An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years
Li, Chun-Huan1; Zhang, Jia-Yao1; Zhang, Xiu-Yun1; Li, Sheng-Hong2; Gao, Jin-Ming1
2019-03-15
Source PublicationEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN0223-5234
Volume166Pages:400-416
AbstractGrayanane diterpenoids, possessing a unique 5/7/6/5 tetracyclic system, exist exclusively in plants of the Ericaceae family. Owing to their various skeletons, complex structures, and diverse bioactivities, grayanoids have been the topic of research in many phytochemical and pharmacological laboratories, offering opportunities for the development of new drugs with analgesic, anti-inflammatory, and protein tyrosine phosphatase 1B (PTP1B) properties. Recently, a number of new grayanane diterpenoids with unprecedented carbon skeletons have been obtained from plants of the Ericaceae family, and they exhibit diverse biological properties, such as agalgesic, antinociceptive, anticancer, antiviral, antifeedant, insecticidal, toxicity, and PTP1B. In this review, 162 new grayanoids with 14 carbon skeletons from the Ericaceae family over the past seven years (2012 October 2018) are discussed, including their occurrence and distribution, skeleton types, structural features, biological activities, and structure-activity relationships (SARs). Also, strategies for the structural elucidation are summarized to provide useful information for medicinal chemists in developing potent anticancer, antiviral, analgesic, anti-inflammatory, and novel PTP1B agents. (C) 2019 Elsevier Masson SAS. All rights reserved.
KeywordGrayanane diterpenoids Ericaceae Bioactivities Analgesic activity Anti-inflammatory activity PTP1B inhibitory activity Structure-activity relationship
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/65190
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLi, Sheng-Hong; Gao, Jin-Ming
Affiliation1.Northwest A&F Univ, Shaanxi Key Lab Nat Prod & Chem Biol, Coll Chem & Pharm, Yangling 712100, Shaanxi, Peoples R China
2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Li, Chun-Huan,Zhang, Jia-Yao,Zhang, Xiu-Yun,et al. An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2019,166:400-416.
APA Li, Chun-Huan,Zhang, Jia-Yao,Zhang, Xiu-Yun,Li, Sheng-Hong,&Gao, Jin-Ming.(2019).An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,166,400-416.
MLA Li, Chun-Huan,et al."An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 166(2019):400-416.
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