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Selective and facile deacetylation of pentacyclic triterpenoid under methanolic ammonia condition and unambiguous NMR analysis 期刊论文
CHINESE CHEMICAL LETTERS, 2020, 卷号: 31, 期号: 2, 页码: 333-336
作者:  Wang, Han;  Xu, Renyang;  Liang, Shuobin;  Ran, Fuxiang;  Zhang, Lihe;  Zhang, Yongmin;  Zhou, Demin;  Xiao, Sulong
收藏  |  浏览/下载：142/0  |  提交时间：2020/03/24
Pentacyclic triterpenoid  Deacetylation  Methanolic ammonia  Selectivity  Synthesis  
Design and synthesis of novel artemisinin derivatives with potent activities against colorectal cancer in vitro and in vivo 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 182, 页码: 10
作者:  Wang, Liang-Liang;  Kong, Lingmei;  Liu, Hui;  Zhang, Yunqin;  Zhang, Li;  Liu, Xingyong;  Yuan, Feng;  Li, Yan;  Zuo, Zhili
收藏  |  浏览/下载：138/0  |  提交时间：2020/03/02
Artemisinin  Quinazoline  Hybridization  Colorectal cancer  Chemotherapy  
Total Synthesis of (-)-Perezoperezone through an Intermolecular [5+2] Homodimerization of Hydroxy p-Quinone 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 页码: 6
作者:  Long, Yang;  Ding, Yiming;  Wu, Hai;  Qu, Chunlei;  Liang, Hong;  Zhang, Min;  Zhao, Xiaoli;  Long, Xianwen;  Wang, Shu;  Puno, Pema-Tenzin;  Deng, Jun
Adobe PDF(2181Kb)  |  收藏  |  浏览/下载：323/86  |  提交时间：2020/03/26
5+2 cycloaddition  dimerization  natural products  perezoperezone  total synthesis  
Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens 期刊论文
ORGANIC CHEMISTRY FRONTIERS, 2019, 卷号: 6, 期号: 18, 页码: 3274-3281
作者:  Zang, Yi;  Gong, Yi-Hua;  Li, Xu-Wen;  Li, Xiao-Nian;  Liu, Jun-Jun;  Chen, Chun-Mei;  Zhou, Yuan;  Gu, Liang-Hu;  Luo, Zeng-Wei;  Wang, Jian-Ping;  Sun, Wei-Guang;  Zhu, Hu-Cheng;  Zhang, Yong-Hui
Adobe PDF(2538Kb)  |  收藏  |  浏览/下载：210/49  |  提交时间：2019/10/28
Stereocontrolled concise synthesis of (+/-)-halosaline through intramolecular C-H amination 期刊论文
TETRAHEDRON LETTERS, 2019, 卷号: 60, 期号: 27, 页码: 1781-1783
作者:  Meng, Chun-Yan;  Liang, Xiao;  Zhang, Hongbin;  Wei, Kun;  Yang, Yu-Rong
Adobe PDF(482Kb)  |  收藏  |  浏览/下载：190/47  |  提交时间：2019/08/19
C-H amination  Halosaline  Ring-closing metathesis  Total synthesis  
Synthesis and antitumor activity of aza-brazilan derivatives containing imidazolium salt pharmacophores 期刊论文
MEDCHEMCOMM, 2019, 卷号: 10, 期号: 6, 页码: 1027-1036
作者:  Huang, Mingqin;  Duan, Shengzu;  Ma, Xueqiong;  Cai, Bicheng;  Wu, Dongmei;  Li, Yan;  Li, Liang;  Zhang, Hongbin;  Yang, Xiaodong
Adobe PDF(3833Kb)  |  收藏  |  浏览/下载：176/31  |  提交时间：2019/07/29
B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells 期刊论文
ONCOGENE, 2019, 卷号: 38, 期号: 18, 页码: 3371-3386
作者:  Zhou, Hongyu;  Yu, Chunlei;  Kong, Lingmei;  Xu, Xiaoliang;  Yan, Juming;  Li, Yingchao;  An, Tao;  Gong, Liang;  Gong, Yaxiao;  Zhu, Huifang;  Zhang, Hongbin;  Yang, Xiaodong;  Li, Yan
浏览  |  Adobe PDF(5225Kb)  |  收藏  |  浏览/下载：260/33  |  提交时间：2019/06/24
Synthesis and antitumor activity of novel steroidal imidazolium salt derivatives 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 168, 页码: 232-252
作者:  Deng, Guogang;  Zhou, Bei;  Wang, Jing;  Chen, Zhuo;  Gong, Liang;  Gong, Yaxiao;  Wu, Dongmei;  Li, Yan;  Zhang, Hongbin;  Yang, Xiaodong
浏览  |  Adobe PDF(1727Kb)  |  收藏  |  浏览/下载：276/41  |  提交时间：2019/07/29
Diosgenin  Cholesterol  Dehydroepiandrosterone  Imidazolium salt  Antitumor activities  Structure-activity relationships  
Identification of potential AMPK activator by pharmacophore modeling, molecular docking and QSAR study 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019, 卷号: 79, 页码: 165-176
作者:  Li, Yingying;  Peng, Jiale;  Li, Penghua;  Du, Haibo;  Li, Yaping;  Liu, Xingyong;  Zhang, Li;  Wang, Liang-Liang;  Zuo, Zhili
浏览  |  Adobe PDF(7335Kb)  |  收藏  |  浏览/下载：255/29  |  提交时间：2019/07/29
Pharmacophore modeling  Molecular docking  Quantitative structure activity relationship (QSAR)  Molecular dynamics  AMPK  Activator  
Synthesis and structure-activity relationship studies of water-soluble beta-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 166, 页码: 328-338
作者:  Liang, Shuobin;  Li, Man;  Yu, Xiaojuan;  Jin, Hongwei;  Zhang, Yongmin;  Zhang, Lihe;  Zhou, Demin;  Xiao, Sulong
浏览  |  Adobe PDF(1284Kb)  |  收藏  |  浏览/下载：247/33  |  提交时间：2019/04/15
Glycyrrhetinic acid  Cyclodextrin  Click reaction  Influenza virus  Inhibitors