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UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations Eph antagonist and angiogenesis 期刊论文
出版物, 3111, 期号: 0, 页码: 1-32
作者:  I Hassan-Mohamed;  C Giorgio;  M Incerti;  S Russo;  D Pala;  E B Pasquale;  P Vicini;  E Barocelli;  S Rivara;  M Mor;  A Lodola;  M Tognolini
Adobe PDF(1403Kb)  |  收藏  |  浏览/下载:452/1  |  提交时间:2017/07/24
Eph Kinase  Ephrin  Small Molecules  Angiogenesis  Bile Acid  Lithocholic Acid  
ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21 (CIP1/WAF1) in human cancer cells1 期刊论文
出版物, 3111, 期号: 0, 页码: 1-35
作者:  Jingru Li;  Yicheng Chen;  Jiali Wan;  Xin Liu;  Chunrong Yu;  Wenhua Li
Adobe PDF(1198Kb)  |  收藏  |  浏览/下载:367/1  |  提交时间:2017/07/24
Abt-263  Sorafenib  Combination Therapy  Cancer  
Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase-9 through modulation of NF-B and AP-1 activity in human liver cancer cells lines 期刊论文
出版物, 3111, 期号: 0, 页码: 1—28
作者:  Ming-Ju Hsieh;  Chiao-Wen Lin;  Shun-Fa Yang;  Mu-Kuan Chen;  Hui-Ling Chiou
Adobe PDF(1320Kb)  |  收藏  |  浏览/下载:417/1  |  提交时间:2017/07/24
Glabridin  Migration  Invasion  Matrix Metalloproteinase-9  Hepatoma  
YC-1 inhibits proliferation of breast cancer cells by downregulating EZH2 expression via activation of c-Cbl and ERK 期刊论文
出版物, 3111, 期号: 0, 页码: 1-46
作者:  Ling-Chu Chang;  Hui-Yi Lin;  Meng-Tung Tsai;  Ruey-Hwang Chou;  Fang-Yu Lee;  Che-Ming Teng;  Min-Tsang Hsieh;  Hsin-Yi Hung;  Li-Jiau Huang;  Yung-Luen Yu;  Sheng-Chu Kuo
Adobe PDF(1357Kb)  |  收藏  |  浏览/下载:513/1  |  提交时间:2017/07/24
Yc-1  Triple-negative Breast Cancer  Erk  Ezh2  C-cbl  
Design and synthesis of guaianolide-germacranolide heterodimers as novel anticancer agents against hepatocellular carcinoma 期刊论文
DRUG DEVELOPMENT RESEARCH, 2023
作者:  Yan,Jia-Xin;  Li,Qi-Hao;  Li,Tian-Ze;  Huang,Zhi-Yan;  Ma,Yun-Bao;  Chen,Ji-Jun
浏览  |  Adobe PDF(7663Kb)  |  收藏  |  浏览/下载:174/35  |  提交时间:2024/07/10
antihepatoma effects  guaianolide-germacranolide heterodimers  PDGFRA  DERIVATIVES  
Artemdubinoids A-N: novel sesquiterpenoids with antihepatoma cytotoxicity from Artemisia dubia 期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2023, 卷号: 21, 期号: 12, 页码: 902-915
作者:  Gao,Zhen;  Li,Tianze;  Ma,Yunbao;  Huang,Xiaoyan;  Geng,Changan;  Zhang,Xuemei;  Chen,Jijun
浏览  |  Adobe PDF(872Kb)  |  收藏  |  浏览/下载:172/31  |  提交时间:2024/07/22
Artemdubinoids A-N  Artemisia dubia  Sesquiterpenoids  Antihepatoma activity  
Design, synthesis, and biological evaluation of artemyrianolide H derivatives as potential antihepatoma agents 期刊论文
BIOORGANIC CHEMISTRY, 2023, 卷号: 137, 页码: 106617
作者:  Li,Tian-Ze;  Yang,Xiao-Tong;  Ma,Wen-Jing;  Ma,Yun-Bao;  Li,Feng-Jiao;  Wang,Yong-Cui;  Chen,Ji-Jun
浏览  |  Adobe PDF(9670Kb)  |  收藏  |  浏览/下载:192/47  |  提交时间:2024/07/22
Artemyrianolide H  Germacranolide derivatives  Antihepatoma activity  Apoptosis  DIMERS  
Prenylated acylphloroglucinols from the fruits of Garcinia xanthochymus 期刊论文
FITOTERAPIA, 2023, 卷号: 165, 页码: 105427
作者:  Xu,Zhi-Hong;  Luo,Yang;  Qiu,Yu-Feng;  Yang,Xing-Wei;  Lan,Tian
浏览  |  Adobe PDF(623Kb)  |  收藏  |  浏览/下载:146/24  |  提交时间:2024/07/25
Garcinia xanthochymus  Xanthochymusone  Structural determination  Cytotoxicity  PHLOROGLUCINOL DERIVATIVES  BENZOPHENONES  XANTHONES  
Sesquiterpenes from Carpesium faberi triggered ROS-induced apoptosis and protective autophagy in hepatocellular carcinoma cells 期刊论文
PHYTOCHEMISTRY, 2023, 卷号: 214, 页码: 113805
作者:  Yan,Ying;  Chen,Jie;  Peng,Mingyou;  Zhang,Xiong;  Feng,Enming;  Li,Qindan;  Guo,Bing;  Ding,Xiao;  Zhang,Yu;  Tang,Lei
浏览  |  Adobe PDF(4017Kb)  |  收藏  |  浏览/下载:156/42  |  提交时间:2024/07/25
Carpesium faberi (compositae)  Sesquiterpenes  Structural elucidation  Cytotoxic activities  Autophagy  LACTONE DIMERS  MYRRHANONE C  XANTHANOLIDES  TRITERPENE  HYBRIDS  ESTERS  
RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells 期刊论文
JOURNAL OF TRANSLATIONAL MEDICINE, 2023, 卷号: 21, 期号: 1, 页码: 886
作者:  Chen,Yuanzhi;  He,Zhicheng;  Yang,Shuting;  Chen,Cheng;  Xiong,Wenyong;  He,Yingying;  Liu,Shubai
浏览  |  Adobe PDF(4466Kb)  |  收藏  |  浏览/下载:189/39  |  提交时间:2024/05/09
Runt-related transcription factor 1 (RUNX1)  High-grade serous ovarian carcinoma (HGSOC)  Apoptosis  EMT  Clinical therapeutic target  EPITHELIAL-MESENCHYMAL TRANSITIONS  HEPATOCELLULAR-CARCINOMA  TRANSCRIPTION FACTOR  TP53 MUTATIONS  UP-REGULATION  TUMOR-GROWTH  MIGRATION  PROLIFERATION  INVASION  FOXO1