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Sesquiterpenoids from Alpinia oxyphylla with GLP-1 Stimulative Effects through Ca2+/CaMKII and PKA Pathways and Multiple-Enzyme Inhibition 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2023, 卷号: 71, 期号: 43, 页码: 16148-16159
作者:  Cui,Can;  Wu,Sheng-Li;  Chen,Ji-Jun;  Gongpan,Pianchou;  Guan,Min;  Geng,Chang-An
浏览  |  Adobe PDF(2550Kb)  |  收藏  |  浏览/下载：61/10  |  提交时间：2024/07/10
Alpinia oxyphylla  sesquiterpenoids  GLP-1 stimulation  Ca2+/CaMKII and PKA pathways  alpha-glucosidase and PTP1B inhibitory activity  
Four new phenolic compounds from the fruits of Alpinia galanga 期刊论文
PHYTOCHEMISTRY LETTERS, 2023, 卷号: 55, 页码: 75-79
作者:  Liu,Pei;  Wu,Sheng-Li;  Wang,Tian;  Zhang,Xue-Mei;  Geng,Chang-An
浏览  |  Adobe PDF(557Kb)  |  收藏  |  浏览/下载：37/8  |  提交时间：2024/07/22
Alpinia galanga  Phenolic compounds  PTP1B inhibitory activity  ?-glycosidase inhibitory activity  GLP-1 secretion  
Synthesis and biological evaluation of (20S,24R)-epoxy-dammarane-3 beta,12 beta,25-triol derivatives as alpha-glucosidase and PTP1B inhibitors 期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2022, 卷号: 31, 期号: 2, 页码: 350-367
作者:  Yang, Xiao-Tong;  Li, Tian-Ze;  Geng, Chang-An;  Liu, Pei;  Chen, Ji-Jun
浏览  |  Adobe PDF(1348Kb)  |  收藏  |  浏览/下载：74/15  |  提交时间：2024/04/30
(20S,24R)-epoxy-dammarane-3 beta,12 beta,25-triol  alpha-glucosidase inhibitors  PTP1B inhibitors  Enzyme kinetics  TYROSINE-PHOSPHATASE 1B  DIABETES-MELLITUS  EPIDEMIOLOGY  
Triterpenoids from Uncaria rhynchophylla and Their PTP1B Inhibitory Activity 期刊论文
PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY, 2022, 卷号: 91, 期号: 8, 页码: 1809-1816
作者:  Luo, Shuaibin;  Zhang, Xuemei;  He, Kang;  Zou, Juan;  Geng, Chang-An
浏览  |  Adobe PDF(486Kb)  |  收藏  |  浏览/下载：116/14  |  提交时间：2024/04/30
Uncaria rhynchophylla  triterpenoids  antidiabetic effects  PTP1B inhibitors  ALKALOIDS  
Chemical profiling and antidiabetic potency of Paeonia delavayi: Comparison between different parts and constituents 期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 198, 页码: 113998
作者:  Huang,Qian;  Chen,Ji-Jun;  Pan,Yang;  He,Xiao-Feng;  Wang,Yuan;  Zhang,Xue-Mei;  Geng,Chang-An
浏览  |  Adobe PDF(2388Kb)  |  收藏  |  浏览/下载：117/26  |  提交时间：2022/04/02
Paeonia delavayi  Chemical comparison  LCMS analyses  Antidiabetic effects  PTP1B/TCPTP selective inhibitors  LIQUID-CHROMATOGRAPHY  MULTIPLE CONSTITUENTS  RAPID IDENTIFICATION  GLYCOSIDES  ROOT  DERIVATIVES  TARGETS  CAPSULE  L.  
The antidiabetic potency of Amomum tsao-ko and its active flavanols, as PTP1B selective and alpha-glucosidase dual inhibitors 期刊论文
INDUSTRIAL CROPS AND PRODUCTS, 2021, 卷号: 160, 页码: 112908
作者:  He,Xiao-Feng;  Chen,Ji-Jun;  Huang,Xiao-Yan;  Hu,Jing;  Zhang,Xu-Ke;  Guo,Yuan-Qiang;  Zhang,Xue-Mei;  Geng,Chang-An
浏览  |  Adobe PDF(5184Kb)  |  收藏  |  浏览/下载：141/36  |  提交时间：2022/04/02
Amomum tsao-ko  Amomutsaokins A-H  Flavanol-menthane conjugates  PTP1B selective inhibitors  alpha-Glucosidase inhibitors  ANTIOXIDANT ACTIVITY  ESSENTIAL OIL  CONSTITUENTS  TANNINS  CREVOST  ACID  
Diarylheptanoid-chalcone hybrids with PTP1B and alpha-glucosidase dual inhibition from Alpinia katsumadai 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 108, 页码: 104683
作者:  He,Xiao-Feng;  Chen,Ji-Jun;  Li,Tian-Ze;  Hu,Jing;  Zhang,Xue-Mei;  Geng,Chang-An
浏览  |  Adobe PDF(2223Kb)  |  收藏  |  浏览/下载：196/76  |  提交时间：2022/04/02
Alpinia katsumadai  Katsumadainols A(1)-A(16)  PTP1B/TCPTP selective inhibitors  alpha-glucosidase inhibitors  Antidiabetic effects  THEORETICAL CALCULATION  ABSOLUTE-CONFIGURATION  SEEDS  BLEPHAROCALYXINS  ADDUCT  MOIETY  
An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 166, 页码: 400-416
作者:  Li, Chun-Huan;  Zhang, Jia-Yao;  Zhang, Xiu-Yun;  Li, Sheng-Hong;  Gao, Jin-Ming
浏览  |  Adobe PDF(2414Kb)  |  收藏  |  浏览/下载：310/56  |  提交时间：2019/04/15
Grayanane diterpenoids  Ericaceae  Bioactivities  Analgesic activity  Anti-inflammatory activity  PTP1B inhibitory activity  Structure-activity relationship  
New phloroglucinol derivatives with protein tyrosine phosphatase 1B (PTP1B) inhibitory activities from Syzygium austroyunnanense 期刊论文
FITOTERAPIA, 2018, 卷号: 131, 页码: 141-145
作者:  Xu, Shao-Hua;  Xu, Wen;  Wang, Li;  Hu, Yi-Kao;  Liu, Jin-Ping;  Zhao, Yan;  Li, Meng-Jia;  Li, Feng;  Huang, Sheng-Xiong;  Zhao, Yong
收藏  |  浏览/下载：191/0  |  提交时间：2019/03/18
Syzygium austroyunnanense  Myrtaceae  Phloroglucinol derivatives  Structure elucidation  PTP 1B inhibitory activities  
Two new gamma-lactones from the cultures of basidiomycete Lenzites betulinus 期刊论文
PHYTOCHEMISTRY LETTERS, 2017, 卷号: 20, 页码: 9-12
作者:  Wen, Chun-Nan;  Chen, He-Ping;  Zhao, Zhen-Zhu;  Hu, Dong-Bao;  Li, Zheng-Hui;  Feng, Tao;  Liu, Ji-Kai
浏览  |  Adobe PDF(736Kb)  |  收藏  |  浏览/下载：243/76  |  提交时间：2017/09/20
Lenzites Betulinus  Betulactone a  Ptp1b