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Synthesis of selective 11 beta-HSD1 inhibitors based on dammarane scaffold 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 135, 页码: 324-338
作者:  Shao, Li-Dong;  Bao, Ying;  Shen, Yu;  Su, Jia;  Leng, Ying;  Zhao, Qin-Shi
浏览  |  Adobe PDF(1336Kb)  |  收藏  |  浏览/下载：317/73  |  提交时间：2017/07/31
11 Beta-hsd1 Inhibitor  Hupehenols  Dammarane  Sar  
A biomimetic semisynthesis enables structural elucidation of selaginellin U: a tautomeric cyclic alkynylphenol from Selaginella tamariscina 期刊论文
ROYAL SOCIETY OPEN SCIENCE, 2017, 卷号: 4, 期号: 7, 页码: 170352
作者:  Zhu, Qin-Feng;  Bao, Ying;  Zhang, Zhi-Jun;  Su, Jia;  Shao, Li-Dong;  Zhao, Qin-Shi
浏览  |  Adobe PDF(698Kb)  |  收藏  |  浏览/下载：172/25  |  提交时间：2017/10/23
Biomimetic Semisynthesis  Structural Elucidation  Selaginellins  Alkynylphenol  Selaginella Tamariscina  
Synthesis of hupehenols A, B, and E from protopanaxadiol 期刊论文
RSC ADVANCES, 2016, 卷号: 6, 期号: 42, 页码: 35792-35803
作者:  Shao, Li-Dong;  Xu, Jun;  Li, Xiao-Nian;  Zhang, Zhi-Jun;  Shi, Xin;  Ren, Jian;  He, Juan;  Zhao, Yu;  Leng, Ying;  Xia, Chengfeng;  Zhao, Qin-Shi
浏览  |  Adobe PDF(1402Kb)  |  收藏  |  浏览/下载：232/64  |  提交时间：2016/08/22
Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2015, 卷号: 78, 期号: 2, 页码: 330-334
作者:  Chen, Xuan-Qin;  Shao, Li-Dong;  Pal, Mahesh;  Shen, Yu;  Cheng, Xiao;  Xu, Gang;  Peng, Li-Yan;  Wang, Kou;  Pan, Zheng-Hong;  Li, Ming-Ming;  Leng, Ying;  He, Juan;  Zhao, Qin-Shi;  He,J (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Yunnan,Peoples R China.;  hejuan@mail.kib.ac.cn;  qinshizhao@mail.kib.ac.cn
浏览  |  Adobe PDF(811Kb)  |  收藏  |  浏览/下载：322/93  |  提交时间：2015/06/29
Identification of two novel inhibitors of mTOR signaling pathway based on high content screening 期刊论文
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2013, 卷号: 72, 期号: 4, 页码: 799-808
作者:  Yan, Juming;  Zhou, Hongyu;  Kong, Lingmei;  Zhang, Jing;  Zhao, Qinshi;  Li, Yan
Adobe PDF(1971Kb)  |  收藏  |  浏览/下载：687/105  |  提交时间：2013/11/12
Mtor Signaling  Inhibitor  High Content Screening  Cancer  Apoptosis  
Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11 beta-HSD1 inhibitors: Potential impact in diabetes 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 65, 页码: 403-414
作者:  Deng, Xu;  Shen, Yu;  Yang, Jing;  He, Juan;  Zhao, Yu;  Peng, Li-Yan;  Leng, Ying;  Zhao, Qin-Shi
浏览  |  Adobe PDF(1215Kb)  |  收藏  |  浏览/下载：414/154  |  提交时间：2013/10/16
Ent-kaurene Diterpenoids  Structure-activity Relationship Studies  Selective 11 Beta-hsd1 Inhibitors  Urea Derivatives  Diabetes  
Pseudolaric acid B induces apoptosis via proteasome-mediated Bcl-2 degradation in hormone-refractory prostate cancer DU145 cells 期刊论文
TOXICOLOGY IN VITRO, 2012, 卷号: 26, 期号: 4, 页码: 595-602
作者:  Zhao, Dandan;  Lin, Feng;  Wu, Xingde;  Zhao, Qinshi;  Zhao, Binjiahui;  Lin, Ping;  Zhang, Yanlong;  Yu, Xiaoguang
Adobe PDF(971Kb)  |  收藏  |  浏览/下载：858/174  |  提交时间：2012/06/07
Pseudolaric Acid b  Hormone-refractory Prostate Cancer  Apoptosis  Bcl-2 Degradation  Proteasome  Reactive Oxygen Species  
Isoprenylated Flavonoid and Adipogenesis-Promoting Constituents of Dodonaea viscosa 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2012, 卷号: 75, 期号: 4, 页码: 699-706
作者:  Zhang, Lai-Bin;  Ji, Jun;  Lei, Chun;  Wang, He-Yao;  Zhao, Qin-Shi;  Hou, Ai-Jun
Adobe PDF(393Kb)  |  收藏  |  浏览/下载：501/209  |  提交时间：2012/06/07
Michelia Coriacea  Genetic Diversity  Critically Endangered Plant  Issr Markers  Ssr Markers  Conservation Genetics  Population-genetics  Ssr Markers  Rapd  Issr  Rare  Island  Aflp  Flow  Proteaceae  
New isoprenylated flavonoids and adipogenesis-promoting constituents from Morus notabilis 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 卷号: 21, 期号: 15, 页码: 4441-4446
作者:  Hu, Xiao;  Ji, Jun;  Wang, Meng;  Wu, Jin-Wei;  Zhao, Qin-Shi;  Wang, He-Yao;  Hou, Ai-Jun
Adobe PDF(863Kb)  |  收藏  |  浏览/下载：307/103  |  提交时间：2012/04/10
Morus Notabilis  Isoprenylated Flavonoids  Adipogenesis  
Isoprenylated Flavonoids and Adipogenesis-Promoting Constituents from Morus nigra 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2011, 卷号: 74, 期号: 4, 页码: 816-824
作者:  Hu, Xiao;  Wu, Jin-Wei;  Zhang, Xiao-Dong;  Zhao, Qin-Shi;  Huang, Jian-Ming;  Wang, He-Yao;  Hou, Ai-Jun
Adobe PDF(3054Kb)  |  收藏  |  浏览/下载：328/101  |  提交时间：2012/04/10
Alder-type Adducts  Root Bark  Artocarpus-heterophyllus  Cudrania-tricuspidata  Moraceous Plants  Cells  Antioxidant  Components  Xanthones  Bur