| Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens | |
Zang, Yi1; Gong, Yi-Hua1; Li, Xu-Wen2; Li, Xiao-Nian3; Liu, Jun-Jun1; Chen, Chun-Mei1; Zhou, Yuan1 ; Gu, Liang-Hu1; Luo, Zeng-Wei1; Wang, Jian-Ping1; Sun, Wei-Guang1; Zhu, Hu-Cheng1; Zhang, Yong-Hui1
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| Corresponding Author | Sun, Wei-Guang(weiguang_s@hust.edu.cn) ; Zhu, Hu-Cheng(zhuhucheng@hust.edu.cn) ; Zhang, Yong-Hui(zhangyh@mails.tjmu.edu.cn) |
| 2019-09-21 | |
| Source Publication | ORGANIC CHEMISTRY FRONTIERS
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| ISSN | 2052-4129 |
| Volume | 6Issue:18Pages:3274-3281 |
| Abstract | Three pairs of enantiomers (+/-)-canescones A-C (1-3), along with a pair of stereoisomers canescones D (4) and E (5), aromatic polyketide dimers bearing unprecedented 5/6/6/6/5 heterocyclic chemical architectures with a rare pentacyclic dihydrobenzo[1,4]dioxine core, were isolated from the fungus Penicillium canescens. Structure elucidation unambiguously suggests that 1 and 2 feature a new cyclopentanone ring A rather than a pyrrolidinone or furanone ring present in 3-5. All compounds were assayed for PTP1B inhibitory activity, and their hypothetical biosynthetic pathways were proposed. |
| DOI | 10.1039/c9qo00820a |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000484960000014 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/68627 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Sun, Wei-Guang; Zhu, Hu-Cheng; Zhang, Yong-Hui |
| Affiliation | 1.Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Zang, Yi,Gong, Yi-Hua,Li, Xu-Wen,et al. Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(18):3274-3281. |
| APA | Zang, Yi.,Gong, Yi-Hua.,Li, Xu-Wen.,Li, Xiao-Nian.,Liu, Jun-Jun.,...&Zhang, Yong-Hui.(2019).Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens.ORGANIC CHEMISTRY FRONTIERS,6(18),3274-3281. |
| MLA | Zang, Yi,et al."Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens".ORGANIC CHEMISTRY FRONTIERS 6.18(2019):3274-3281. |
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| zang2019.pdf（2538KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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