RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells

doi:10.1186/s12967-023-04762-8

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	RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells
	Chen,Yuanzhi; He,Zhicheng; Yang,Shuting; Chen,Cheng; Xiong,Wenyong; He,Yingying; Liu,Shubai
	2023
发表期刊	JOURNAL OF TRANSLATIONAL MEDICINE
ISSN	1479-5876
卷号	21 期号:1 页码:886
摘要	Ovarian cancer is the leading cause of death from gynecologic illnesses worldwide. High-grade serous ovarian cancer (HGSOC) is a gynecological tumor that accounts for roughly 70% of ovarian cancer deaths in women. Runt-related transcription factor 1(RUNX1) proteins were identified with overexpression in the HGSOC. However, the roles of RUNX1 in the development of HGSOC are poorly understood. In this study, combined with whole-transcriptome analysis and multiple research methods, RUNX1 was identified as vital in developing HGSOC. RUNX1 knockdown inhibits the physiological function of ovarian cancer cells and regulates apoptosis through the FOXO1-Bcl2 axis. Down-regulated RUNX1 impairs EMT function through the EGFR-AKT-STAT3 axis signaling. In addition, RUNX1 knockdown can significantly increase the sensitivity to clinical drug therapy for ovarian cancer. It is strongly suggested that RUNX1 work as a potential diagnostic and therapeutic target for HGSOC patients with better prognoses and treatment options. It is possible to generate novel potential targeted therapy strategies and translational applications for serous ovarian carcinoma patients with better clinical outcomes.
关键词	Runt-related transcription factor 1 (RUNX1) High-grade serous ovarian carcinoma (HGSOC) Apoptosis EMT Clinical therapeutic target EPITHELIAL-MESENCHYMAL TRANSITIONS HEPATOCELLULAR-CARCINOMA TRANSCRIPTION FACTOR TP53 MUTATIONS UP-REGULATION TUMOR-GROWTH MIGRATION PROLIFERATION INVASION FOXO1
DOI	10.1186/s12967-023-04762-8
WOS记录号	WOS:001115412200006
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74955
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Chen,Yuanzhi,He,Zhicheng,Yang,Shuting,et al. RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells[J]. JOURNAL OF TRANSLATIONAL MEDICINE,2023,21(1):886.
APA	Chen,Yuanzhi.,He,Zhicheng.,Yang,Shuting.,Chen,Cheng.,Xiong,Wenyong.,...&Liu,Shubai.(2023).RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells.JOURNAL OF TRANSLATIONAL MEDICINE,21(1),886.
MLA	Chen,Yuanzhi,et al."RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells".JOURNAL OF TRANSLATIONAL MEDICINE 21.1(2023):886.

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