Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation
Yan, Yong-Ming1,4; Wang, Xin-Long1,3; Luo, Qi1,4; Jiang, Li-Ping4,5; Yang, Cui-Ping5; Hou, Bo1; Zuo, Zhi-Li1; Chen, Yong-Bin5; Cheng, Yong-Xian1,2; Chen,YB (reprint author),132 Lanhei Rd,Kunming 650201,Peoples R China.; ybchen@mail.kiz.ac.cn; yxcheng@mail.kib.ac.cn
2015-06-01
Source PublicationPHYTOCHEMISTRY
Volume114Issue:SIPages:155-162
AbstractGanoderma lingzhi is a valuable, edible and medicinal fungus that has been widely used for the prevention and treatment of a broad range of diseases. In this study, spirolingzhines A-D, four meroterpenoids with a spiro[benzofuran-2,1'-cyclopentanel motif, lingzhines A-F, six meroterpenoids with diverse ring systems, along with two known compounds were isolated from the fruiting bodies of this fungus. The structures and stereochemistry of these substances were determined by using spectroscopic, X-ray crystallographic and computational methods. Chiral HPLC was used to separate (-)- and (+)-antipodes of seven of ten meroterpenoids, which were isolated from the fungus as racemic mixtures. Several of the metabolites were found to promote proliferation of neural stem cells (NSCs) and, as such, they constitute a class of NSC stimulators. The most potent member of this series, (-)-spirolingzhine A, was shown to affect NSC cell cycle progression using the 5-bromo-2-deoxyuridine (BrdU) incorporation assay. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordGanoderma Lingzhi Ganodermataceae Meroterpenoids Neural Stem Cells Neurodegenerative Diseases
Subject AreaBiochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytochem.2015.03.013
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000356551800014
Citation statistics
Cited Times:39[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/21332
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorChen,YB (reprint author),132 Lanhei Rd,Kunming 650201,Peoples R China.; ybchen@mail.kiz.ac.cn; yxcheng@mail.kib.ac.cn
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China
3.Henan Univ Tradit Chinese Med, Coll Pharm, Zhengzhou 450008, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
Recommended Citation
GB/T 7714
Yan, Yong-Ming,Wang, Xin-Long,Luo, Qi,et al. Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation[J]. PHYTOCHEMISTRY,2015,114(SI):155-162.
APA Yan, Yong-Ming.,Wang, Xin-Long.,Luo, Qi.,Jiang, Li-Ping.,Yang, Cui-Ping.,...&yxcheng@mail.kib.ac.cn.(2015).Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation.PHYTOCHEMISTRY,114(SI),155-162.
MLA Yan, Yong-Ming,et al."Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation".PHYTOCHEMISTRY 114.SI(2015):155-162.
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