu,Lin; Guo,Feng; Zhao,Pei-Ji; Liao,Xun; Di,Ying-Tong; Hao,Xiao-Jiang
	2023
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN	1422-0067
卷号	24 期号:22 页码:16196
摘要	Six new C-20 and one new C-19 quassinoids, named perforalactones F-L (1-7), were isolated from twigs of Harrisonia perforata. Spectroscopic and X-ray crystallographic experiments were conducted to identify their structures. Through oxidative degradation of perforalactone B to perforaqussin A, the biogenetic process from C-25 quassinoid to C-20 via Baeyer-Villiger oxidation was proposed. Furthermore, the study evaluated the anti-Parkinson's disease potential of these C-20 quassinoids for the first time on 6-OHDA-induced PC12 cells and a Drosophila Parkinson's disease model of PINK1(B9). Perforalactones G and I (2 and 4) showed a 10-15% increase in cell viability of the model cells at 50 mu M, while compounds 2 and 4 (100 mu M) significantly improved the climbing ability of PINK1(B9) flies and increased the dopamine level in the brains and ATP content in the thoraces of the flies.
关键词	Harrisonia perforata quassinoid simarubaceae neuroprotection PC12 cells PINK1(B9) flies PROMISING BIOLOGICAL-ACTIVITY UNPRECEDENTED QUASSINOIDS
DOI	10.3390/ijms242216196
WOS记录号	WOS:001114632500001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75018
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Cai,Min,Bai,Xiao-Lin,Zang,Hao-Jing,et al. Quassinoids from Twigs of Harrisonia perforata (Blanco) Merr and Their Anti-Parkinson's Disease Effect[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(22):16196.
APA	Cai,Min.,Bai,Xiao-Lin.,Zang,Hao-Jing.,Tang,Xiao-Han.,Yan,Ying.,...&Hao,Xiao-Jiang.(2023).Quassinoids from Twigs of Harrisonia perforata (Blanco) Merr and Their Anti-Parkinson's Disease Effect.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(22),16196.
MLA	Cai,Min,et al."Quassinoids from Twigs of Harrisonia perforata (Blanco) Merr and Their Anti-Parkinson's Disease Effect".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.22(2023):16196.

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