Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens
Zang, Yi1; Gong, Yi-Hua1; Li, Xu-Wen2; Li, Xiao-Nian3; Liu, Jun-Jun1; Chen, Chun-Mei1; Zhou, Yuan1; Gu, Liang-Hu1; Luo, Zeng-Wei1; Wang, Jian-Ping1; Sun, Wei-Guang1; Zhu, Hu-Cheng1; Zhang, Yong-Hui1
Corresponding AuthorSun, Wei-Guang(weiguang_s@hust.edu.cn) ; Zhu, Hu-Cheng(zhuhucheng@hust.edu.cn) ; Zhang, Yong-Hui(zhangyh@mails.tjmu.edu.cn)
2019-09-21
Source PublicationORGANIC CHEMISTRY FRONTIERS
ISSN2052-4129
Volume6Issue:18Pages:3274-3281
AbstractThree pairs of enantiomers (+/-)-canescones A-C (1-3), along with a pair of stereoisomers canescones D (4) and E (5), aromatic polyketide dimers bearing unprecedented 5/6/6/6/5 heterocyclic chemical architectures with a rare pentacyclic dihydrobenzo[1,4]dioxine core, were isolated from the fungus Penicillium canescens. Structure elucidation unambiguously suggests that 1 and 2 feature a new cyclopentanone ring A rather than a pyrrolidinone or furanone ring present in 3-5. All compounds were assayed for PTP1B inhibitory activity, and their hypothetical biosynthetic pathways were proposed.
DOI10.1039/c9qo00820a
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000484960000014
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/68627
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorSun, Wei-Guang; Zhu, Hu-Cheng; Zhang, Yong-Hui
Affiliation1.Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zang, Yi,Gong, Yi-Hua,Li, Xu-Wen,et al. Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(18):3274-3281.
APA Zang, Yi.,Gong, Yi-Hua.,Li, Xu-Wen.,Li, Xiao-Nian.,Liu, Jun-Jun.,...&Zhang, Yong-Hui.(2019).Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens.ORGANIC CHEMISTRY FRONTIERS,6(18),3274-3281.
MLA Zang, Yi,et al."Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens".ORGANIC CHEMISTRY FRONTIERS 6.18(2019):3274-3281.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zang, Yi]'s Articles
[Gong, Yi-Hua]'s Articles
[Li, Xu-Wen]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zang, Yi]'s Articles
[Gong, Yi-Hua]'s Articles
[Li, Xu-Wen]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zang, Yi]'s Articles
[Gong, Yi-Hua]'s Articles
[Li, Xu-Wen]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.