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An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 105317
作者:  Munikishore,Rachakunta;  Wang,Liang-Liang;  Zhang,Shuqun;  Zhao,Qin-Shi;  Zuo,Zhili
Adobe PDF(523Kb)  |  收藏  |  浏览/下载：84/21  |  提交时间：2022/04/02
Cathepsin L  small-molecule inhibitor  gram-scale synthesis  KGP94  cancer  FUNCTIONALIZED BENZOPHENONE  BIOLOGICAL EVALUATION  TUMOR PROGRESSION  CELL INVASION  EXPRESSION  ANALOGS  SUPPRESSION  DERIVATIVES  ACID  
Oligosaccharides from fucosylated glycosaminoglycan prevent breast cancer metastasis in mice by inhibiting heparanase activity and angiogenesis 期刊论文
PHARMACOLOGICAL RESEARCH, 2021, 卷号: 166, 页码: 105527
作者:  Zhou,Lutan;  Yin,Ronghua;  Gao,Na;  Sun,Huifang;  Chen,Dingyuan;  Cai,Ying;  Ren,Lin;  Yang,Lian;  Zuo,Zhili;  Zhang,Hongbin;  Zhao,Jinhua
浏览  |  Adobe PDF(8336Kb)  |  收藏  |  浏览/下载：124/12  |  提交时间：2022/04/02
Oligosaccharides  Heparanase  Angiogenesis  Metastasis  FIBROBLAST-GROWTH-FACTOR  TUMOR-GROWTH  SULFATE PROTEOGLYCANS  MAMMALIAN HEPARANASE  COMBINATION  MECHANISMS  DISCOVERY  BINDING  TARGET  PI-88  
Identification of Novel TRPC5 Inhibitors by Pharmacophore-Based and Structure-Based Approaches 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2020
作者:  Li, Shuxiang;  Zhang, Shuqun;  Chen, Dingyuan;  Jiang, Xuan;  Liu, Bin;  Zhang, Hongbin;  Rachakunta, Munikishore;  Zuo, Zhili
浏览  |  Adobe PDF(4261Kb)  |  收藏  |  浏览/下载：152/39  |  提交时间：2021/01/05
Identification of potential AMPK activator by pharmacophore modeling, molecular docking and QSAR study 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019, 卷号: 79, 页码: 165-176
作者:  Li, Yingying;  Peng, Jiale;  Li, Penghua;  Du, Haibo;  Li, Yaping;  Liu, Xingyong;  Zhang, Li;  Wang, Liang-Liang;  Zuo, Zhili
浏览  |  Adobe PDF(7335Kb)  |  收藏  |  浏览/下载：252/28  |  提交时间：2019/07/29
Pharmacophore modeling  Molecular docking  Quantitative structure activity relationship (QSAR)  Molecular dynamics  AMPK  Activator  
Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 50, 页码: 82820-82835
作者:  Zhou, Xunian;  Yue, Grace Gar-Lee;  Liu, Minghua;  Zuo, Zhili;  Lee, Julia Kin-Ming;  Li, Mingyue;  Tsui, Stephen Kwok-Wing;  Fung, Kwok-Pui;  Sun, Handong;  Pu, Jianxin;  Lau, Clara Bik-San
浏览  |  Adobe PDF(13632Kb)  |  收藏  |  浏览/下载：321/34  |  提交时间：2017/02/28
Eriocalyxin b  Angiogenesis  Vascular Endothelial Growth Factor (Vegf)  Vascular Endothelial Growth Factor Receptor 2(Vegfr-2)  Breast Cancer  
Lingzhilactones from Ganoderma lingzhi ameliorate adriamycin-induced nephropathy in mice 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2015, 卷号: 176, 页码: 385-393
作者:  Yan, Yong-Ming;  Wang, Xin-Long;  Zhou, Li-Li;  Zhou, Feng-Jiao;  Li, Rong;  Tian, Yuan;  Zuo, Zhi-Li;  Fang, Ping;  Chung, Arthur C. K.;  Hou, Fan-Fan;  Cheng, Yong-Xian
浏览  |  Adobe PDF(8566Kb)  |  收藏  |  浏览/下载：653/73  |  提交时间：2016/02/01
Ganoderma Lingzhi  Ganodermataceae  Meroterpenoids  Chronic Kidney Disease  Reactive Oxygen Species  Nrf2  
Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation 期刊论文
PHYTOCHEMISTRY, 2015, 卷号: 114, 期号: SI, 页码: 155-162
作者:  Yan, Yong-Ming;  Wang, Xin-Long;  Luo, Qi;  Jiang, Li-Ping;  Yang, Cui-Ping;  Hou, Bo;  Zuo, Zhi-Li;  Chen, Yong-Bin;  Cheng, Yong-Xian;  Chen,YB (reprint author),132 Lanhei Rd,Kunming 650201,Peoples R China.;  ybchen@mail.kiz.ac.cn;  yxcheng@mail.kib.ac.cn
浏览  |  Adobe PDF(1019Kb)  |  收藏  |  浏览/下载：405/131  |  提交时间：2015/07/20
Ganoderma Lingzhi  Ganodermataceae  Meroterpenoids  Neural Stem Cells  Neurodegenerative Diseases  
Identification and validation of p50 as the cellular target of eriocalyxin B 期刊论文
ONCOTARGET, 2014, 卷号: 5, 期号: 22, 页码: 11354-11364
作者:  Kong, Ling-Mei;  Deng, Xu;  Zuo, Zhi-Li;  Sun, Han-Dong;  Zhao, Qin-Shi;  Li, Yan
浏览  |  Adobe PDF(3014Kb)  |  收藏  |  浏览/下载：298/78  |  提交时间：2015/06/17
Erib  Activity-based Probes  P50  Nf-kappa b Signaling  Apoptosis  
(+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3 期刊论文
ORGANIC LETTERS, 2014, 卷号: 16, 期号: 2, 页码: 532-535
作者:  Yan, Yong-Ming;  Ai, Jun;  Shi, Yan-Ni;  Zuo, Zhi-Li;  Hou, Bo;  Luo, Jie;  Cheng, Yong-Xian
Adobe PDF(229Kb)  |  收藏  |  浏览/下载：456/79  |  提交时间：2014/04/09
Disease  Products