A biomimetic semisynthesis enables structural elucidation of selaginellin U: a tautomeric cyclic alkynylphenol from Selaginella tamariscina
Zhu, Qin-Feng1,2; Bao, Ying1,2; Zhang, Zhi-Jun1,2; Su, Jia1; Shao, Li-Dong1; Zhao, Qin-Shi1
2017-07-01
Source PublicationROYAL SOCIETY OPEN SCIENCE
ISSN2054-5703
Volume4Issue:7Pages:170352
AbstractTwo new lactone-containing selaginellins T and U (1 and 2) together with eleven known selaginellin derivatives (3 and 7-16) were isolated from the whole plant of Selaginella tamariscina. The structure of tautomeric selaginellin U along with its biogenetic pathway was confirmed and proposed by a cross-validation of the semisynthesis of compound 4 from selaginellin (3) and derivation from 2 to 4. Additionally, compounds 3, 13 and 16 exhibited good inhibitory activities against beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) with IC50 values of 81.17, 51.13 and 48.89 mu M, respectively.
KeywordBiomimetic Semisynthesis Structural Elucidation Selaginellins Alkynylphenol Selaginella Tamariscina
Subject AreaMultidisciplinary Sciences
DOI10.1098/rsos.170352
Indexed BySCI
Language英语
WOS IDWOS:000406670000033
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/54948
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Qin-Feng,Bao, Ying,Zhang, Zhi-Jun,et al. A biomimetic semisynthesis enables structural elucidation of selaginellin U: a tautomeric cyclic alkynylphenol from Selaginella tamariscina[J]. ROYAL SOCIETY OPEN SCIENCE,2017,4(7):170352.
APA Zhu, Qin-Feng,Bao, Ying,Zhang, Zhi-Jun,Su, Jia,Shao, Li-Dong,&Zhao, Qin-Shi.(2017).A biomimetic semisynthesis enables structural elucidation of selaginellin U: a tautomeric cyclic alkynylphenol from Selaginella tamariscina.ROYAL SOCIETY OPEN SCIENCE,4(7),170352.
MLA Zhu, Qin-Feng,et al."A biomimetic semisynthesis enables structural elucidation of selaginellin U: a tautomeric cyclic alkynylphenol from Selaginella tamariscina".ROYAL SOCIETY OPEN SCIENCE 4.7(2017):170352.
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