中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation
作者: Yan, Yong-Ming1, 4; Wang, Xin-Long1, 3; Luo, Qi1, 4; Jiang, Li-Ping4, 5; Yang, Cui-Ping5; Hou, Bo1; Zuo, Zhi-Li1; Chen, Yong-Bin5; null(程永现)1, 2
刊名: PHYTOCHEMISTRY
出版日期: 2015-06-01
卷号: 114, 期号:SI, 页码:155-162
关键词: Ganoderma lingzhi ; Ganodermataceae ; Meroterpenoids ; Neural stem cells ; Neurodegenerative diseases
学科分类: Biochemistry & Molecular Biology; Plant Sciences
DOI: 10.1016/j.phytochem.2015.03.013
通讯作者: Chen,YB (reprint author),132 Lanhei Rd,Kunming 650201,Peoples R China. ; ybchen@mail.kiz.ac.cn ; yxcheng@mail.kib.ac.cn
文章类型: Article
英文摘要: Ganoderma lingzhi is a valuable, edible and medicinal fungus that has been widely used for the prevention and treatment of a broad range of diseases. In this study, spirolingzhines A-D, four meroterpenoids with a spiro[benzofuran-2,1'-cyclopentanel motif, lingzhines A-F, six meroterpenoids with diverse ring systems, along with two known compounds were isolated from the fruiting bodies of this fungus. The structures and stereochemistry of these substances were determined by using spectroscopic, X-ray crystallographic and computational methods. Chiral HPLC was used to separate (-)- and (+)-antipodes of seven of ten meroterpenoids, which were isolated from the fungus as racemic mixtures. Several of the metabolites were found to promote proliferation of neural stem cells (NSCs) and, as such, they constitute a class of NSC stimulators. The most potent member of this series, (-)-spirolingzhine A, was shown to affect NSC cell cycle progression using the 5-bromo-2-deoxyuridine (BrdU) incorporation assay. (C) 2015 Elsevier Ltd. All rights reserved.
类目[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]: POLYCYCLIC MEROTERPENOIDS ; NATURAL-PRODUCTS ; DENTATE GYRUS ; LUCIDUM ; COCHLEAR ; NEUROGENESIS ; ACORTATARINS ; POTENT
收录类别: SCI
项目资助者: NSFC-joint Foundation of Yunnan Province [U1202222] ; Open Research Fund of State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, National Natural Science Foundation of China [21472199, 81322030, 31271579] ; "South Drug" Research Collaborative Innovation Organization, Young and Middle Aged Academic Leaders of Kunming, West Light Foundation of the Chinese Academy of Sciences, National Key Basic Research Program of China [2013CB910900]
语种: 英语
WOS记录号: WOS:000356551800014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/21332
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Yan-2015-Metabolites from the mushroom Ganoder.pdf(1019KB)----开放获取View Download

作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China
3.Henan Univ Tradit Chinese Med, Coll Pharm, Zhengzhou 450008, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yan, Yong-Ming]'s Articles
[Wang, Xin-Long]'s Articles
[Luo, Qi]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yan, Yong-Ming]‘s Articles
[Wang, Xin-Long]‘s Articles
[Luo, Qi]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Yan-2015-Metabolites from the mushroom Ganoder.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace