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Design, Synthesis, and Biological Evaluation of Novel Biotinylated Podophyllotoxin Derivatives as Potential Antitumor Agents 期刊论文
FRONTIERS IN CHEMISTRY, 2019, 卷号: 7, 页码: 14
作者:  Zi, Cheng-Ting;  Gao, Yin-Sheng;  Yang, Liu;  Feng, Shu-Yun;  Huang, Yue;  Sun, Li;  Jin, Yi;  Xu, Feng-Qing;  Dong, Fa-Wu;  Li, Yan;  Ding, Zhong-Tao;  Zhou, Jun;  Jiang, Zi-Hua;  Yuan, Sheng-Tao;  Hu, Jiang-Miao
Adobe PDF(1387Kb)  |  收藏  |  浏览/下载：250/58  |  提交时间：2019/07/29
podophyllotoxin derivatives  biotin  anticancer activity  synthesis  apoptosis  
B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells 期刊论文
ONCOGENE, 2019, 卷号: 38, 期号: 18, 页码: 3371-3386
作者:  Zhou, Hongyu;  Yu, Chunlei;  Kong, Lingmei;  Xu, Xiaoliang;  Yan, Juming;  Li, Yingchao;  An, Tao;  Gong, Liang;  Gong, Yaxiao;  Zhu, Huifang;  Zhang, Hongbin;  Yang, Xiaodong;  Li, Yan
Adobe PDF(5225Kb)  |  收藏  |  浏览/下载：235/27  |  提交时间：2019/06/24
Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2016, 卷号: 116, 页码: 39-50
作者:  Zhou, Hongyu;  Shang, Chaowei;  Wang, Min;  Shen, Tao;  Kong, Lingmei;  Yu, Chunlei;  Ye, Zhennan;  Luo, Yan;  Liu, Lei;  Li, Yan;  Huang, Shile
Adobe PDF(3794Kb)  |  收藏  |  浏览/下载：172/36  |  提交时间：2017/01/05
Ciclopirox  Mtor  Ampk  Tsc2  Raptor  
N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells 期刊论文
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2016, 卷号: 35
作者:  Wang, Min;  Zhou, Ankun;  An, Tao;  Kong, Lingmei;  Yu, Chunlei;  Liu, Jianmei;  Xia, Chengfeng;  Zhou, Hongyu;  Li, Yan
Adobe PDF(1734Kb)  |  收藏  |  浏览/下载：189/30  |  提交时间：2016/06/27
N-hydroxyphthalimide  Mtor  Inhibitor  Cancer  Mitochondrial Apoptosis  
The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of beta-Catenin 期刊论文
MOLECULAR AND CELLULAR BIOLOGY, 2014, 卷号: 34, 期号: 23, 页码: 4355-4366
作者:  Ma, Pengcheng;  Yang, Xiangcai;  Kong, Qinghua;  Li, Chaocui;  Yang, Shuangjuan;  Li, Yan;  Mao, Bingyu;  Mao,BY (reprint author),Kunming Inst Zool,State Key Lab Genet Resources & Evolut,Kunming,Peoples R China.;  mao@mail.kiz.ac.cn
浏览  |  Adobe PDF(1708Kb)  |  收藏  |  浏览/下载：271/54  |  提交时间：2015/01/20
Stem-cell Fate  Shoot Apical Meristem  Arabidopsis Shoot  Crabs-claw  Nectary Development  Expression  Thaliana  Family  Loop  Polarity  Iayabby2  Ad-abaxial Polarity  Incarvillea Arguta  Arabidopsis Thaliana  
Mangiferin and its aglycone, norathyriol, improve glucose metabolism by activation of AMP-activated protein kinase 期刊论文
PHARMACEUTICAL BIOLOGY, 2014, 卷号: 52, 期号: 1, 页码: 68-73
作者:  Wang, Fang;  Yan, Juming;  Niu, Yanfen;  Li, Yan;  Lin, Hua;  Liu, Xu;  Liu, Jikai;  Li, Ling
浏览  |  Adobe PDF(383Kb)  |  收藏  |  浏览/下载：281/59  |  提交时间：2014/04/09
Active Metabolite  Ampk  Insulin Resistance  L6 Muscle Cells  Norathyriol  
Identification of two novel inhibitors of mTOR signaling pathway based on high content screening 期刊论文
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2013, 卷号: 72, 期号: 4, 页码: 799-808
作者:  Yan, Juming;  Zhou, Hongyu;  Kong, Lingmei;  Zhang, Jing;  Zhao, Qinshi;  Li, Yan
Adobe PDF(1971Kb)  |  收藏  |  浏览/下载：673/102  |  提交时间：2013/11/12
Mtor Signaling  Inhibitor  High Content Screening  Cancer  Apoptosis  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
浏览  |  Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：247/43  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
The functional roles of lipid rafts in T-Cell activation, immune diseases and HIV infection and prevention 期刊论文
CELLULAR & MOLECULAR IMMUNOLOGY, 2008, 卷号: 5, 期号: 1, 页码: 1-7
作者:  Luo, Cheng;  Wang, Kou;  Liu, Dequan;  Li, Yan;  Zhao, Qinshi
Adobe PDF(909Kb)  |  收藏  |  浏览/下载：318/115  |  提交时间：2011/11/24
Lipid Raft  Liquid Ordered Phase  Liquid Crystal Phase  Cholesterol  Virus Assembly