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Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning 期刊论文
CELL REPORTS, 2019, 卷号: 28, 期号: 2, 页码: 541-+
作者:  Ma, Pengcheng;  Song, Ning-Ning;  Li, Yongxin;  Zhang, Qiong;  Zhang, Lei;  Zhang, Longlong;  Kong, Qinghua;  Ma, Li;  Yang, Xiangcai;  Ren, Biyu;  Li, Chaocui;  Zhao, Xudong;  Li, Yan;  Xu, Ying;  Gao, Xiang;  Ding, Yu-Qiang;  Mao, Bingyu
浏览  |  Adobe PDF(5547Kb)  |  收藏  |  浏览/下载：312/59  |  提交时间：2019/08/19
Design, Synthesis, and Biological Evaluation of Novel Biotinylated Podophyllotoxin Derivatives as Potential Antitumor Agents 期刊论文
FRONTIERS IN CHEMISTRY, 2019, 卷号: 7, 页码: 14
作者:  Zi, Cheng-Ting;  Gao, Yin-Sheng;  Yang, Liu;  Feng, Shu-Yun;  Huang, Yue;  Sun, Li;  Jin, Yi;  Xu, Feng-Qing;  Dong, Fa-Wu;  Li, Yan;  Ding, Zhong-Tao;  Zhou, Jun;  Jiang, Zi-Hua;  Yuan, Sheng-Tao;  Hu, Jiang-Miao
浏览  |  Adobe PDF(1387Kb)  |  收藏  |  浏览/下载：302/72  |  提交时间：2019/07/29
podophyllotoxin derivatives  biotin  anticancer activity  synthesis  apoptosis  
B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells 期刊论文
ONCOGENE, 2019, 卷号: 38, 期号: 18, 页码: 3371-3386
作者:  Zhou, Hongyu;  Yu, Chunlei;  Kong, Lingmei;  Xu, Xiaoliang;  Yan, Juming;  Li, Yingchao;  An, Tao;  Gong, Liang;  Gong, Yaxiao;  Zhu, Huifang;  Zhang, Hongbin;  Yang, Xiaodong;  Li, Yan
浏览  |  Adobe PDF(5225Kb)  |  收藏  |  浏览/下载：279/37  |  提交时间：2019/06/24
Physalis peruviana-Derived 4 beta-Hydroxywithanolide E, a Novel Antagonist of Wnt Signaling, Inhibits Colorectal Cancer In Vitro and In Vivo 期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 6, 页码: 13
作者:  Ye, Zhen-Nan;  Yuan, Feng;  Liu, Jie-Qing;  Peng, Xing-Rong;  An, Tao;  Li, Xue;  Kong, Ling-Mei;  Qiu, Ming-Hua;  Li, Yan
浏览  |  Adobe PDF(3189Kb)  |  收藏  |  浏览/下载：212/40  |  提交时间：2019/07/29
4 beta HWE  Wnt signaling pathway  beta-catenin  colorectal cancer  
Design, Synthesis, and Biological Activities of Vibsanin B Derivatives: A New Class of HSP90 C-Terminal Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 21, 页码: 9053-9066
作者:  Shao, Li-Dong;  Su, Jia;  Ye, Baixin;  Liu, Jiang-Xin;  Zuo, Zhi-Li;  Li, Yan;  Wang, Yue-Ying;  Xia, Chengfeng;  Zhao, Qin-Shi
浏览  |  Adobe PDF(5724Kb)  |  收藏  |  浏览/下载：411/46  |  提交时间：2017/12/18
N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells 期刊论文
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2016, 卷号: 35
作者:  Wang, Min;  Zhou, Ankun;  An, Tao;  Kong, Lingmei;  Yu, Chunlei;  Liu, Jianmei;  Xia, Chengfeng;  Zhou, Hongyu;  Li, Yan
浏览  |  Adobe PDF(1734Kb)  |  收藏  |  浏览/下载：282/61  |  提交时间：2016/06/27
N-hydroxyphthalimide  Mtor  Inhibitor  Cancer  Mitochondrial Apoptosis  
Design, Synthesis, and Cytotoxicity of Perbutyrylated Glycosides of 4 beta-Triazolopodophyllotoxin Derivatives 期刊论文
MOLECULES, 2015, 卷号: 20, 期号: 2, 页码: 3255-3280
作者:  Zi, Cheng-Ting;  Liu, Zhen-Hua;  Li, Gen-Tao;  Li, Yan;  Zhou, Jun;  Ding, Zhong-Tao;  Hu, Jiang-Miao;  Jiang, Zi-Hua;  Ding,ZT (reprint author),Yunnan Univ,Key Lab Med Chem Nat Resource,Minist Educ,Sch Chem Sci & Technol,Kunming 650091,Peoples R China.;  zict@sina.cn;  liuzhenhua@mail.kib.ac.cn;  ligentao@mail.kib.ac.cn;  liyanb@mail.kib.ac.cn;  jzhou@mail.kib.ac.cn;  ztding@ynu.edu.cn;  hujiangmiao@mail.kib.ac.cn;  zjiang@lakeheadu.ca
浏览  |  Adobe PDF(910Kb)  |  收藏  |  浏览/下载：288/65  |  提交时间：2015/06/29
Synthesis and Anticancer Activity of Glucosylated Podophyllotoxin Derivatives Linked via 4 beta-Triazole Rings 期刊论文
MOLECULES, 2013, 卷号: 18, 期号: 11, 页码: 13992-14012
作者:  Zi, Cheng-Ting;  Xu, Feng-Qing;  Li, Gen-Tao;  Li, Yan;  Ding, Zhong-Tao;  Zhou, Jun;  Jiang, Zi-Hua;  Hu, Jiang-Miao
浏览  |  Adobe PDF(404Kb)  |  收藏  |  浏览/下载：217/59  |  提交时间：2015/05/13
Podophyllotoxin  4 Beta-triazole Ring  Click Chemistry  Anticancer Activity  
Trichothecin Induces Cell Death in NF-kappa B Constitutively Activated Human Cancer Cells via Inhibition of IKK beta Phosphorylation 期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 8, 页码: e71333
作者:  Su, Jia;  Zhao, Peiji;  Kong, Lingmei;  Li, Xingyao;  Yan, Juming;  Zeng, Ying;  Li, Yan
浏览  |  Adobe PDF(1124Kb)  |  收藏  |  浏览/下载：346/69  |  提交时间：2013/11/12
Colitis-associated Cancer  Multiple-myeloma Cells  P65 Phosphorylation  Endophytic Fungus  Kinase-activity  Tumor-growth  In-vitro  Pathway  Apoptosis  Inflammation  
Henryin, an ent-kaurane Diterpenoid, Inhibits Wnt Signaling through Interference with beta-Catenin/TCF4 Interaction in Colorectal Cancer Cells 期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 7, 页码: e68525
作者:  Li, Xingyao;  Pu, Jianxin;  Jiang, Shiyou;  Su, Jia;  Kong, Lingmei;  Mao, Bingyu;  Sun, Handong;  Li, Yan
浏览  |  Adobe PDF(1775Kb)  |  收藏  |  浏览/下载：597/114  |  提交时间：2013/10/16
Beta-catenin  Colon-cancer  Response Element  Activation  Expression  Pathway  Complex  Growth  Apc  Antagonists